Sigworth, Frederick J - Yale University - Biological & Biomedical Sciences

个人简介

Fred Sigworth studied applied physics at Caltech and was a graduate student at Yale, working in the neuroscience laboratory of Charles F. Stevens. He received the PhD in physiology from Yale in 1979 and was a postdoc in the laboratory of Erwin Neher in Göttingen, Germany where he was a co-developer of patch-clamp techniques for single-channel electrophysiology. He returned to Yale as a faculty member at Yale in 1984. His current research is in the structural biology of ion-channel proteins, making use of novel cryo-EM methods. "How do I see the scientific enterprise? An old book puts it this way: one generation commends God's works to another. It is a great privilege to unravel the workings of ion channels, and to pass on the excitement about these molecular machines to students, colleagues and anyone else who will listen!" PhD Yale University (1979) Research Associate Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. Post-Doctoral Fellow Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.

研究领域

Biomedical Engineering; Electrophysiology; Ion Channels; Microscopy, Electron; Physiology; Xenopus; Potassium Channels; Sodium Channels; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated; Voltage-Gated Sodium Channels

近期论文

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Principles of cryo-EM single-particle image processing Microscopy 65:57-67 Quantifying the local resolution of cryo-EM density maps Nature Methods 11:63-65 Statistical modeling and removal of lipid membrane projections for cryo-EM structure determination of reconstituted membrane proteins J. Struct. Biol. 194:49-60 Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy. Wang L and Sigworth FJ. Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy. Nature, 461(7261):292-5 Using cryo-EM to measure the dipole potential of a lipid membrane PNAS 103:18528-18533 Barmeyer C, Rahner C, Yang Y, Sigworth FJ, Binder HJ, Rajendran VM: Cloning and identification of tissue-specific expression of KCNN4 splice variants in rat colon. Am J Physiol Cell Physiol. 2010 Aug; 2010 May 5. PMID: 20445171