个人简介
Dr. Wang is Associate professor of Biostatistics at Yale School of Public Health and affiliate member of the Program on Computational Biology and Bioinformatics. Her research focuses on the development of statistical and computational methods to address problems in genetics, in particular, the identification of genes contributing to human complex diseases, such as alcohol use disorder and cancer. She has developed statistical methods to address both dependent and partially-observed data and has applied these methods to problems in association analysis of complex traits in related individuals and longitudinal measured phenotypes. Current studies include using next-generation sequencing and exome chip data to detect rare variants and studying epigenomic variation.
PhD University of Chicago (2009)
MS University of Florida (2004)
近期论文
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A comparison of association methods correcting for population stratification in case-control studies.
Wu, C., DeWan, A., Hoh, J., and Wang, Z., (2011) A comparison of association methods correcting for population stratification in case-control studies. Annals of Human Genetics, 75:418-427.
Direct assessment of multiple testing correction in case-control association studies with related individuals.
Wang, Z., (2011) Direct assessment of multiple testing correction in case-control association studies with related individuals. Genetic Epidemiology, 35:70-79.
An incomplete-data quasi-likelihood approach to haplotype-based genetic association studies on related individuals.
Wang, Z., and McPeek, M.S., (2009) An incomplete-data quasi-likelihood approach to haplotype-based genetic association studies on related individuals. Journal of the American Statistical Association, 104:1251-1260.
ATRIUM: Testing untyped SNPs in case-control association studies with related individuals.
Wang, Z., and McPeek, M.S., (2009) ATRIUM: Testing untyped SNPs in case-control association studies with related individuals. American Journal of Human Genetics, 85:667-678.
Joint functional mapping of quantitative trait loci for HIV-1 and CD4+ dynamics. Wang, Z., Li, Y., Li, Q., and Wu, R., (2009) Joint functional mapping of quantitative trait loci for HIV-1 and CD4+ dynamics. The International Journal of Biostatistics, Vol. 5: Iss. 1, Article 9.
Lu L, Bai Y, Wang Z: Elevated T cell activation score is associated with improved survival of breast cancer. Breast Cancer Res Treat. 2017 May 9; 2017 May 9. PMID: 28488141
Salazar MC, Rosen JE, Wang Z, Arnold BN, Thomas DC, Herbst RS, Kim AW, Detterbeck FC, Blasberg JD, Boffa DJ: Association of Delayed Adjuvant Chemotherapy With Survival After Lung Cancer Surgery. JAMA Oncol. 2017 May 1. PMID: 28056112
Fragoso CA, Moreno M, Wang Z, Heffelfinger C, Arbelaez LJ, Aguirre JA, Franco N, Romero LE, Labadie K, Zhao H, Dellaporta SL, Lorieux M: Genetic Architecture of a Rice Nested Association Mapping Population. G3 (Bethesda). 2017 Apr 26; 2017 Apr 26. PMID: 28450374
Wang Z: Integrating evolutionary game theory into epigenetic study of embryonic development: Comment on "Epigenetic game theory: How to compute the epigenetic control of maternal-to-zygotic transition" by Qian Wang et al. Phys Life Rev. 2017 Mar; 2017 Jan 12. PMID: 28094147
Jawitz OK, Wang Z, Boffa DJ, Detterbeck FC, Blasberg JD, Kim AW: The differential impact of preoperative comorbidity on perioperative outcomes following thoracoscopic and open lobectomies. Eur J Cardiothorac Surg. 2017 Jan; 2016 Jul 25. PMID: 27458143
Wang Z, Xu K, Zhang X, Wu X, Wang Z: Longitudinal SNP-set association analysis of quantitative phenotypes. Genet Epidemiol. 2017 Jan; 2016 Nov 9. PMID: 27859628
Xu K, Zhang X, Wang Z, Hu Y, Sinha R: Epigenome-wide association analysis revealed that SOCS3 methylation influences the effect of cumulative stress on obesity. Biol Psychol. 2016 Nov 5; 2016 Nov 5. PMID: 27826092
Han L, Cai Q, Tian D, Kong DK, Gou X, Chen Z, Strittmatter SM, Wang Z, Sheth KN, Zhou J: Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles. Nanomedicine. 2016 Oct; 2016 Mar 30. PMID: 27039220
Zhang X, Justice AC, Hu Y, Wang Z, Zhao H, Wang G, Johnson EO, Emu B, Sutton RE, Krystal JH, Xu K: Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals. Epigenetics. 2016 Aug 12; 2016 Aug 12. PMID: 27672717
DeLuzio MR, Keshava HB, Wang Z, Boffa DJ, Detterbeck FC, Kim AW: A model for predicting prolonged length of stay in patients undergoing anatomical lung resection: a National Surgical Quality Improvement Program (NSQIP) database study. Interact Cardiovasc Thorac Surg. 2016 Aug; 2016 Apr 12. PMID: 27073262
Rosen JE, Salazar MC, Wang Z, Yu JB, Decker RH, Kim AW, Detterbeck FC, Boffa DJ: Lobectomy versus stereotactic body radiotherapy in healthy patients with stage I lung cancer. J Thorac Cardiovasc Surg. 2016 Jul; 2016 Apr 7. PMID: 27131846
Jawitz OK, Boffa DJ, Detterbeck FC, Wang Z, Kim AW: Estimating the Annual Incremental Cost of Several Complications Following Pulmonary Lobectomy. Semin Thorac Cardiovasc Surg. 2016 Summer; 2016 Jun 14. PMID: 28043473
Jean RA, DeLuzio MR, Kraev AI, Wang G, Boffa DJ, Detterbeck FC, Wang Z, Kim AW: Analyzing Risk Factors for Morbidity and Mortality after Lung Resection for Lung Cancer Using the NSQIP Database. J Am Coll Surg. 2016 Jun; 2016 Mar 8. PMID: 27118714
Liu J, Hancock JG, Moreno AC, Wang Z, Boffa DJ, Detterbeck FC, Kim AW: Evaluating the fate of patients who undergo resections of very large, node-negative lung cancers using the National Cancer DataBase. Eur J Cardiothorac Surg. 2016 Feb; 2015 Apr 18. PMID: 25890936
DeLuzio MR, Moores C, Dhamija A, Wang Z, Cha C, Boffa DJ, Detterbeck FC, Kim AW: Resection of oligometastatic lung cancer to the pancreas may yield a survival benefit in select patients--a systematic review. Pancreatology. 2015 Sep-Oct; 2015 Apr 3. PMID: 25900320
Assi R, Wong DJ, Boffa DJ, Detterbeck FC, Wang Z, Chupp GL, Kim AW: Hospital readmission after pulmonary lobectomy is not affected by surgical approach. Ann Thorac Surg. 2015 Feb; 2014 Dec 12. PMID: 25497070
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