Townsend, Jeffrey - Yale University - Biological & Biomedical Sciences

个人简介

Professor Townsend received his Ph.D. in 2002 in organismic and evolutionary biology from Harvard University, under the advisement of Daniel Hartl. His Ph.D. was entitled "Population genetic variation in genome-wide gene expression: modeling, measurement, and analysis", and constituted the first population genetic analysis of genome-wide gene expression variation. After making use of the model budding yeast S. cerevisiae for his Ph.D. research, Dr. Townsend accepted an appointment as a Miller Fellow at the University of California-Berkeley in the Department of Plant and Microbial Biology, where he worked to develop molecular tools, techniques, and analysis methodologies for functional genomics studies with the filamentous fungal model species Neurospora crassa, co-advised by Berkeley fungal evolutionary biologist John Taylor and molecular mycologist Louise Glass. In 2004, he accepted his first appointment as an Assistant Professor in the Department of Molecular and Cell Biology at the University of Connecticut. In 2006 he was appointed as an Assistant Professor the Department of Ecology and Evolutionary Biology at Yale University, and in 2013 he was appointed as an Associate Professor of Biostatistics in the Yale School of Public Health. PhD Harvard University, Organismic & Evolutionary Biology (2002) ScB Brown University, Biology (1994) Miller Postdoctoral Fellw University of California, Berkeley

研究领域

Algorithms; Bacteria; Bacterial Infections and Mycoses; Beer; Bread; Cell Transformation, Neoplastic; Coccidioidomycosis; Computing Methodologies; Biological Evolution; Fungi; Genetic Engineering; Microbiological Phenomena; Models, Genetic; Models, Theoretical; Mycoses; Neoplasm Metastasis; Neoplasms; Phylogeny; Viruses; Wine; Models, Statistical; Likelihood Functions; Logistic Models; Polymerase Chain Reaction; Sequence Analysis, DNA; Nonlinear Dynamics; Molecular Epidemiology; Gene Transfer Techniques; Crops, Agricultural; Evolution, Molecular; Nature; Sequence Analysis, Protein; Gene Expression Profiling; Public Health Informatics; Microarray Analysis; Genetic Speciation; Host-Pathogen Interactions; Genetic Phenomena; Mathematical Concepts; Metabolic Phenomena; Organisms; Phenomena and Processes

近期论文

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Early and multiple origins of metastatic lineages within primary tumors Zhao ZM, Zhao B, Bai Y, Iamarino A, Gaffney SG, Schlessinger J, Lifton RP, Rimm DL, Townsend JP. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2140-5. The Impact of Enhanced Screening and Treatment on Hepatitis C in the United States Durham DP, Skrip LA, Bruce RD, Vilarinho S, Elbasha EH, Galvani AP, Townsend JP. Clin Infect Dis. 2016 Feb 1;62(3):298-304. Inferring the origin of metastases from cancer phylogenies Hong W.S., M. Shpak, J.P. Townsend, 2015. Cancer Research 75(19):4021–4025 Impact of bed capacity on spatiotemporal shifts in Ebola transmission Townsend JP, Skrip LA, Galvani AP. Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14125-6. A comprehensive phylogeny of birds (Aves) using targeted next-generation DNA sequencing Prum RO, Berv JS, Dornburg A, Field DJ, Townsend JP, Lemmon EM, Lemmon AR. Nature. 2015 Oct 22;526(7574):569-73. Epidemiological and viral genomic sequence analysis of the 2014 ebola outbreak reveals clustered transmission. Scarpino SV, Iamarino A, Wells C, Yamin D, Ndeffo-Mbah M, Wenzel NS, Fox SJ, Nyenswah T, Altice FL, Galvani AP, Meyers LA and Townsend JP, 2015. Clinical Infectious Diseases 60(7):1079-1082. Gene expression evolves under a House-of-Cards model of stabilizing selection Hodgins-Davis A., D.P. Rice, and J.P. Townsend, 2015. Molecular Biology and Evolution 32(8): 2130–2140. Probabilistic uncertainty analysis of epidemiological modeling to guide public health intervention policy Gilbert, J.A., L.A. Meyers, A.P. Galvani, and J.P. Townsend (2014). Probabilistic uncertainty analysis of epidemiological modeling to guide public health intervention policy. Epidemics 6: 37-45. Yeast response to LA virus indicates coadapted global gene expression during mycoviral infection. McBride, R. C., Boucher, N., Park, D. S., Turner, P. E., & Townsend, J. P. (2013). Yeast response to LA virus indicates coadapted global gene expression during mycoviral infection. FEMS yeast research, 13(2), 162-179. Phylogenetic signal and noise: predicting the power of a dataset to resolve phylogeny. Townsend J.P., Z. Su, and Y.I. Tekle (2012). Phylogenetic signal and noise: predicting the power of a dataset to resolve phylogeny. Systematic Biology 61(5): 835-849. Assessing the probability of detection of horizontal gene transfer events in bacterial populations. Townsend, J. P., Bøhn, T., & Nielsen, K. M. (2012). Assessing the probability of detection of horizontal gene transfer events in bacterial populations. Frontiers in microbiology, 3. LOX: inferring Level Of eXpression from diverse methods of census sequencing. Zhang, Z., López-Giráldez, F., & Townsend, J. P. (2010). LOX: inferring Level Of eXpression from diverse methods of census sequencing. Bioinformatics, 26(15), 1918-1919. Chicago Maximum-likelihood model averaging to profile clustering of site types across discrete linear sequences.