Simons, Michael - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Simons is a graduate of Massachusetts Institute of Technology and Yale University School of Medicine. He completed his clinical training in internal medicine at the New England Medical Center in Boston and cardiology training at the Beth Israel Hospital in Boston. He completed a postdoctoral fellowships in molecular cardiology at National Heart Lung and Blood Institute in Bethesda and in vascular biology at MIT. In 1993 he joined faculty at Harvard Medical School as an Assistant Professor of Medicine and rose through the ranks to become an Associate Professor of Medicine, Director of the Morse Coronary Care Unit and Director of Angiogenesis Research Center. In 2001 he was recruited to Dartmouth as AG Huber Professor of Medicine and Chief of Cardiology, subsequently becoming Director of Dartmouth Cardiovascular Center. Dr. Simons’ research focuses on biology of arterial vasculature and spans basic, translational and clinical areas of investigations. He led the first trials of therapeutic angiogenesis in the USA and his basic research discoveries have played an important role in moving the field forward. Dr. Simons has an extensive track record of NIH funding including multiple R01s and he has served as a Principal Investigator of the NHLBI SCOR program in endothelial biology. Recently, he has been awarded a Leducq Transatlantic network grant to build and lead the ARTEMIS arteriogenesis network composed of investigators in USA, UK, Belgium and France. Dr. Simons also leads an NHLBI PPG program focused on arteriogenessi. He has published over 270 research papers and reviews and has been elected to a number of honorary societies including Association of American Physicians, American Society of Clinical Investigations and Association of University Cardiologists. He also a Fellow of the American Heart Association, American College of Cardiology and the American Society of Physiology. MD Yale University (1984) BS Massachusetts Institute of Technology (1980) Postdoctoral Fellow MIT, Boston, Massachusetts Fellow Beth Israel Hospital, Boston, Massachusetts Postdoctoral Fellow National Heart Lung and Blood Institute at National Institutes of Health, Bethesda, Maryland Resident New England Medical Center, Boston, Massachusetts

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Elfenbein A, Lanahan AA, Zhou TX, Yamasaki A, Tkachenko E, Matsuda M, Simons M. Syndecan 4 regulates endothelial FGFR1 signaling by directing macropinocytosis. Science Signaling 2012; 5:ra36. doi: 10.1126/scisignal.2002495 PMID: 22569333 Tirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A and Simons M. Endothelial NF?B -dependent regulation of arteriogenesis and branching. Circulation 2012; 126:2589-2600; PMID: 23091063 doi: 10.1161/CIRCULATIONAHA.112.119321 Chen P-Y*, Qin L*, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ, Anderson DG, Kotelianski V, Wang F, Tellides G, Simons M. FGF regulates TGFß signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Reports 2012; 2:1684-96; http://dx.doi.org/10.1016/j.celrep.2012.10.021. Deng Y, Atri D, Eichmann A, Simons M. Endothelial ERK signaling controls lymphatic fate specification. J. Clin Invest 2013; 123:1202:1215; doi: 10.1172/JCI63034; Lanahan AA*, Zhang X*, Fantin A, Zhuang ZW, Rivera-Molina F, Speichinger KR, Prahst C, Zhang J, Wang, Y, Davis GE, Toomre D, Ruhrberg C, Simons M.. The Neuropilin-1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis. Developmental Cell 2013; 25:156-168. doi:10.1016/j.devcell.2013.03.019; Moraes F, Paye J, Mc Gabhann F, Zhuang ZW, Zhang J, Lanahan AA, Simons M. Endothelial cell-dependent regulation of arteriogenesis. Circ Res 2013; 113:1076-86; doi: 10.1161/113.301340 (10 most read Circ Res papers of 2013) Chen P-Y, Qin L, Zhuang ZW, Tellides G, Lax I, Schlessinger J, Simons M. The docking protein FRS2a is a critical regulator of VEGF receptors signaling. Proc Natl Acad Sci USA 2014; 111:5514-19. doi: 10.1073/pnas.1404545111; Lanahan AA, Lech D, Dubrac A, Zhang J, Zhang ZW, Eichmann E, Simons M. PTP1b is a physiologic regulator of VEGF signaling in endothelial cells. Circulation 2014; 130:902-909 doi: 10.1161/CIRCULATIONAHA.114.009683. Chen PY, Qin L, Tellides G, Simons M. Fibroblast growth factor receptor 1 is a key regulator of TGFbeta signaling in the endothelium. Science Signaling 2014; 7:ra90