Wajapeyee, Narendra - Yale University - Biological & Biomedical Sciences

个人简介

Cancer is a complex disease and typically involves multiple gene-specific and global genetic and epigenetic changes in human genome. The major classes of genes that have been causally linked to the process of tumorigenesis is tumor suppressors, which act as “brakes”, and oncogenes, which function as “accelerators” and typically promote cancer. Recently, non-coding RNAs such as miRNAs and long non-coding RNAs are also linked to cancer, wherein they can either promote or inhibit cancer cell growth. The focus of our lab is to understand the mechanisms of genetic and epigenetic regulation of cancer initiation and progression and translating this understanding for early detection and treatment of human cancers. We use melanoma, pancreatic cancer, lung cancer, hepatocellular carcinoma and hematological malignancies as model systems to study mechanism of tumor initiation and progression. PhD Indian Institute of Science, India (2005)

研究领域

Genetics; Carcinoma, Hepatocellular; Lung Neoplasms; Melanoma; Pancreatic Neoplasms; Pathology; Disease Progression; Carcinogenesis; Phenomena and Processes

近期论文

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Interferon Alpha-Inducible Protein 6 regulates NRASQ61K-induced melanomagenesis and growth. Romi Gupta, Matteo Forloni, Malik Bisseier, Shaillay Kumar Dogra, Qiahong Yang, Narendra Wajapeyee. Elife. 2016 Sep 8;5. pii: e16432. doi: 10.7554/eLife.16432. MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels Arvindhan Nagarajan*, Max C. Petersen*, Ali R. Nasiri, Gina Butrico, Annie Fung, Hai-Bin Ruan, Romy Kursawe, Sonia Caprio, Jacques Thibodeau, Marie-Claude Bourgeois-Daigneault, Lisha Sun, Guangping Gao, Sanjay Bhanot, Michael J. Jurczak, Michael R. Green, Gerald I. Shulman#, Narendra Wajapeyee#. Nature Communications, 2016 Aug 31;7:12639. doi: 10.1038/ncomms12639. Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells Forloni M, Gupta R, Nagarajan A, Sun LS, Dong Y, Pirazzoli V, Toki M, Wurtz A, Melnick MA, Kobayashi S, Homer RJ, Rimm DL, Gettinger SJ, Politi K, Dogra SK, Wajapeyee N. Cell Reports. 2016 Jul 12;16(2):457-71. doi: 10.1016/j.celrep.2016.05.087. Epub 2016 Jun 23. Oncogenic BRAF induces Senesences through an Autocrine/Paracrine pathway by the Secreted Protein IGFBP7. Narendra Wajapeyee, Ryan Serra, XiaChun Zhu, Meera Mahalingam and Michael R Green. Cell , 8th Feb 2008. 132; 363- Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. Wajapeyee N#, Malonia SK, Palakurthy RK, Green MR#. Genes & Development. 2013 Oct 15;27(20):2221-6. doi: 10.1101/gad.227413.113. Epub 2013 Oct 8. Joint-corresponding authors Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Romi Gupta, Yuying Dong, Peter D. Solomon, Hiromi I Wettersten, Christopher Cheng, Jin-Na Min, Jeremy D. Henson, Shaillay K. Dogra, Sung H. Hwang, Bruce D. Hammock, Lihua J. Zhu, Roger R. Reddel, W. Mark Saltzman, Robert H. Weiss, Sandy Chang, Michael R. Green and Narendra Wajapeyee. Proc Natl Acad Sci USA, July 29th, 2014: 111(30):E3062-71. miR-146a promotes the initiation and progression of melanoma by activating Notch signaling. Matteo Forloni, Shaillay Kumar Dogra, Yuying Dong, Darryl Conte Jr, Jianhong Ou, Lihua Julie Zhu, April Deng, Meera Mahalingam, Michael R. Green and Narendra Wajapeyee. Elife, Feb 18; 3:e01460.2014 F-Box Protein FBXO31 Mediates Cyclin D1 Degradation to Induce G1 Arrest Following DNA Damage. Manas K. Santra#, Narendra Wajapeyee# and Michael R. Green. Nature, 4th June, 2009.459: 722-5.# Co-first authors Gupta R, Wajapeyee N: Transcriptional Analysis-Based Integrative Genomics Approach to Identify Tumor-Promoting Metabolic Genes. Methods Mol Biol. 2017. PMID: 27832547 Forloni M, Ho T, Sun L, Wajapeyee N: Large-Scale RNA Interference Screening to Identify Transcriptional Regulators of a Tumor Suppressor Gene. Methods Mol Biol. 2017. PMID: 27832546 Lizardi PM, Yan Q, Wajapeyee N: DNA Bisulfite Sequencing for Single-Nucleotide-Resolution DNA Methylation Detection. Cold Spring Harb Protoc. 2016 Nov 16; 2016 Nov 16. PMID: 27852843 Lizardi PM, Yan Q, Wajapeyee N: High-Throughput Deep Sequencing for Mapping Mammalian DNA Methylation. Cold Spring Harb Protoc. 2016 Nov 16; 2016 Nov 16. PMID: 27852842 Lizardi PM, Yan Q, Wajapeyee N: Illumina Sequencing of Bisulfite-Converted DNA Libraries. Cold Spring Harb Protoc. 2016 Nov 16; 2016 Nov 16. PMID: 27852841 Lizardi PM, Yan Q, Wajapeyee N: Methyl-Cytosine-Based Immunoprecipitation for DNA Methylation Analysis. Cold Spring Harb Protoc. 2016 Nov 16; 2016 Nov 16. PMID: 27852840 Lizardi PM, Yan Q, Wajapeyee N: Analysis of DNA Methylation in Mammalian Cells. Cold Spring Harb Protoc. 2016 Nov 16; 2016 Nov 16. PMID: 27852839 Lizardi PM, Yan Q, Wajapeyee N: Methylation-Specific Polymerase Chain Reaction (PCR) for Gene-Specific DNA Methylation Detection. Cold Spring Harb Protoc. 2016 Nov 16; 2016 Nov 16. PMID: 27852838 Gupta R, Forloni M, Bisserier M, Dogra SK, Yang Q, Wajapeyee N: Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth. Elife. 2016 Sep 8; 2016 Sep 8. PMID: 27608486