Simon, Matthew - Yale University - Biological & Biomedical Sciences

个人简介

Matt grew up in Ann Arbor, MI and received his Ph.D. in Chemistry from UC Berkeley. He commuted between Berkeley and UCSF, working with Kevan Shokat developing chemical methods to make synthetic chromatin substrates to study the biochemistry of epigenetics. He continued this work as a Helen Hay Whitney Foundation post doctoral fellow in Robert Kingston's laboratory at the Massachusetts General Hospital, where his interests expanded to include large non-coding RNAs and their impact on chromatin. He is part of the Chemical Biology Institute on Yale's West Campus, and The Department of Molecular Biophysics & Biochemistry, where his group's research focuses on developing new chemical and biochemical means of investigating long non-coding RNAs and their influence on chromatin biology. PhD University of California at Berkeley (2006) BA Tufts University (1999)

研究领域

Biochemistry; Biophysics; Chromatin; RNA, Untranslated

近期论文

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The site-specific installation of methyl-lysine analogs into recombinant histones. Simon, M.D., Chu, F., Racki, L.R., de la Cruz, C.C., Burlingame, A.L., Panning, B., Narlikar, G.J., and Shokat, K.M. The site-specific installation of methyl-lysine analogs into recombinant histones. Cell, 2007, 128, 1003-1012. The Genomic Binding-Sites of a Non- Coding RNA. Simon, M.D., Wang C.I., Kharchenko, P., West, J.A., Chapman, B.A., Alekseyenko, A.A., Borowsky, M.L., Kuroda, M.I., Kingston, R.E. The Genomic Binding-Sites of a Non- Coding RNA. Proc Natl Acad Sci, 2011, 108, 20497-20502. Duffy EE, Simon MD: Enriching s4 U-RNA Using Methane Thiosulfonate (MTS) Chemistry. Curr Protoc Chem Biol. 2016 Dec 7; 2016 Dec 7. PMID: 27925666 Rutenberg-Schoenberg M, Sexton AN, Simon MD: The Properties of Long Noncoding RNAs That Regulate Chromatin. Annu Rev Genomics Hum Genet. 2016 Aug 31; 2016 Apr 21. PMID: 27147088 Simon MD: Insight into lncRNA biology using hybridization capture analyses. Biochim Biophys Acta. 2016 Jan; 2015 Sep 14. PMID: 26381323 Sexton AN, Machyna M, Simon MD: Capture Hybridization Analysis of DNA Targets. Methods Mol Biol. 2016. PMID: 27659977 Fang R, Moss WN, Rutenberg-Schoenberg M, Simon MD: Probing Xist RNA Structure in Cells Using Targeted Structure-Seq. PLoS Genet. 2015 Dec; 2015 Dec 8. PMID: 26646615 Duffy EE, Rutenberg-Schoenberg M, Stark CD, Kitchen RR, Gerstein MB, Simon MD: Tracking Distinct RNA Populations Using Efficient and Reversible Covalent Chemistry. Mol Cell. 2015 Sep 3. PMID: 26340425 Simon MD, Pinter SF, Fang R, Sarma K, Rutenberg-Schoenberg M, Bowman SK, Kesner BA, Maier VK, Kingston RE, Lee JT: High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation. Nature. 2013 Dec 19; 2013 Oct 27. PMID: 24162848 Simon MD: Capture hybridization analysis of RNA targets (CHART). Curr Protoc Mol Biol. 2013. PMID: 23288463 Simon MD, Shokat KM: A method to site-specifically incorporate methyl-lysine analogues into recombinant proteins. Methods Enzymol. 2012. PMID: 22910202