Turk, Benjamin E - Yale University - Biological & Biomedical Sciences

个人简介

PhD Massachusetts Institute of Technology (1999) BA Oberlin College (1990) Postdoc Harvard Medical School

研究领域

Pharmacology; Protein Kinases; Protein Engineering; Peptide Library; Proteomics; Molecular Mechanisms of Pharmacological Action; Carcinogenesis

近期论文

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Rational redesign of a functional protein kinase-substrate interaction Chen, C., Nimlamool, W., Miller, C. J., Lou, H. J., Turk, B. E. Rational redesign of a functional protein kinase-substrate interaction. ACS Chem. Biol. Published online 2017 Mar 29. Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGFβ-dependent mechanisms Shi, X., Mihaylova, V. T., Kuruvilla, L., Chen, F., Viviano, S., Baldassarre, M., Sperandio, D., Martinez, R., Yue, P., Bates, J. G., Breckenridge, D. G., Schlessinger, J.*, Turk, B. E.*, Calderwood, D. A.* Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGFβ-dependent mechanisms. Proc. Natl. Acad. Sci. U.S.A. 113, E4558-66 (2016). Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity Howard, C., Hanson-Smith, V., Kennedy, K. J., Miller, C. J., Lou, H. J., Johnson, A. D., Turk, B. E.*, Holt, L. J.* Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity. eLife 3, e04126 (2014). Global analysis of human nonreceptor tyrosine kinase specificity using high-density peptide microarrays Deng, Y., Alicea-Velázquez, N. L., Bannwarth, L., Lehtonen, S. I., Boggon, T. J., Cheng, H. C., Hytönen, V. P., Turk, B. E. Global analysis of human nonreceptor tyrosine kinase specificity using high-density peptide microarrays. J. Proteome Res. 13, 4339-4346 (2014). Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity Chen, C., Ha, B. H., Thévenin, A. F., Lou, H. J., Zhang, R., Yip, K. Y., Peterson, J. R., Gerstein, M., Kim, P. M., Filippakopoulos, P., Knapp, S., Boggon, T. J., Turk, B. E. Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity. Mol. Cell 53, 140-147 (2014). Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs Mok, J., Kim, P. M., Lam, H. Y. K., Piccirillo, S., Zhou, X., Jeschke, G. R., Sheridan, D. L., Parker, S. A., Desai, V., Jwa, M., Cameroni, E., Niu, H., Good, M., Remenyi, A., Ma, J. N., Sheu, Y., Sassi, H. E., Sopko, R., Chan, C. S. M., De Virgilio, C., Hollingsworth, N. M., Lim, W. A., Stern, D. F., Stillman, B., Andrews, B. J., Gerstein, M. B., Snyder, M. and Turk, B. E. Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Sci. Signal. 3, ra12 (2010). Chen C, Nimlamool W, Miller CJ, Lou HJ, Turk BE: Rational Redesign of a Functional Protein Kinase-Substrate Interaction. ACS Chem Biol. 2017 May 19; 2017 Mar 29. PMID: 28314095 Tio CW, Omerza G, Phillips T, Lou HJ, Turk BE, Winter E: Ssp2 Binding Activates the Smk1 Mitogen-Activated Protein Kinase. Mol Cell Biol. 2017 May 15; 2017 May 2. PMID: 28223369 Cobbaut M, Derua R, Döppler H, Lou HJ, Vandoninck S, Storz P, Turk BE, Seufferlein T, Waelkens E, Janssens V, Van Lint J: Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop. Sci Rep. 2017 Apr 20; 2017 Apr 20. PMID: 28428613 Goldberg AB, Cho E, Miller CJ, Lou HJ, Turk BE: Identification of a Substrate-selective Exosite within the Metalloproteinase Anthrax Lethal Factor. J Biol Chem. 2017 Jan 20; 2016 Dec 1. PMID: 27909054 Shi X, Mihaylova VT, Kuruvilla L, Chen F, Viviano S, Baldassarre M, Sperandio D, Martinez R, Yue P, Bates JG, Breckenridge DG, Schlessinger J, Turk BE, Calderwood DA: Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms. Proc Natl Acad Sci U S A. 2016 Aug 2; 2016 Jul 18. PMID: 27432991 Mathea S, Abdul Azeez KR, Salah E, Tallant C, Wolfreys F, Konietzny R, Fischer R, Lou HJ, Brennan PE, Schnapp G, Pautsch A, Kessler BM, Turk BE, Knapp S: Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib. ACS Chem Biol. 2016 Jun 17; 2016 Mar 31. PMID: 26999302 Zhang YW, Turk BE, Rudnick G: Control of serotonin transporter phosphorylation by conformational state. Proc Natl Acad Sci U S A. 2016 May 17; 2016 May 2. PMID: 27140629 Hamill S, Lou HJ, Turk BE, Boggon TJ: Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases. Mol Cell. 2016 May 5. PMID: 27153537 Goldberg AB, Turk BE: Inhibitors of the Metalloproteinase Anthrax Lethal Factor. Curr Top Med Chem. 2016. PMID: 27072692 Miller CJ, Turk BE: Rapid Identification of Protein Kinase Phosphorylation Site Motifs Using Combinatorial Peptide Libraries. Methods Mol Biol. 2016. PMID: 26501912 Deng Y, Turk BE: Analysis of Protein Tyrosine Kinase Specificity Using Positional Scanning Peptide Microarrays. Methods Mol Biol. 2016. PMID: 26490465 Creixell P, Palmeri A, Miller CJ, Lou HJ, Santini CC, Nielsen M, Turk BE, Linding R: Unmasking determinants of specificity in the human kinome. Cell. 2015 Sep 24; 2015 Sep 17. PMID: 26388442 Creixell P, Schoof EM, Simpson CD, Longden J, Miller CJ, Lou HJ, Perryman L, Cox TR, Zivanovic N, Palmeri A, Wesolowska-Andersen A, Helmer-Citterich M, Ferkinghoff-Borg J, Itamochi H, Bodenmiller B, Erler JT, Turk BE, Linding R: Kinome-wide decoding of network-attacking mutations rewiring cancer signaling. Cell. 2015 Sep 24; 2015 Sep 17. PMID: 26388441