Wagner, Gunter Paul - Yale University - Biological & Biomedical Sciences

个人简介

Günter P. Wagner is an evolutionary geneticist with training in biochemcial engineering, zoology and mathematics from the University of Vienna, Austria. He spent six postdoctoral years at the Max Planck Institutes for Biophysical Chemistry (Goettingen, Germany) and for Developmental Biology (Tübingen, Germany). His academic career started at the University of Vienna and in 1991 he received a call to assume a full professorship at the Biology Department at Yale. From 1996 to 2001 he was Chair of the Department of Ecology and Evolutionary Biology at Yale, and in 2010 his lab moved to the Systems Biology Institute at Yale's West Campus. Dr. Wagner's research interest is the evolution of gene regulation as it pertains to the origin of evolutionary novelties. In particular the lab is focusing on the evolution of the endometrial stromal cells in the context of the evolutionary origin of pregnancy. Another focus of my lab is the developmental basis of character identity, as for instance in the case of digit identity of birds. In 1992 Dr. Wagner received the MacArthur Fellowship for my research on the developmental basis of homology and in 1997 he was elected both to become corresponding member of the Austrian Academy of Sciences, and Fellow of the American Association for the Advancement of Science. In 2010 Dr, Wagner was elected to the American Academy of Arts and Sciences. PhD University of Vienna, Zoology (1979) Postdoc Max-Planck-Institute for Developmental Biology Postdoc University of Goettingen, Goettingen, Germany Postdoc Max Planck Institute for Biophysical Chemistry

研究领域

Mammals; Organisms

近期论文

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The developmental genetics of homology. Wagner, G.P. (2007). The developmental genetics of homology. Nat. Rev. Genet. (6):473-9. Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals. Lynch, V. J., A. Tanzer, Y. Wang, F. C. Leung, B. Gellersen, and G. P. Wagner 2008 Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals. Proc. Natl. Acad. Sci. USA, 105:14928-14933. Pleiotropic scaling of gene effects an the “cost of complexity.” Wagner, G. P., J. P. Kenny-Hunt, M. Pavlicev, J. R. Peck, D. Waxman and J. Cheverund 2008. Pleiotropic scaling of gene effects an the “cost of complexity.” Nature, 452: 470-472. Measuring transcription factor binding site turnover: a maximum likelihood approach using phylogenies. Otto, W., P. F. Stader, F. López-Gialdéz, J. P. Townsend, V. J. Lynch, and G. P. Wagner 2009. Measuring transcription factor binding site turnover: a maximum likelihood approach using phylogenies. Genome Biology and Evolution, 1:85-98. Cartilage formation and digit identity in bird evolution and Cyclopamine-treated wings. Vargas, A. O. and G. P. Wagner 2009. Cartilage formation and digit identity in bird evolution and Cyclopamine-treated wings. Evolution and Development, 11:163-169. The Gene regulatory logic of transcription factor evolution. Trends in Ecology and Evolution Wagner, G. P., and V. J. Lynch 2008 The Gene regulatory logic of transcription factor evolution. Trends in Ecology and Evolution, 23: 377-385. The road to modularity. Wagner, G. P., M. Pavlicev and J. Cheverud 2007. The road to modularity. Nature Reviews Genetics, 8:921-931. A stochastic model for transcription factor binding site abundance. Wagner, GP, W. Otto, V. Lynch, and PF Stadler 2007. A stochastic model for transcription factor binding site abundance. J. theor, Biol., 247:544-553. Evidence for the reversibility of digit loss: a phylogenetic study of limb evolution in the genus Bachia (Gymnophthalmidae: Squamata). Kohlsdorf, T and G. P. Wagner 2006 Evidence for the reversibility of digit loss: a phylogenetic study of limb evolution in the genus Bachia (Gymnophthalmidae: Squamata). Evolution 60: 1896-1912. The “fish specific” Hox cluster duplication is coincidental with the origin of teleosts. Crow K. D., Stadler PF, Lynch V, Amemiya C, Wagner GP (2006) The “fish specific” Hox cluster duplication is coincidental with the origin of teleosts. Mol Biol. & Evol, 23:121-136. 1,2,3 = 2,3,4: a solution to the problem of the homology of the digits in the avian hand Wagner, G. P., and J. Gauthier 1999. 1,2,3 = 2,3,4: a solution to the problem of the homology of the digits in the avian hand. Proc. Natl. Acad. Sci. USA, 96, 5111-5116.