Spiegel, David Adam - Yale University - Biological & Biomedical Sciences

个人简介

David A. Spiegel was born in New York City, and grew up in Teaneck, New Jersey. From a very young age, he was fascinated by the chemistry and biology of small molecules, and at 16 began doing research in a neuroanesthesiology laboratory at the University of Iowa. He went on to attend Harvard University where he conducted research under the guidance of Professor Yoshito Kishi. After graduating from Harvard, David began in Yale University’s M.D./Ph.D. program. There he conducted graduate research in Professor John Wood’s laboratory focusing on developing synthetic approaches toward the phomoidrides. During the course of these studies, he discovered that trialkylborane-water complexes could function as H-atom donors in free radical reactions. Following graduation from Yale, Professor Spiegel moved back to Harvard for postdoctoral studies under the guidance of Professor Stuart L. Schreiber. There he focused on developing an oligomer-based method for small-molecule synthesis to enable the rapid assembly of skeletally diverse small molecules starting from simple monomers. David began as an assistant Professor at Yale in June of 2007. Since that time, he has been fortunate to be named recipient of the Camille and Henry Dreyfus New Faculty Award, the NIH Director’s New Innovator Award, Ellison Foundation New Scholar Award, Bill and Melinda Gates Foundations Grand Challenges Explorations Award and is the recipient of an Alfred P. Sloan Foundation Fellowship.

