Steitz, Thomas A - Yale University - Biological & Biomedical Sciences

个人简介

Prof. Thomas Steitz received a B.A. degree in chemistry from Lawrence College in Appleton, Wisconsin, and a Ph.D. degree in molecular biology and biochemistry from Harvard, with William Lipscomb. After a postdoctoral year at Harvard, he moved to the Medical Research Council Laboratory of Molecular Biology in Cambridge, England, to work as a Jane Coffin Childs fellow with David Blow. He next joined the Yale faculty, where he has remained, except for sabbatical work with Klaus Weber in Göttingen, Germany; Aaron Klug at Cambridge; John Abelson at the California Institute of Technology; and Thomas Cech and Olke Uhlenbeck at the University of Colorado. He has received the 2009 Nobel Prize in Chemistry, the Pfizer Prize from the American Chemical Society, the Lewis S. Rosenstiel Award for distinguished work in basic medical sciences, the 2001 Newcomb Cleveland Prize from the American Association for the Advancement of Science, the Lawrence University Lucia R. Briggs Distinguished Achievement Award, the 2006 Keio Medical Science Prize, and the 2007 Gairdner International Award. Dr. Steitz is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. He was recently elected a fellow of the American Association for the Advancement of Science. PhD Harvard University (1966) BA Lawrence College (1962) Jane Coffin Childs Postdoctoral Fellow Cambridge, England Postdoctoral Fellow Harvard University

研究领域

Biochemistry; Biophysics; DNA Replication; Nucleic Acids; Recombination, Genetic; Crystallography, X-Ray

近期论文

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The structure of T. aquaticus DNA polymerase III is distinct from eukaryotic replicative DNA polymerases. Bailey, S., Wing, R.A., and Steitz, T.A. (2006). The structure of T. aquaticus DNA polymerase III is distinct from eukaryotic replicative DNA polymerases. Cell 126:893-904. An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA. Schmeing, T.M., Huang, K.S., Strobel, S.A., and Steitz, T.A. (2005). An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA. Nature 438:520-524. Formation of the first peptide bond: the structure of EF-P bound to the 70S ribosome. Blaha G, Stanley RE, Steitz TA.Science. 2009 Aug 21;325(5943):966-70 The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation. Palioura S, Sherrer RL, Steitz TA, Söll D, Simonovic M. Science. 2009 Jul 17;325(5938):321-5. Simonovic M, Steitz TA. Biochim Biophys Acta. 2009 Jul 9. [Epub ahead of print] Steitz TA, Moore PB: Perspectives on the ribosome. Philos Trans R Soc Lond B Biol Sci. 2017 Mar 19. PMID: 28138074 Nguyen LA, Wang J, Steitz TA: Crystal structure of Pistol, a class of self-cleaving ribozyme. Proc Natl Acad Sci U S A. 2017 Jan 31; 2017 Jan 17. PMID: 28096403 Liu B, Steitz TA: Structural insights into NusG regulating transcription elongation. Nucleic Acids Res. 2017 Jan 25; 2016 Nov 29. PMID: 27899640 Zuo Y, Steitz TA: A structure-based kinetic model of transcription. Transcription. 2017 Jan; 2016 Sep 22. PMID: 27656764 Melnikov SV, Söll D, Steitz TA, Polikanov YS: Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome. Nucleic Acids Res. 2016 Jun 2; 2016 Apr 13. PMID: 27079977 Gagnon MG, Lin J, Steitz TA: Elongation factor 4 remodels the A-site tRNA on the ribosome. Proc Natl Acad Sci U S A. 2016 May 3; 2016 Apr 18. PMID: 27092003 Liu B, Zuo Y, Steitz TA: Structures of E. coli σS-transcription initiation complexes provide new insights into polymerase mechanism. Proc Natl Acad Sci U S A. 2016 Apr 12; 2016 Mar 28. PMID: 27035955 Gagnon MG, Roy RN, Lomakin IB, Florin T, Mankin AS, Steitz TA: Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition. Nucleic Acids Res. 2016 Mar 18; 2016 Jan 24. PMID: 26809677 Lomakin IB, Gagnon MG, Steitz TA: Antimicrobial peptides targeting bacterial ribosome. Oncotarget. 2015 Aug 7. PMID: 26300053 Bunick CG, Presland RB, Lawrence OT, Pearton DJ, Milstone LM, Steitz TA: Crystal Structure of Human Profilaggrin S100 Domain and Identification of Target Proteins Annexin II, Stratifin, and HSP27. J Invest Dermatol. 2015 Jul; 2015 Mar 11. PMID: 25760235 Polikanov YS, Starosta AL, Juette MF, Altman RB, Terry DS, Lu W, Burnett BJ, Dinos G, Reynolds KA, Blanchard SC, Steitz TA, Wilson DN: Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A. Mol Cell. 2015 Jun 4; 2015 May 28. PMID: 26028538 Roy RN, Lomakin IB, Gagnon MG, Steitz TA: The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin. Nat Struct Mol Biol. 2015 Jun; 2015 May 18. PMID: 25984972 Zuo Y, Steitz TA: Crystal structures of the E. coli transcription initiation complexes with a complete bubble. Mol Cell. 2015 May 7; 2015 Apr 9. PMID: 25866247 Polikanov YS, Melnikov SV, Söll D, Steitz TA: Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly. Nat Struct Mol Biol. 2015 Apr; 2015 Mar 16. PMID: 25775268 Liu B, Zuo Y, Steitz TA: Structural basis for transcription reactivation by RapA. Proc Natl Acad Sci U S A. 2015 Feb 17; 2015 Feb 2. PMID: 25646438 Lin J, Gagnon MG, Bulkley D, Steitz TA: Conformational changes of elongation factor G on the ribosome during tRNA translocation. Cell. 2015 Jan 15. PMID: 25594181