Sutton, Richard - Yale University - Biological & Biomedical Sciences

个人简介

After finishing his undergraduate studies at Brown University, Dr. Sutton enrolled in the MSTP at Stanford, where he obtained his PhD degree with Dr. John Boothroyd, working on African trypanosomes. He then completed a categorical residency in internal medicine at the Hospital of the University of Pennsylvania and a fellowship in infectious diseases at UCSF. After post-doctoral stints with Drs. Harold Varmus, Dan Littman, and Pat Brown in which he worked on HTLV cell binding and entry and the development of HIV-based gene therapy vectors, he joined the faculty at Baylor College of Medicine. In 2008 he was recruited to Yale to continue his work on HIV replication and lentiviral vectors. Dr. Sutton spends approximately 50% of his time at the research bench and 25% in the clinical setting, both out-patient and in-patient. Currently he is also the chief of ID at VACT in West Haven. MD/PhD Stanford University School of Medicine (1989) Post-doctoral fellow UCSF then Stanford University Fellow UC San Francisco Resident Hospital University of Pennsylvania Board Certification AB of Internal Medicine, Infectious Disease (1994, recertified: 2014)

研究领域

HIV; Molecular Biology; Infectious Disease Medicine

近期论文

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UBXN1 Interferes with Rig-I-like Receptor-Mediated Antiviral Immune Response by Targeting MAVS Wang, P. et al. UBXN1 Interferes with Rig-I-like Receptor-Mediated Antiviral Immune Response by Targeting MAVS. Cell Reports, in press. Human CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells. Elinav, H. et al. Human CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells. J. Virology 86: 12053-68, 2012. High level production of replication-defective human immunodeficiency type 1 virus vector particles using helper-dependent adenovirus vectors. Hu, Y, O’Boyle, K, Palmer, D, Ng, P, & Sutton, RE. High level production of replication-defective human immunodeficiency type 1 virus vector particles using helper-dependent adenovirus vectors. Mol Ther-Methods & Clin Development, in press. Increased levels of MIPs result in resistance to R5-tropic HIV-1 in a subset of Elite Controllers. Walker, WE, Kurscheid, S, Joshi, S, Lopez, CA, Goh, G, Choi, M, Barakat, L, Francis, J, Ann Fisher, A, Kozal, M, Zapata, H, Shaw, A, Lifton, R, Sutton, RE#, & Fikrig, EF#. Increased levels of MIPs result in resistance to R5-tropic HIV-1 in a subset of Elite Controllers. Journal of Virology, in press. #Co-senior authors. Adenovirus-Vectored Broadly Neutralizing Antibodies Directed Against gp120 Prevent Human Immunodeficiency Virus Type 1 Acquisition in Humanized Mice Liu, S, Jackson, A, Beloor, J, Kumar, P, & Sutton, R. Adenovirus-vectored broadly neutralizing antibodies directed against gp120 prevent HIV-1 acquisition in humanized mice, Hum Gene Ther, in press. Hu Y, O'Boyle K, Auer J, Raju S, You F, Wang P, Fikrig E, Sutton RE: Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα. PLoS Pathog. 2017 Feb; 2017 Feb 2. PMID: 28152074 Zhang X, Justice AC, Hu Y, Wang Z, Zhao H, Wang G, Johnson EO, Emu B, Sutton RE, Krystal JH, Xu K: Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals. Epigenetics. 2016 Aug 12; 2016 Aug 12. PMID: 27672717 Ikediobi U, Sutton RE: Aspergillus fumigatus native valve infective endocarditis in an otherwise healthy adult. JMM Case Rep. 2016 Feb; 2016 Feb 18. PMID: 28348749 Liu S, Jackson A, Beloor J, Kumar P, Sutton RE: Adenovirus-Vectored Broadly Neutralizing Antibodies Directed Against gp120 Prevent Human Immunodeficiency Virus Type 1 Acquisition in Humanized Mice. Hum Gene Ther. 2015 Sep; 2015 Aug 11. PMID: 25953321 Farber SJ, Sutton RE: HIV+ patient on suppressive antiretroviral therapy with steroid injection-induced myopathy. AIDS. 2015 Jul 17. PMID: 26098599 Walker WE, Kurscheid S, Joshi S, Lopez CA, Goh G, Choi M, Barakat L, Francis J, Fisher A, Kozal M, Zapata H, Shaw A, Lifton R, Sutton RE, Fikrig E: Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers. J Virol. 2015 May; 2015 Mar 4. PMID: 25740989 Hu Y, O'Boyle K, Palmer D, Ng P, Sutton RE: High-level production of replication-defective human immunodeficiency type 1 virus vector particles using helper-dependent adenovirus vectors. Mol Ther Methods Clin Dev. 2015; 2015 Mar 18. PMID: 26029715 Parker CG, Dahlgren MK, Tao RN, Li DT, Douglass EF Jr, Shoda T, Jawanda N, Spasov KA, Lee S, Zhou N, Domaoal RA, Sutton RE, Anderson KS, Jorgensen WL, Krystal M, Spiegel DA: Illuminating HIV gp120-Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules. Chem Sci. 2014 Jun 1. PMID: 25379167 You F, Wang P, Yang L, Yang G, Zhao YO, Qian F, Walker W, Sutton R, Montgomery R, Lin R, Iwasaki A, Fikrig E: ELF4 is critical for induction of type I interferon and the host antiviral response. Nat Immunol. 2013 Dec; 2013 Nov 3. PMID: 24185615 Wang P, Yang L, Cheng G, Yang G, Xu Z, You F, Sun Q, Lin R, Fikrig E, Sutton RE: UBXN1 interferes with Rig-I-like receptor-mediated antiviral immune response by targeting MAVS. Cell Rep. 2013 Apr 25; 2013 Mar 28. PMID: 23545497 Elinav H, Wu Y, Coskun A, Hryckiewicz K, Kemler I, Hu Y, Rogers H, Hao B, Ben Mamoun C, Poeschla E, Sutton R: Human CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells. J Virol. 2012 Nov; 2012 Aug 29. PMID: 22933280 Scheideman EH, Marlatt SA, Xie Y, Hu Y, Sutton RE, DiMaio D: Transmembrane protein aptamers that inhibit CCR5 expression and HIV coreceptor function. J Virol. 2012 Oct; 2012 Jul 18. PMID: 22811524