Strobel, Scott A - Yale University - Biological & Biomedical Sciences

个人简介

Professor Strobel's laboratory investigates the structural and mechanistic basis of RNA enzymes, with particular attention to two systems: self-splicing introns and peptide bond formation by the ribosome. The overriding question being addressed is: How does RNA, which is composed of building blocks best suited for a role in the storage of genetic information, catalyze biologically essential chemical reactions? To explore this question, they use chemical, biochemical, and biophysical methods ranging from organic synthesis to X-ray crystallography. These complementary approaches provide high-resolution biochemical and structural information about the RNAs under investigation. Their results have revealed that RNA uses catalytic strategies that are strikingly similar to those of proteins, the more adept and more common catalyst within cells. This includes catalysis promoted by active-site metal ions and substrate-assisted catalysis involving chemical groups on the reaction substrates. Postdoctoral Fellow University of Colorado, Boulder, CO

研究领域

Biochemistry; Biophysics; Chemistry; Ribosomes; Biofuels; Endophytes; Chemicals and Drugs; Technology, Industry, Agriculture

近期论文

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K. D. Smith, S. V. Lipchock, T. D. Ames, R. R. Breaker and S. A. Strobel, Structural basis of ligand binding by a c-di-GMP riboswitch Nature Struc. Molec. Biol. (in press). J. C. Cochrane, S. V. Lipchock, K. D. Smith and S. A. Strobel Structural and chemical basis for glucosamine 6-phosphate binding and activating the glmS ribozyme, Biochemistry 48, 3239–3246 (2009). D. A. Kingery, E. Pfund, R. M. Voorhees, K. Okuda, I. Wohlgemuth, D. E. Kitchen, M. V. Rodnina, and S. A. Strobel. An uncharged amine in the transition state of the ribosomal peptidyl transfer reaction. Chem. & Biol. 15, 493-500 (2008). S. V. Lipchock and S. A. Strobel. A relaxed active site after exon ligation by the group I intron. Proc. Natl. Acad. Sci. U.S.A. 105, 5699-5704 (2008). Cochrane, J.C., Lipchock, S.V., and Strobel, S.A. (2007). Structural investigation of the GlmS ribozyme bound to its catalytic cofactor. Chem. & Biol. 14:97-105. Huang, K.S., Weinger, J.S., Butler, E.B., and Strobel, S.A. (2006). Regiospecificity of the peptidyl tRNA ester within the ribosomal P site. J. Amer. Chem. Soc. 128:3108-3109.