van Wolfswinkel, Josien - Yale University - Biological & Biomedical Sciences

个人简介

Josien van Wolfswinkel received her M.Sc. in Cell Biology from Utrecht University, Netherlands. For her graduate research she worked in the laboratories of Ronald Plasterk, Albert Heck, and Rene Ketting at Utrecht University and the Hubrecht Institute for Developmental Biology to study the molecular mechanism of RNA interference in the nematode C. elegans. She did her postdoctoral research in the lab of Peter Reddien at the Whitehead Institute for Biomedical Research / MIT, working on the RNA biology of stem cells using the flatworm Schmidtea mediterranea as a model system. She now continues this work in her own lab in the Department of Molecular Cellular and Developmental Biology. PhD Utrecht University, Hubrecht Institute, Chemistry (2009) MSc Utrecht University, Molecular Cell Biology (2002) Postdoctoral Fellow Whitehead Institute / MIT

研究领域

Germ Cells; Molecular Biology; Regeneration; Developmental Biology; Cell Lineage; Genomics; Regulatory Sequences, Ribonucleic Acid; Genetic Processes; Pluripotent Stem Cells; Inheritance Patterns; Epigenomics; Cellular Microenvironment

近期论文

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van Wolfswinkel, J.C.*, Wagner, D.E.*, Reddien, P.W. (2014) Single cell analysis reveals functionally distinct classes within the planarian stem cell compartment. Cell Stem Cell 15, 326-339 van Wolfswinkel, J.C. Piwi and potency: PIWI proteins in animal stem cells and regeneration. (2014) Intergative and Comparative Biology 54, 700-713 van Wolfswinkel, J.C., Ketting, R.F. (2010) The role of small non-coding RNAs in genome stability and chromatin organization. Journal of Cell Science, 123, 1825-1839 van Wolfswinkel, J.C., Claycomb, J.M., Batista, P.J., Mello, C.C., Berezikov, E., and Ketting, R.F. (2009). CDE‑1 affects chromosome segregation through uridylation of CSR‑1-bound siRNAs. Cell 139, 135-148 Kamminga L.M.*, van Wolfswinkel J.C.*, Luteijn M.J.*, Kaaij L.J.T., Bagijn M.P., Sapetschnig A., Miska E.A., Berezikov E., Ketting R.F. (2012) Differential impact of the Hen1 homolog HENN-1 on 21U and 26G RNAs in the germline of Caenorhabditis elegans PLoS Genetics, 8 Robert, V.J., Sijen, T., van Wolfswinkel, J., and Plasterk, R.H. (2005). Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences. Genes and Development 19, 782-787 Carmell MA, Dokshin GA, Skaletsky H, Hu YC, van Wolfswinkel JC, Igarashi KJ, Bellott DW, Nefedov M, Reddien PW, Enders GC, Uversky VN, Mello CC, Page DC: A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes. Elife. 2016 Oct 8; 2016 Oct 8. PMID: 27718356 van Wolfswinkel JC: Piwi and potency: PIWI proteins in animal stem cells and regeneration. Integr Comp Biol. 2014 Oct; 2014 Jun 19. PMID: 24948137 van Wolfswinkel JC, Wagner DE, Reddien PW: Single-cell analysis reveals functionally distinct classes within the planarian stem cell compartment. Cell Stem Cell. 2014 Sep 4; 2014 Jul 10. PMID: 25017721 Srivastava M, Mazza-Curll KL, van Wolfswinkel JC, Reddien PW: Whole-body acoel regeneration is controlled by Wnt and Bmp-Admp signaling. Curr Biol. 2014 May 19; 2014 Apr 24. PMID: 24768051 Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA: MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation. Curr Biol. 2014 Apr 14; 2014 Mar 27. PMID: 24684932 Kamminga LM, van Wolfswinkel JC, Luteijn MJ, Kaaij LJ, Bagijn MP, Sapetschnig A, Miska EA, Berezikov E, Ketting RF: Differential impact of the HEN1 homolog HENN-1 on 21U and 26G RNAs in the germline of Caenorhabditis elegans. PLoS Genet. 2012; 2012 Jul 19. PMID: 22829772 van Wolfswinkel JC, Ketting RF: The role of small non-coding RNAs in genome stability and chromatin organization. J Cell Sci. 2010 Jun 1. PMID: 20484663 van Wolfswinkel JC, Claycomb JM, Batista PJ, Mello CC, Berezikov E, Ketting RF: CDE-1 affects chromosome segregation through uridylation of CSR-1-bound siRNAs. Cell. 2009 Oct 2. PMID: 19804759 Claycomb JM, Batista PJ, Pang KM, Gu W, Vasale JJ, van Wolfswinkel JC, Chaves DA, Shirayama M, Mitani S, Ketting RF, Conte D Jr, Mello CC: The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Cell. 2009 Oct 2. PMID: 19804758 Van Och FM, Van Loveren H, Van Wolfswinkel JC, Machielsen AJ, Vandebriel RJ: Assessment of potency of allergenic activity of low molecular weight compounds based on IL-1alpha and IL-18 production by a murine and human keratinocyte cell line. Toxicology. 2005 Jun 1. PMID: 15840424 Robert VJ, Sijen T, van Wolfswinkel J, Plasterk RH: Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences. Genes Dev. 2005 Apr 1; 2005 Mar 17. PMID: 15774721