Shulman, Gerald I - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Shulman is the George R. Cowgill Professor of Medicine, Cellular & Molecular Physiology and Physiological Chemistry at Yale University, where he serves as Co-Director of the Yale Diabetes Research Center and Director of the Yale Mouse Metabolic Phenotyping Center. He is also an Investigator of the Howard Hughes Medical Institute. Dr. Shulman has pioneered the use of magnetic resonance spectroscopy to non-invasively examine intracellular glucose and fat metabolism in humans for the first time. Using this approach he has conducted ground breaking basic and clinical investigative studies on the cellular mechanisms of insulin resistance that have led to several paradigm shifts in our understanding of type 2 diabetes. Dr. Shulman has authored and co-authored over 400 peer-reviewed publications, and he has also trained more than 60 postdoctoral fellows and graduate students, many of whom now direct their own independent laboratories around the world. Dr. Shulman is a Master of the American College of Endocrinologists, Fellow of the American Association for the Advancement of Science and he has been elected to the American Society for Clinical Investigation, the Association of American Physicians, the National Academy of Medicine and the National Academy of Sciences. MD Wayne State University (1979) PhD Wayne State University (1979) BS University of Michigan, Ann Arbor, MI (1974) Fellow Massachusetts General Hospital/Harvard Medical School Resident Duke University Medical Center Board Certification AB of Internal Medicine, Internal Medicine (1982) Board Certification AB of Internal Medicine, Endocrinology & Metabolism (1985, recertified: 1985)

研究领域

Endocrine System Diseases; Chemicals and Drugs; Analytical, Diagnostic and Therapeutic Techniques and Equipment

近期论文

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Reversal of hypertriglyceridemia, fatty liver disease and insulin resistance by a liver-targeted mitochondrial uncoupler. Perry RJ, Kim T, Zhang XM, Lee HY, Pesta D, Popov VB, Zhang, D, Rahimi Y, Jurczak MJ, Cline GW, Spiegel DA, Shulman GI. Reversal of hypertriglyceridemia, fatty liver disease and insulin resistance by a liver-targeted mitochondrial uncoupler. Cell Metabolism. 2013;(18):740-48. PMID: 24206666. PMCID: 4104686. Direct assessment of hepatic mitochondrial oxidation and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy. Befroy DE, Perry RJ, Jain N, Dufour S, Cline GW, Trimmer J, Brosnan J, Rothman DL, Petersen KF, Shulman GI. Direct assessment of hepatic mitochondrial oxidation and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy. Nature Medicine 2013;1:(20):98-102. PMID: 24317120. PMCID: 3947269. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Perry RJ, Samuel VT, Petersen, KF, Shulman GI. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature. 2014;510(7503):84-91. PMID: 24899308. Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Perry RJ, Zhang XM, Zhang D, Kumashiro N, Camporez JP, Cline GW, Rothman DL, Shulman GI. Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Nature Medicine. 2014;20(7):759-63. PMID: 24929951. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Madiraju AK, Erion DM, Rahimi Y, Zhang XM, Braddock DT, Albright RA, Prigaro BJ, Wood JL, Bhanot S, MacDonald MJ, Jurczak, M, Camporez JP, Lee HY, Cline GW, Samuel VT, Kibbey RG, Shulman GI. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature. 2014;510:542-46. PMID:24847880. Role of ectopic fat in insulin resistance, dyslipidemia and cardiometabolic disease. Shulman, GI. Role of ectopic fat in insulin resistance, dyslipidemia and cardiometabolic disease. N Engl J Med. 2014;371(12)1131-1141. PMID: 25229917. Direct quantitation of muscle glycogen synthesis in normal man and noninsulin-dependent diabetics by 13C Nuclear Magnetic Resonance Spectroscopy. Shulman GI, Rothman DL, Jue T, Stein P, DeFronzo RA, Shulman RG. Direct quantitation of muscle glycogen synthesis in normal man and noninsulin-dependent diabetics by 13C Nuclear Magnetic Resonance Spectroscopy. N Eng J Med, 322:223-8, 1990. Quantitation of Hepatic Glycogenolysis and Gluconeogenesis in Humans with 13C NMR. Rothman DL, Magnusson I, Katz LD, Shulman RG, Shulman GI. Quantitation of Hepatic Glycogenolysis and Gluconeogenesis in Humans with 13C NMR. Science, 254:573-6, 1991. Effect of free fatty acids on IRS-1 associated phosphatidyl inositol 3-kinase activity. Dresner A, Laurent D, Marcucci M, Griffin ME, Dufour S, Cline GW, Slezak LA, Andersen DK, Hundal RS, Rothman DL, Petersen KF, Shulman GI. Effect of free fatty acids on IRS-1 associated phosphatidyl inositol 3-kinase activity. J Clin Invest, 103:253-9, Impaired glucose transport as a cause of decreased insulin stimulated muscle glycogen synthesis in type 2 diabetes. Cline G, Petersen KR, Krssak M, Shen J, Hundal RS, Trajanoski Z, Inzucchi S, Dresner A, Rothman DL, Shulman GI. Impaired glucose transport as a cause of decreased insulin stimulated muscle glycogen synthesis in type 2 diabetes. N Eng J Med, 341:240-6, 1999. Mitochondrial dysfunction in the elderly: Possible role in insulin resistance. Petersen K, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman D, DiPietro L, Cline G, Shulman GI. Mitochondrial dysfunction in the elderly: Possible role in insulin resistance. Science, 16(5622):1140-2, 2003. Impaired mitochondrial activity in the insulin resistant offspring of patients with type 2 diabetes. Petersen K, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin resistant offspring of patients with type 2 diabetes. N Eng J Med, 350:664-71, 2004. N-acylphosphatidylethanolamine, a gut-derived circulating factor induced by fat ingestion, inhibits food intake.