Sun, Zhaoxia - Yale University - Biological & Biomedical Sciences

个人简介

PhD Yale University School of Medicine (1998) postdoctoral associate MIT

研究领域

Genetics; Kidney; Polycystic Kidney Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Zebrafish

近期论文

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Cystic kidney gene seahorse regulates cilia mediated processes and Wnt pathways. N. Kishimot, Y. Cao, A. Park and Z. Sun. (2008). Cystic kidney gene seahorse regulates cilia mediated processes and Wnt pathways. Developmental Cell 14:954-961. Zebrafish Tsc1 reveals functional interactions between the cilium and the Tor pathway. DiBella, Alice Park and Z. Sun. 2009. Zebrafish Tsc1 reveals functional interactions between the cilium and the Tor pathway. Human Molecular Genetics 18:595-606. Cilia localization is essential for in vivo functions of the Joubert syndrome protein Arl13b/Scorpion. N. A. Duldulao, S. Lee and Z.Sun. 2009. Cilia localization is essential for in vivo functions of the Joubert syndrome protein Arl13b/Scorpion. Development 136:4033-4042 Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. Ying Cao, Nicole Semanchik, Seung-Hyun Lee, Stefan Somlo, Paolo Emilio Barbano, Ronald Coifman and Zhaoxia Sun. 2009. Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. Proc Natl Acad Sci U S A. 106:21819-24. The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch. N. E. Hellman, Y. Liu, E. Merkel, C. Austin, S. Corre, D. R. Beier, Z. Sun, N. Sharma, B. K. Yoder, and I. A. Drummond. 2010. foxj1a regulates cilia function in response to injury and epithelial stretch. Proc Natl Acad Sci U S A. 107:18499-504. Intraflagella transport proteins are essential for cilia formation and for planar cell polarity. 6. Y. Cao, A. Park and Z. Sun. 2010. Intraflagella transport proteins are essential for cilia formation and for planar cell polarity. J. Am. Soc. Nephrol. 21:1326-1333. Qilin Is Essential for Cilia Assembly and Normal Kidney Development in Zebrafish Qilin Is Essential for Cilia Assembly and Normal Kidney Development in Zebrafish. J. Li and Z. Sun. 2011. Qilin Is Essential for Cilia Assembly and Normal Kidney Development in Zebrafish Qilin Is Essential for Cilia Assembly and Normal Kidney Development in Zebrafish. PLoS ONE 6 (11): e27365. A cell-based screen for inhibitors of flagella-driven motility in Chlamydomonas reveals a novel modulator of ciliary length and retrograde actin flow. B. D. Engel BD, H. Ishikawa, J. L. Feldman, C. W. Wilson, P. T. Chuang, J. Snedecor, J. Williams, Z. Sun, M. F. Marshall. 2011. A cell-based screen for inhibitors of flagella-driven motility in Chlamydomonas reveals a novel modulator of ciliary length and retrograde actin flow. Cytoskeleton 68:188-203. Torc1 signaling modulates cilia size and function through protein synthesis regulation. S. Yuan, J. Li, D. R. Diener, M. A. Choma, J. L. Rosenbaum and Z. Sun. 2012. Torc1 signaling modulates cilia size and function through protein synthesis regulation. Proc Natl Acad Sci U S A. 109:2021- [cover] PMC3277533 The γ-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism. D. Merrick, H. Chapin, J. E. Baggs, Z. Yu, S. Somlo, Z. Sun, J. B. Hogenesch, M. J. Caplan. 2012. The ?-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism. Dev Cell. 17:197-210. PMC3264829 Reptin/Ruvbl2 is a Lrrc6/Seahorse interactor essential for cilia motility. L. Zhao, S. Yuan, Y. Cao, S. Kallakuri, Y. Li, N. Kishimoto, L. DiBella and Z. Sun Proc Natl Acad Sci U S A, 2013, 110:12679-702. PMC3732945 IFT27, encoding a small GTPase component of IFT particles, is mutated in a consanguineous family with Bardet-Biedl syndrome. M. A Aldahmesh, Y. Li, A. Alhashem, S. Anazi1, H. Alkuraya, A. Al-Awaji, S. Sakati, A. Alkharashi, S. Alzahrani, S. A Al Hazzaa, Y. Xiong, Z. Sun* (*: co-corresponding authors), F. S Alkuraya* Human Molecular Genetics 2014, 23:3307-15. PMC4047285 Intraciliary calcium oscillations initiate vertebrate left-right asymmetry