Strittmatter, Stephen M - Yale University - Biological & Biomedical Sciences

个人简介

Stephen M. Strittmatter earned his undergraduate degree from Harvard College, summa cum laude, in 1980. He completed M.D. and Ph.D. training at Johns Hopkins in 1986 with mentorship from Solomon H. Snyder, M.D. He then moved to Massachusetts General Hospital for a medical internship and an Adult Neurology residency. While at Massachusetts General Hospital, he worked as a Research Fellow with Mark Fishman, M.D., exploring the molecular basis of axonal guidance. After a year as Fellow, he served briefly as an Assistant Professor at Harvard Medical School before moving to Yale University in 1993. He currently holds the Vincent Coates Professorship of Neurology and co-founded the Yale Program in Cellular Neuroscience, Neurodegeneration and Repair. His research on axonal growth during development and regeneration has been recognized by honors from the Ameritec Foundation, the John Merck Fund, the Donaghue Foundation, the McKnight Foundation, the Jacob Javits Award of the NINDS and the American Academy of Neurology. MD Johns Hopkins University (1986) PhD Johns Hopkins University (1986) AB Harvard College (1980) Clinical and Research Fellow Harvard Medical School, Mass. General Hospital Resident Resident in Neurology, Massachusetts General Hospital Intern in Medicine Massachusetts General Hospital Board Certification AB of Psychiatry & Neurology, Neurology (1991)

研究领域

Alzheimer Disease; Axons; Dementia; Spinal Cord Injuries; Motor Neuron Disease; Regenerative Medicine

近期论文

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Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signaling in Alzheimer’s disease. Haas, L.T., Salazar, S.V., Kostylev, M., Um, J.W., Strittmatter, S.M. Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signaling in Alzheimer’s disease. Brain : a journal of neurology, Dec 14. pii: awv356. [Epub ahead of print] (2015). Erasure of Fear Memories is Prevented by Nogo Receptor 1 in Adulthood. Bhagat, S.M., Butler, S.S., Taylor, J.P., McEwen, B.S., Strittmatter, S.M. Erasure of Fear Memories is Prevented by Nogo Receptor 1 in Adulthood. Mol Psychiatry, Dec 1. doi: 10.1038/mp.2015.179. [Epub ahead of print] (2015). Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Kaufman AC, Salazar SV, Haas LT, Yang J, Kostylev MA, Jeng AT, Robinson SA, Gunther EC, van Dyck CH, Nygaard HB, Strittmatter SM. Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Ann Neurol. 77: 953-971 (2015). Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury. Zou Y, Stagi M, Wang X, Yigitkanli K, Siegel CS, Nakatsu F, Cafferty WB, Strittmatter SM. Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury. J Neurosci. 35:10429-10439 (2015). Intravitreal delivery of human NgR-Fc decoy protein regenerates axons after optic nerve crush and protects ganglion cells in glaucoma models. Wang X, Lin J, Arzeno A, Choi JY, Boccio J, Frieden E, Bhargava A, Maynard G, Tsai JC, Strittmatter SM. Intravitreal delivery of human NgR-Fc decoy protein regenerates axons after optic nerve crush and protects ganglion cells in glaucoma models. Invest Ophthalmol Vis Sci. 56:1357-1366 (2015). Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models. Kostylev MA, Kaufman AC, Nygaard HB, Patel P, Haas LT, Gunther EC, Vortmeyer A, Strittmatter SM. Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models. J Biol Chem. 290:17415-17438 (2015). Comprehensive corticospinal labeling with mu-crystallin transgene reveals axon regeneration after spinal cord trauma in ngr1-/- mice. Fink, K.L., Strittmatter, S.M., Cafferty, W.B.J. Comprehensive corticospinal labeling with mu-crystallin transgene reveals axon regeneration after spinal cord trauma in ngr1-/- mice. J Neurosci., 35:15403-15418 (2015). Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer's disease mouse model. Nygaard HB, Kaufman AC, Sekine-Konno T, Huh LL, Going H, Feldman SJ, Kostylev MA, Strittmatter SM. Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer's disease mouse model. Alzheimers Res Ther. 7:25 (2015). A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease. Nygaard HB, Wagner AF, Bowen GS, Good SP, MacAvoy MG, Strittmatter KA, Kaufman AC, Rosenberg BJ, Sekine-Konno T, Varma P, Chen K, Koleske AJ, Reiman EM, Strittmatter SM, van Dyck CH. A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease. Alzheimers Res Ther. 7:35 (2015). Plasticity of intact rubral projections mediates spontaneous recovery of function after corticospinal tract injury. Siegel CS, Fink KL, Strittmatter SM, Cafferty WBJ. Plasticity of intact rubral projections mediates spontaneous recovery of function after corticospinal tract injury. J Neurosci 35(4):1443-1457 (2015). Metabotropic Glutamate Receptor 5 is a Co-Receptor for Alzheimer Aß Oligomer Bound to Cellular Prion Protein. Um JW, Kaufman AC, Kostylev M, Heiss JK, Stagi M, Takahashi H, Kerrisk ME, Vortmeyer A, Wisniewski T, Koleske AJ, Gunther EC, Nygaard HB, Strittmatter SM. Metabotropic Glutamate Receptor 5 is a Co-Receptor for Alzheimer Aß Oligomer Bound to Cellular Prion Protein. Neuron, 79:887-902 (2013). Anatomical Plasticity of Adult Brain is Titrated by Nogo Receptor 1. Akbik FV, Bhagat SM, Patel RR, Cafferty WBJ, Strittmatter SM. Anatomical Plasticity of Adult Brain is Titrated by Nogo Receptor 1. Neuron, 77:859-866 (2013). Alzheimer Amyloid-ß Oligomer Bound to Post-Synaptic Prion Protein Activates Fyn to Impair Neurons.