Vaccarino, Flora Maria - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Flora Vaccarino graduated in Medicine at Padua University in Italy and studied neuropharmacology and cell biology at NIH as a research fellow before starting her Residency in Psychiatry at Yale University. After her residency, she studied developmental biology and genetics and was appointed Assistant Professor at Yale University. Her interests are the development of the mammalian the cerebral cortex, basal ganglia and connected forebrain regions as well as the regulation of neural stem cells in both embryonic and postnatal periods. Her lab has been investigating how genetic (i.e., tyrosine growth factor receptors like Fibroblast Growth Factors) and epigenetic factors (i.e., perinatal hypoxia, environmental enrichment) affect the proliferation the maturation of neural progenitor cells in mouse models. Recently she has been exploring how induced pluripotent stem cells (iPSCs) can be used to model developmental neuropsychiatric disorders including autism and Rett syndrome. With a group of colleagues, Dr. Vaccarino, now a full Professor at Yale University School of Medicine, founded in 2009 the “Program in Neurodevelopment and Regeneration” (http://medicine.yale.edu/neurodevelopment/index.aspx), a collaborative interdepartmental program at Yale University that is leading interdisciplinary studies on iPSCs, neural stem cells and human development.Dr. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE and the Brain Somatic Mosaicism Consortia. MD Padua University Medical University (1979) Resident Yale University, School of Medicine, Psychiatry Visiting Assistant Professor FIDIA-Georgetown Institute for the Neurosciences Research Fellow NIMH-Laboratory of Preclinical Pharmacology

研究领域

Central Nervous System Diseases; Mice, Inbred Strains; Mice, Transgenic; Neuroanatomy; Neurosciences; Patients; Regeneration; Developmental Biology; Living Donors; Psychiatry and Psychology

近期论文

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The PsychENCODE Project. The PsychENCODE Consortium, Akbarian, S., Liu, C., Knowles, J.A., Vaccarino, F.M., Farnham, P., Crawford, G.E., Jaffe, A.E., Pinto, D., Dracheva, S., Geschwind, D.H., Mill, J., Nairn, A.C., Abyzov, A., Pochareddy, S., Prabhakar, S., Weissman, S., Sullivan, P.F., State, M.W., Weng, Z., Peters, M.A., White, K., Gerstein, M.B., Senthil, G., Lehner, T., Sklar, P., Sestan, N.: The PsychENCODE Project. Nature Neuroscience, accepted for publication. Imbalance of Excitatory/Inhibitory Synaptic Protein Expression in iPSC-derived Neurons from FOXG1+/- Patients and in Foxg1+/- Mice Patriarchi, T., Amabile, S., Frullanti, E., Landucci, E., Lo Rizzo, C., Ariani, F., Costa, M., Olimpico, F., Hell, J. W., Vaccarino, F.M., Renieri, A., Meloni, I.: Imbalance of Excitatory/Inhibitory Synaptic Protein Expression in iPSC-derived Neurons from FOXG1+/- Patients and in Foxg1+/- Mice. European Journal of Human Genetics, in press. Contribution of maternal oxygenic state to the effects of chronic postnatal hypoxia on mouse body and brain development Salmaso, N., Dominguez, M., Kravitz, J., Komitova, M., Vaccarino, F.M. & Schwartz, M.L.: Contribution of maternal oxygenic state to the effects of chronic postnatal hypoxia on mouse body and brain development. Neurosci. Lett, in press. Altered expression of neuropeptides in FoxG1-null heterozygous mutant mice Frullanti, E., Amabile, S., Lolli, M.G., Bartolini, A., Livide, G., Landucci, E., Mari, F., Vaccarino, F.M., Ariani, F., Massimino, L., Renieri, A., Meloni, I.: Altered expression of neuropeptides in FoxG1-null heterozygous mutant mice. European Journal of Human Genetics, in press. What Does Immunology have to do with Brain Development and Neuropsychiatric Disorders? Leckman, J.F., Vaccarino, F.M. Editorial Commentary: What Does Immunology have to do with Brain Development and Neuropsychiatric Disorders? Brain Res, in press. Special Issue “Neuroimmunology in Health And Disease.” FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders Mariani, J., Coppola, G., Zhang, P., Abyzov, A., Provini, L., Tomasini, L., Amenduni, M., Szekely, A., Palejev, D., Wilson, M., Gerstein, M., Grigorenko, E., Chawarska, K., Pelphrey, K., Howe, J., Vaccarino, F.M.: FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders. Cell. (2015) 162(2):375-390. How animal models inform child and adolescent psychiatry Stevens, H. E., and Vaccarino, F.M.: How animal models inform child and adolescent psychiatry. Journal of the American Academy of Child and Adolescent Psychiatry (2015) 54(5):352-359. The Use of Stem Cells to Study Autism Spectrum Disorder Ardhanareeswaran, K., Coppola, G., and Vaccarino, F.M.: The Use of Stem Cells to Study Autism Spectrum Disorder. The Yale Journal of Biology and Medicine (2015) 88(1):5-16. Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome Xu, M., Kobets, A., Du, J.-C., Lennington, J.B., Li, L., Banasr, M., Duman, R.S., Vaccarino, F.M., DiLeone, R., Pittenger, C.: Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome. Proc. Natl. Acad. Sci. USA (2015) 112(3):893-8. Transcriptome Analysis of the Human Striatum in Tourette Syndrome Transcriptome Analysis of the Human Striatum in Tourette Syndrome. JB Lennington, G Coppola, Y Kataoka-Sasaki, TV Fernandez, D Palejev, Y Li, A Huttner, M Pletikos, N Sestan, JF Leckman, FM Vaccarino (2014). Biol Psychiatry. Tourette Syndrome. Lennington, J.B., Bloch, M.H., Scahill, L.D., Szuhay, D., Lombroso, P.J., and Vaccarino, F.M.: “Tourette Syndrome”. In: “Rosenberg’s Molecular and Genetic Basis of Neurological and Psychiatric Disease”, Elsevier (2014). Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. JG Kim, S Suyama, M Koch, S Jin, P Argente-Arizon, J Argente, ZW Liu, MR Zimmer, JK Jeong, K Szigeti-Buck, Y Gao, C Garcia-Caceres, CX Yi, N Salmaso, FM Vaccarino, J Chowen, S Diano, MO Dietrich, MH Tschöp, TL Horvath (2014). Nat Neurosci 17: 908-10. Neurogenesis and Maturation in Neonatal Brain Injury