Tattersall, Peter John - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Tattersall received his B.Sc. in Molecular Biology from the University of Glasgow, Scotland in 1968, and his doctorate from University College, London, England, in 1971, for studies on parvoviral DNA structure, replication and S-phase dependence, carried out at the Imperial Cancer Research Fund (ICRF), now Cancer UK. Then followed two years of postdoctoral fellowship at the Roche Institute of Molecular Biology, in Nutley, New Jersey, where he worked out the structural protein strategy of these viruses, and then two further years in Yale University’s Molecular Biophysics and Biochemistry Department, where he formulated the rolling hairpin model for parvoviral DNA replication. In 1975, he returned to the UK, working at the ICRF’s Mill Hill Laboratories on parvoviral interactions with differentiating cells. He moved back to Yale University in 1979, initially on the faculty of the Department of Genetics and then in Laboratory Medicine, where he was appointed professor in 1993. His laboratory continues to focus its efforts on understanding the basis of selective oncotropism of rodent parvoviruses for human tumor cells, and the molecular mechanisms by which mammalian parvoviruses target and enter particular cell types, express their genes, take over their host cells and replicate their own DNA. PhD University of London (1971) BSc (Hon) University of Glasgow, Molecular Biology (1968) Postdoc Yale University Postdoc Roche Institute of Molecular Biology

研究领域

Dependovirus; Biochemistry; Eukaryotic Cells; Genetics; Melanoma, Experimental; Mice, Mutant Strains; Medical Laboratory Science; Parvovirus; Erythrovirus; Oncolytic Virotherapy; Oncolytic Viruses; Mice; Bocavirus; Viral Structures; Immunomodulation

近期论文

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Complementation for an essential ancillary non-structural protein function across parvovirus genera. Mihaylov, I.S., Cotmore, S.F., & Tattersall, P. Complementation for an essential ancillary non-structural protein function across parvovirus genera. Virology. 468-470:226-237, 2014. Parvoviral left-end hairpin ears are essential during infection for establishing a functional intranuclear transcription template and for efficient progeny genome encapsidation. Li, L., Cotmore, S.F., & Tattersall, P. Parvoviral left-end hairpin ears are essential during infection for establishing a functional intranuclear transcription template and for efficient progeny genome encapsidation. J. Virol. 87:10501-14, 2013. Distinct host cell fates for human malignant melanoma targeted by oncolytic rodent parvoviruses. Vollmers, E.M., & Tattersall, P. Distinct host cell fates for human malignant melanoma targeted by oncolytic rodent parvoviruses. Virology, 446:37-48, 2013. Parvovirus evades interferon-dependent viral control in primary mouse embryonic fibroblasts. Mattei, L.M., Cotmore, S.F., Tattersall, P., & Iwasaki, A. Parvovirus evades interferon-dependent viral control in primary mouse embryonic fibroblasts. Virology, 442:20-7, 2013 Mutations at the base of the icosahedral five-fold cylinders of Minute Virus of Mice induce 3'-to-5' genome uncoating and critically impair entry functions. Cotmore, S.F. & Tattersall, P. Mutations at the base of the icosahedral five-fold cylinders of Minute Virus of Mice induce 3'-to-5' genome uncoating and critically impair entry functions. J. Virol., 86: 69-80, 2012. The parvoviral capsid controls an intracellular phase of infection essential for efficient killing of stepwise-transformed human fibroblasts. Paglino, J. & Tattersall, P. The parvoviral capsid controls an intracellular phase of infection essential for efficient killing of stepwise-transformed human fibroblasts. Virology, 416:32-41, 2011. Structure of a packaging-defective mutant of Minute Virus of Mice indicates that the genome is packaged via a pore at a 5-fold axis. Plevka, P., Hafenstein, S., Li, L., D'Abramo, A. Jr., Cotmore, S.F., Rossmann, M.G., & Tattersall P. Structure of a packaging-defective mutant of Minute Virus of Mice indicates that the genome is packaged via a pore at a 5-fold axis. J. Virol., 85:4822-7, 2011. Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM). Ruiz, Z., Mihaylov, I.S., Cotmore, S.F., & Tattersall, P. Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM). Virology, 410:375-84, 2011. Structures of minute virus of mice replication initiator protein N-terminal domain: Insights into DNA nicking and origin binding Tewary, S.K., Liang, L., Lin, Z., Lynn, A., Cotmore, S.F., Tattersall, P., Zhao, H. & Tang, L. Virology 476:61-71, 2015. Meir C, Mincberg M, Rostovsky I, Tal S, Vollmers EM, Levi A, Tattersall P, Davis C: The MVMp P4 promoter is a host cell-type range determinant in vivo. Virology. 2017 Jun; 2017 Apr 6. PMID: 28391161 Nakaya Y, Stavrou S, Blouch K, Tattersall P, Ross SR: In Vivo Examination of Mouse APOBEC3- and Human APOBEC3A- and APOBEC3G-Mediated Restriction of Parvovirus and Herpesvirus Infection in Mouse Models. J Virol. 2016 Sep 1; 2016 Aug 12. PMID: 27356895 Tewary SK, Liang L, Lin Z, Lynn A, Cotmore SF, Tattersall P, Zhao H, Tang L: Structures of minute virus of mice replication initiator protein N-terminal domain: Insights into DNA nicking and origin binding. Virology. 2015 Feb; 2014 Dec 18. PMID: 25528417 Cotmore SF, Tattersall P: Parvoviruses: Small Does Not Mean Simple. Annu Rev Virol. 2014 Nov; 2014 Jul 9. PMID: 26958732 Mihaylov IS, Cotmore SF, Tattersall P: Complementation for an essential ancillary non-structural protein function across parvovirus genera. Virology. 2014 Nov; 2014 Sep 6. PMID: 25194919 Vollmers EM, D'Abramo A Jr, Cotmore SF, Tattersall P: Genome sequence of tumor virus x, a member of the genus protoparvovirus in the family parvoviridae. Genome Announc. 2014 Jul 31; 2014 Jul 31. PMID: 25081268 Cotmore SF, Agbandje-McKenna M, Chiorini JA, Mukha DV, Pintel DJ, Qiu J, Soderlund-Venermo M, Tattersall P, Tijssen P, Gatherer D, Davison AJ: The family Parvoviridae. Arch Virol. 2014 May; 2013 Nov 9. PMID: 24212889