Takyar, Shervin - Yale University - Biological & Biomedical Sciences

个人简介

I did my PhD in microbiology and moleculatr biology in The University of Queensland, Australia. During my PhD I worked and published on a variety of projects including developing a new lentiviral vector based on JDV (Jembrana Disease Virus), translational regulation in HCV by small RNA-binding molecules and the viral core protein, and RNA-protein interactions in positive strand RNA viruses. During this time I was also involved in cloning the Australian isolate of HCV with Dr Eric Gowans. My findings in these projects were published in a variety of journal including PNAS, Hepatology, and Journal of Molecular Biology.My next stop was a postdoctoral fellowship with Prof. Harry Noller at the RNA Center in UCSC where I delved deeper into the RNA world and studied the helicase activity of the ribosome during translation. Our work was well received and published in Cell. I started my Internal Medicine residency at the State University of New York (SUNY) at Buffalo in 2003. During the last year of my residency I took part in a research project led by Dr Sands on the role of TIMP-1 in reactive airway disease. Our work was published in Clinical Immunology. I was then recruited to the Pulmonary Critical Care Fellowship at Yale in 2007, and worked with Dr J Elias to set up a platform for analyzing the role of microRNAs in the lung disease using the transgenic models that have been developed in his lab. I started this work on an inducible, lung-specific, VEGF transgenic model and within the first year of the project found a microRNA that was regulated by VEGF and mediated the effects of this cytokine in the lung. Based on these findings we filed a patent on the diagnsostic and therapeutic use of miR-1 in lung disease. I received a K99/R00 award in the third year of my clinical fellowship for my work on this project. I was directly recruited as a tenure-track Assistant Professor in the Yale Pulmonary, Critical Care and Sleep Medicine Section at the end of my fellowship. Since starting my tenure track position in 2010 I have been awarded the AAP (American Association of Physicians) Junior Investigator Award for my work on microRNAs in the lung and have given invited presentations at various international conferences. Our work on the role of VEGF-miR-1 axis in lung Th2 inflammation was published in Journal of Experimental Medicine. I successfully transitioned to the R00 (Independent investigator) phase of my NIH grant in 2013. I have recruited and worked with two postdoctoral fellows and three Associate Research Scientists over the last three years. My research currently focuses on the role of vascular non-coding RNAs in Th2 inflammation, lung injury and cancer. PhD University of Queensland (2002) MD Iran University of Medical Sciences (1995) Fellow Yale University School of Medicine Resident State University of New York - Buffalo Fellow University of California at San Cruz PG1 University of Queensland Board Certification AB of Internal Medicine, Internal Medicine (2007) Board Certification AB of Internal Medicine, Pulmonary Disease (2012)

研究领域

Asthma; Immunity, Cellular; Macrophage Activation; Neoplasms; Angiogenesis Inhibitors; MicroRNAs; Vascular Endothelial Growth Factor A

近期论文

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VEGF controls lung Th2 inflammation via the miR-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin axis. Takyar S, Vasavada H, Zhang JG, Ahangari F, Lee CG, Niu N, Liu Q, Cohn L, Elias JA. 'VEGF Controls Lung Th2 Inflammation Via the Mir-1-Mpl (Myeloproliferative Leukemia Virus Oncogene)-P-Selectin Axis', Journal of Eexperimental Medicine, 210 (2013), 1993-2010. RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism. Ma B, Dela Cruz CS, Hartl D, Kang MJ, Takyar S, Homer RJ, Lee CG, Elias JA. RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism. Am J Respir Crit Care Med. 2011 May 15;183(10):1322-35 mRNA helicase activity of the ribosome. Takyar S, Hickerson RP, Noller HF. mRNA helicase activity of the ribosome, Cell, 2005, 120:49-58?. Role of chitin and chitinase/chitinase-like proteins in inflammation,tissue remodeling, and injury. Lee CG, Da Silva CA, Dela Cruz CS, Ahangari F, Ma B, Kang MJ, He CH, Takyar S, Elias JA. Role of chitin and chitinase/chitinase-like proteins in inflammation,tissue remodeling, and injury. Annu Rev Physiol. 2011 Mar 17;73:479-501. Vitamin B12 and hepatitis C: molecular biology and human pathology. Takyar S and Lott WB, Tuppen J, Crawford DHG, Harrison M, Sloots TP, Gowans EJ. Vitamin B12 and hepatitis C: molecular biology and human pathology, Proceedings of the National Academy of Sciences (PNAS), 2001, 98:4916-4921 Vitamin B12 stalls the 80 S ribosomal complex on the hepatitis C internal ribosome entry site. Takyar S, Gowans EJ, Lott WB. Vitamin B12 stalls the 80 S ribosomal complex on the hepatitis C internal ribosome entry site, Journal of Molecular Biology, 2002, 319:1-8. Specific detection of minus-strand hepatitis C virus RNA by reverse-transcription polymerase chain reaction on PolyA(+)-purified RNA. Takyar S, Li DS, Wang YH, Trowbridge R, Gowans EJ. Specific detection of minus strand hepatitis C virus RNA by RT-PCR on a polyA purified RNA, Hepatology, 2000, 32:382-387. Takyar S, Zhang Y, Haslip M, Jin L, Shan P, Zhang X, Lee PJ: An endothelial TLR4-VEGFR2 pathway mediates lung protection against oxidant-induced injury. FASEB J. 2016 Mar; 2015 Dec 11. PMID: 26655705 Pimienta G, Fok V, Haslip M, Nagy M, Takyar S, Steitz JA: Proteomics and Transcriptomics of BJAB Cells Expressing the Epstein-Barr Virus Noncoding RNAs EBER1 and EBER2. PLoS One. 2015; 2015 Jun 29. PMID: 26121143 Ahangari F, Sood A, Ma B, Takyar S, Schuyler M, Qualls C, Dela Cruz CS, Chupp GL, Lee CG, Elias JA: Chitinase 3-like-1 regulates both visceral fat accumulation and asthma-like Th2 inflammation. Am J Respir Crit Care Med. 2015 Apr 1. PMID: 25629580 Takyar S, Vasavada H, Zhang JG, Ahangari F, Niu N, Liu Q, Lee CG, Cohn L, Elias JA: VEGF controls lung Th2 inflammation via the miR-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin axis. J Exp Med. 2013 Sep 23; 2013 Sep 16. PMID: 24043765 Lee CG, Ma B, Takyar S, Ahangari F, Delacruz C, He CH, Elias JA: Studies of vascular endothelial growth factor in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2011 Nov. PMID: 22052929 Lee CG, Da Silva CA, Dela Cruz CS, Ahangari F, Ma B, Kang MJ, He CH, Takyar S, Elias JA: Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury. Annu Rev Physiol. 2011. PMID: 21054166