近期论文

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Synthetic Immunology to Engineer Human Immunity Spiegel DA. Synthetic Immunology to Engineer Human Immunity. Nature Chemical Biology. 2010; 6; 871-872. Chosen as one of eight recipients of the 2010 Grand Challenges in Chemical Biology Competition. A Biosynthetic Strategy for Re-engineering the S. aureus Cell Wall with Non-Native Small Molecules Nelson JW, Chamessian AG, McEnaney PJ, Kazmierczak BI, Spiegel DA. A Biosynthetic Strategy for Re-engineering the S. aureus Cell Wall with Non-Native Small Molecules. ACS Chemical Biology. 2010, 1147-1155. Remote Arene-Binding Site on Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules Zhang AX, Murelli RP, Barinka C, Michel J, Cocleaza A,** Jorgensen WL, Lubkowski J, Spiegel DA. A Remote Arene-Binding Site on Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules. Journal of the American Chemical Society. 2010, 12711-12716. Chemical control over immune recognition: A class of antibody-recruiting small molecules that target prostate cancer. Murelli RM, Zhang AX, Michel J, Jorgensen WL, Spiegel DA. Chemical control over immune recognition: A class of antibody-recruiting small molecules that target prostate cancer. Journal of the American Chemical Society. 2009; 131; 17090-17092. An antibody-recruiting small molecule that targets HIV gp120 Parker CG, Domaoal RA, Anderson KS, Spiegel DA. An antibody-recruiting small molecule that targets HIV gp120. Journal of the American Chemical Society. 2009;131: 16392-16394. This work was featured as a news story in ACS Chemical Biology, 2009, 4, 975. Sankaranarayanan S, Jamshed M, Kumar A, Skori L, Scandola S, Wang T, Spiegel D, Samuel MA: Glyoxalase Goes Green: The Expanding Roles of Glyoxalase in Plants. Int J Mol Sci. 2017 Apr 24; 2017 Apr 24. PMID: 28441779 Vastl J, Wang T, Trinh TB, Spiegel DA: Encoded Silicon-Chip-Based Platform for Combinatorial Synthesis and Screening. ACS Comb Sci. 2017 Apr 10; 2017 Mar 6. PMID: 28263558 Yehuda R, Spiegel D, Southwick S, Davis LL, Neylan TC, Krystal JH: What I have changed my mind about and why. Eur J Psychotraumatol. 2016; 2016 Nov 8. PMID: 27837585 O'Neill KM, Greenberg SL, Cherian M, Gillies RD, Daniels KM, Roy N, Raykar NP, Riesel JN, Spiegel D, Watters DA, Gruen RL: Bellwether Procedures for Monitoring and Planning Essential Surgical Care in Low- and Middle-Income Countries: Caesarean Delivery, Laparotomy, and Treatment of Open Fractures. World J Surg. 2016 Nov. PMID: 27351714 Nokin MJ, Durieux F, Peixoto P, Chiavarina B, Peulen O, Blomme A, Turtoi A, Costanza B, Smargiasso N, Baiwir D, Scheijen JL, Schalkwijk CG, Leenders J, De Tullio P, Bianchi E, Thiry M, Uchida K, Spiegel DA, Cochrane JR, Hutton CA, De Pauw E, Delvenne P, Belpomme D, Castronovo V, Bellahcène A: Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis. Elife. 2016 Oct 19; 2016 Oct 19. PMID: 27759563 Rebholz WN, Cash E, Zimmaro LA, Bayley-Veloso R, Phillips K, Siwik C, Chagpar AB, Dhabhar FS, Spiegel D, Bell BS, Sephton SE: Distress and quality of life in an ethnically diverse sample awaiting breast cancer surgery. J Health Psychol. 2016 Jul 26; 2016 Jul 26. PMID: 27466289 Rullo AF, Fitzgerald KJ, Muthusamy V, Liu M, Yuan C, Huang M, Kim M, Cho AE, Spiegel DA: Re-engineering the Immune Response to Metastatic Cancer: Antibody-Recruiting Small Molecules Targeting the Urokinase Receptor. Angew Chem Int Ed Engl. 2016 Mar 7; 2016 Feb 16. PMID: 26879524 Gautam S, Kim T, Lester E, Deep D, Spiegel DA: Wall teichoic acids prevent antibody binding to epitopes within the cell wall of Staphylococcus aureus. ACS Chem Biol. 2016 Jan 15; 2015 Nov 5. PMID: 26502318 Gray MA, Tao RN, DePorter SM, Spiegel DA, McNaughton BR: A Nanobody Activation Immunotherapeutic that Selectively Destroys HER2-Positive Breast Cancer Cells. Chembiochem. 2016 Jan; 2015 Dec 10. PMID: 26556305 Wang T, Streeter MD, Spiegel DA: Generation and characterization of antibodies against arginine-derived advanced glycation endproducts. Bioorg Med Chem Lett. 2015 Nov 1; 2015 Jun 11. PMID: 26117561 Draghici C, Wang T, Spiegel DA: Concise total synthesis of glucosepane. Science. 2015 Oct 16. PMID: 26472902 Gautam S, Kim T, Shoda T, Sen S, Deep D, Luthra R, Ferreira MT, Pinho MG, Spiegel DA: An Activity-Based Probe for Studying Crosslinking in Live Bacteria. Angew Chem Int Ed Engl. 2015 Sep 1; 2015 Jul 17. PMID: 26204841 Gautam S, Kim T, Spiegel DA: Chemical probes reveal an extraseptal mode of cross-linking in Staphylococcus aureus. J Am Chem Soc. 2015 Jun 17; 2015 Jun 2. PMID: 26035224 Dimitrievska S, Cai C, Weyers A, Balestrini JL, Lin T, Sundaram S, Hatachi G, Spiegel DA, Kyriakides TR, Miao J, Li G, Niklason LE, Linhardt RJ: Click-coated, heparinized, decellularized vascular grafts. Acta Biomater. 2015 Feb; 2014 Nov 20. PMID: 25463496 McEnaney PJ, Fitzgerald KJ, Zhang AX, Douglass EF Jr, Shan W, Balog A, Kolesnikova MD, Spiegel DA: Chemically synthesized molecules with the targeting and effector functions of antibodies. J Am Chem Soc. 2014 Dec 31; 2014 Dec 16. PMID: 25514603