Suarez, Yajaira - Yale University - Biological & Biomedical Sciences

个人简介

Yajaira studied Biochemistry and Molecular Biology at the University Autonoma of Madrid (1995). She did her PhD with Miguel Angel Lasuncion at the Hospital Ramón y Cajal and the University Autonoma de Madrid (Spain) (1996-2001). Yajaira also did two post-docs. The first one with Alberto Muñoz at the Instituto de Investigaciones Biomédicas "Alberto Sols" and the Consejo Superior de Investigaciones Científicas-Universidad Autonoma de Madrid (Spain) (2002-2005) and the second one with Jordan Pober and Bill Sessa at Yale University School of Medicine (2005-2009). In 2009, she was recruited as Research Assistant Professor in the Division of Cardiology at New York University School of Medicine and then promoted to Assistant Professor of Medicine and Cell Biology in 2010. Yajaira is currently an Assistant Professor of Comparative Medicine and Pathology at Yale University School of Medicine (2013- ). PhD Universidad Autonoma, Madrid, Spain (2001) BS Universidad Autonoma, Madrid, Spain (1995) Post. Doc. Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid Post. Doc. Yale University School of Medicine

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Haskins JW, Zhang S, Means RE, Kelleher JK, Cline GW, Canfrán-Duque A, Suárez Y, Stern DF. Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake. Sci Signal. 2015 Nov 3;8(401):ra111. doi: 10.1126/scisignal.aac5124. Chamorro-Jorganes A, Lee MY, Araldi E, Landskroner-Eiger S, Fernández-Fuertes M, Sahraei M, Quiles de Rey M, van Solingen C, Ju Y, Fernández-Hernando C, Sessa WC and Suárez Y. VEGF-induced expression of miR-17~92 cluster in endothelial cells is mediated by ERK/ELK1 activation and regulates angiogenesis. Circ Res. 2015 Oct 15. pii: CIRCRESAHA.115.307408. [Epub ahead of print] Goedeke L, Rotllan N, Canfrán-Duque A, Aranda JF, Ramírez CM, Araldi E, Lin C-S, Anderson NN, Wagschal A, de Cabo R, Horton JD, Lasunción MA, Näär AM, Suárez Y and Fernández-Hernando C. MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels. Nat Med. 2015 Nov;21(11):1280-9. doi: 10.1038/nm.3949. Epub 2015 Oct 5. van Solingen C, Araldi E, Chamorro-Jorganes A, Fernández-Hernando C, Suárez Y. Improved repair of dermal wounds in mice lacking microRNA-155. J Cell Mol Med. (2014). [Epub ahead of print] Chamorro-Jorganes A, Araldi E, Noemi Rotllan, Daniel Cirera-Salinas, Suárez Y. Autoregulation of glypican-1 by intronic microRNA-149 fine-tunes the angiogenic response to fibroblast growth factor in human endothelial cells. J Cell Sci .127: 1169-1178 (2014) Chamorro-Jorganes A, Araldi E, Suárez Y. MicroRNAs as pharmacological targets in endothelial cell function and dysfunction. Pharmacol Res. 75: 15-27 (2013) Stahlhut C, Suárez Y, Lu J, Mishima Y, Giraldez AJ. miR-1 and miR-206 regulate angiogenesis by modulating VegfA expression in zebrafish. Development. 139(23):4356-64. (2012) Chamorro-Jorganes A, Araldi E, Penalva LO, Sandhu D, Fernández-Hernando C, Suárez Y. MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1. Arterioscler Thromb Vasc Biol. 31(11):2595-606. (2011) Suárez Y*, Rayner KJ*, Dávalos A, Parathath S, Fitzgerald ML, Tamehiro N, Fisher EA, Moore KJ, Fernández-Hernando C. "miR-33 Contributes to the Regulation of Cholesterol Homeostasis". Science. 328: 1570-1573 (2010) Suárez Y, Wang C, Manes TD, Pober JS. TNF-induced miRNAs Regulate TNF-induced expression of E-Selectin and ICAM-1 on Human Endothelial Cells: Feedback Control of Inflammation. Cutting Edge: J Immunol 184(1):21-5 (2010) Suárez Y, Fernández-Hernando C, Yu Y, Gerber SA, Harrison KD, Pober JS, Iruela-Arispe ML, Merkenschlager M and. Sessa WC. Dicer-dependent endothelial microRNAs are necessary for post-natal angiogenesis. PNAS 105(37):14082-14087, (2008) Suárez Y, Fernández-Hernando C, Pober JS, Sessa WC. Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells. Circ Res 100(8):1164-73, (2007)