Turner, Paul Eugene - Yale University - Biological & Biomedical Sciences

个人简介

The Turner group is interested in examining how viruses evolutionarily adapt to overcome new challenges, such as emergence on novel host species, transmission via new arthropod vectors, survival at elevated temperatures, or changes in host immunity. Their work also examines how viruses can be used in phage therapy as an alternative to traditional antibiotics, and in oncolytic therapy against cancers. They employ a wide variety of study systems, including bacteria-bacteriophage studies, and tissue culture experiments using molecular virology models such as vesicular stomatitis virus and Sindbis virus, and disease pathogens such as dengue virus. PhD Michigan State University, Microbial Ecology and Evolution (1995) BS University of Rochester, Biology (1988) Postdoc National Institutes of Health Postdoc University of Valencia, Spain Postdoc University of Maryland, College Park

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Predicting virus evolution: the relationship between genetic robustness and evolvability of thermotolerance Ogbunugafor, C.B., R.C. McBride and P.E. Turner. 2009. Predicting virus evolution: the relationship between genetic robustness and evolvability of thermotolerance. Cold Spring Harbor Symposia on Quantitative Biology 74:xx-xx. (In press). Evolutionary genomics of host adaptation in VSV Remold, S., A. Rambaut, and P.E. Turner. 2008. Evolutionary genomics of host adaptation in VSV. Molecular Biology and Evolution 25(6):1138-1147. Robustness promotes evolvability of thermotolerance in an RNA virus McBride, R.C., C.B. Ogbunugafor, and P.E. Turner. 2008. Robustness promotes evolvability of thermotolerance in an RNA virus. BMC Evolutionary Biology 8:231. Virus population extinction via ecological traps Dennehy, J.J., N.A. Friedenberg, Y.W. Yang, and P.E. Turner. 2007. Virus population extinction via ecological traps. Ecology Letters 10:230-240. Evolution of host specificity drives reproductive isolation among RNA viruses Duffy, S., C. L. Burch, and P.E. Turner. 2007. Evolution of host specificity drives reproductive isolation among RNA viruses. Evolution 61:2614-2622. Morley VJ, Turner PE: Dynamics of molecular evolution in RNA virus populations depend on sudden versus gradual environmental change. Evolution. 2017 Apr; 2017 Feb 14. PMID: 28121018 Chan BK, Brown K, Kortright KE, Mao S, Turner PE: Extending the lifetime of antibiotics: how can phage therapy help? Future Microbiol. 2016 Sep; 2016 Aug 22. PMID: 27545690 McDonald SM, Nelson MI, Turner PE, Patton JT: Reassortment in segmented RNA viruses: mechanisms and outcomes. Nat Rev Microbiol. 2016 Jul; 2016 May 23. PMID: 27211789 Chan BK, Sistrom M, Wertz JE, Kortright KE, Narayan D, Turner PE: Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa. Sci Rep. 2016 May 26; 2016 May 26. PMID: 27225966 Shapiro JW, Williams ES, Turner PE: Evolution of parasitism and mutualism between filamentous phage M13 and Escherichia coli. PeerJ. 2016; 2016 May 24. PMID: 27257543 Berg JM, Bhalla N, Bourne PE, Chalfie M, Drubin DG, Fraser JS, Greider CW, Hendricks M, Jones C, Kiley R, King S, Kirschner MW, Krumholz HM, Lehmann R, Leptin M, Pulverer B, Rosenzweig B, Spiro JE, Stebbins M, Strasser C, Swaminathan S, Turner P, Vale RD, VijayRaghavan K, Wolberger C: SCIENTIFIC COMMUNITY. Preprints for the life sciences. Science. 2016 May 20. PMID: 27199406 Williams ES, Morales NM, Wasik BR, Brusic V, Whelan SP, Turner PE: Repeatable Population Dynamics among Vesicular Stomatitis Virus Lineages Evolved under High Co-infection. Front Microbiol. 2016; 2016 Mar 31. PMID: 27065953 Wasik BR, Muñoz-Rojas AR, Okamoto KW, Miller-Jensen K, Turner PE: Generalized selection to overcome innate immunity selects for host breadth in an RNA virus. Evolution. 2016 Feb; 2016 Jan 20. PMID: 26882316 Morley VJ, Sistrom M, Usme-Ciro JA, Remold SK, Turner PE: Evolution in spatially mixed host environments increases divergence for evolved fitness and intrapopulation genetic diversity in RNA viruses. Virus Evol. 2016 Jan; 2016 Jan 20. PMID: 27774292 Sistrom M, Park D, O'Brien HE, Wang Z, Guttman DS, Townsend JP, Turner PE: Genomic and Gene-Expression Comparisons among Phage-Resistant Type-IV Pilus Mutants of Pseudomonas syringae pathovar phaseolicola. PLoS One. 2015; 2015 Dec 15. PMID: 26670219 Morley VJ, Mendiola SY, Turner PE: Rate of novel host invasion affects adaptability of evolving RNA virus lineages. Proc Biol Sci. 2015 Aug 22. PMID: 26246544 Walther V, Hiley CT, Shibata D, Swanton C, Turner PE, Maley CC: Can oncology recapitulate paleontology? Lessons from species extinctions. Nat Rev Clin Oncol. 2015 May; 2015 Feb 17. PMID: 25687908 Pesko K, Voigt EA, Swick A, Morley VJ, Timm C, Yin J, Turner PE: Genome rearrangement affects RNA virus adaptability on prostate cancer cells. Front Genet. 2015; 2015 Apr 1. PMID: 25883601 Foxman EF, Storer JA, Fitzgerald ME, Wasik BR, Hou L, Zhao H, Turner PE, Pyle AM, Iwasaki A: Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells. Proc Natl Acad Sci U S A. 2015 Jan 20; 2015 Jan 5. PMID: 25561542 Turner PE, Williams ES, Okeke C, Cooper VS, Duffy S, Wertz JE: Antibiotic resistance correlates with transmission in plasmid evolution. Evolution. 2014 Dec; 2014 Nov 24. PMID: 25351426