Sweasy, Joann Balazs - Yale University - Biological & Biomedical Sciences

个人简介

PhD Rutgers University (1989) BA Beaver College, Biology and Chemistry (1980) Postdoctoral Research Fellow University of Washington, Seattle, WA Graduate Research Fellow Rutgers University,Piscataway, NJ Senior Staff Microbiologist Merck and Company, Rahway, NJ Undergraduate Research Assistant, Beaver College, Glenside, PA Postdoctoral Fellow University of Washington, Seattle, WA

研究领域

DNA Repair; DNA Replication; Genetics; Mutagenesis; Radiation Oncology; Carcinogenesis

近期论文

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Accumulation of abasic sites induces genomic instability in normal human gastric epithelial cells during Helicobacter pylori infection. Kidane D, Murphy DL, Sweasy JB. Accumulation of abasic sites induces genomic instability in normal human gastric epithelial cells during Helicobacter pylori infection. Oncogenesis. 2014; 3:e128 A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation. Sjolund A, Nemec AA, Paquet N, Prakash A, Sung P, Doublié S, Sweasy JB. A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation. PLoS Genet. 2014; 10(11):e1004753 Fluorescence resonance energy transfer studies of DNA polymerase β: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection. Towle-Weicksel JB, Dalal S, Sohl CD, Doublié S, Anderson KS, Sweasy JB. Fluorescence resonance energy transfer studies of DNA polymerase ß: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection. J Biol Chem. 2014; 289(23):16541-50 Mutation of POLB causes lupus in mice. Senejani AG, Liu Y, Kidane D, Maher SE, Zeiss CJ, Park HJ, Kashgarian M, McNiff JM, Zelterman D, Bothwell AL, Sweasy JB. Mutation of POLB causes lupus in mice. Cell Rep. 2014; 6(1):1-8 The E295K cancer variant of human polymerase ß favors the mismatch conformational pathway during nucleotide selection. Eckenroth BE, Towle-Weicksel JB, Sweasy JB, Doublié S. The E295K cancer variant of human polymerase ß favors the mismatch conformational pathway during nucleotide selection. J Biol Chem. 2013; 288(48):34850-60 Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation. Galick HA, Kathe S, Liu M, Robey-Bond S, Kidane D, Wallace SS, Sweasy JB. Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation. Proc Natl Acad Sci U S A. 2013 ;110(35):14314-9. A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation. Yamtich J, Nemec AA, Keh A, Sweasy JB. A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation. PLoS Genet. 2012;8(11):e1003052. doi: 10.1371/journal.pgen.1003052. Lokanga RA, Senejani AG, Sweasy JB, Usdin K: Heterozygosity for a hypomorphic Polβ mutation reduces the expansion frequency in a mouse model of the Fragile X-related disorders. PLoS Genet. 2015 Apr; 2015 Apr 17. PMID: 25886163