Shepherd, Gordon M - Yale University - Biological & Biomedical Sciences

个人简介

Gordon M. Shepherd grew up in Iowa, and received his B.S. at Iowa State College in 1955, M.D. at Harvard in 1959, and D.Phil. at Oxford in 1962. After postdoctoral training at NIH, MIT and the Karolinska Institute he joined the faculty at Yale Medical School, where he is Professor of Neuroscience. He introduced the olfactory system as a model for analyzing the properties of neurons and synapses in the brain and the formation of neural images of olfactory molecules. His research has contributed to properties of neuronal dendrites and spines, olfactory processing, and development of the new fields of computational neuroscience, brain microcircuits, neuroinformatics, and neurogastronomy. He has trained over 70 graduate students, postdoctoral fellows and visiting scientists, and published over 280 articles and reviews, with continuous grant support since 1966. His books include The Synaptic Organization of the Brain (5 ed.), Neurobiology (3 ed.), Handbook of Brain Microcircuits, and Neurogastronomy; in the history of neuroscience are Foundations of the Neuron Doctrine, Creating Modern Neuroscience, and Mosso's Circulation of Blood in the Human Brain. He has been chief editor of the Journal of Neurophysiology and Journal of Neuroscience. Visiting positions have included the University of Pennsylvania, College de France, Simon Fraser University, Santa Fe Institute, Ecole Normale Superieure, Institute Pasteur, and Oxford University. He served as a Deputy Provost of Yale University, received honorary degrees from the Universities of Copenhagen and Pavia, and is a member of the American Academy of Arts and Sciences and past president of the Association for Chemoreception Sciences and the Cajal Club. DPhil Oxford University (1962) MD Harvard University (1959) BS Iowa State College, Zoology (1955)

研究领域

Anatomy; Dendrites; Information Science; Interneurons; Nervous System; Neurons; Synapses; Pyramidal Cells; Dendritic Spines; Organisms; Phenomena and Processes

近期论文

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Twenty years of ModelDB and beyond: Building essential modeling tools for the future of neuroscience. McDougal RA, Morse TM, Carnevale T, Marenco L, Wang R, Migliore M, Miller PL, Shepherd GM, Hines ML. Twenty years of ModelDB and beyond: Building essential modeling tools for the future of neuroscience. J Comput Neurosci Sep 15. [Epub ahead of print] Glomerular and mitral-granule cell microcircuits coordinate temporal and spatial information processing in the olfactory bulb. Cavarretta F, Marasco A, Hines ML, Shepherd GM, Migliore M. 2016. Glomerular and mitral-granule cell microcircuits coordinate temporal and spatial information processing in the olfactory bulb. Front Comput Neurosci. Jul 14;10:67. doi: 10.3389/fncom.2016.00067. eCollection 2016. Role of ortho-retronasal olfaction in mammalian cortical evolution Rowe TB, Shepherd GM. 2016. Role of ortho-retronasal olfaction in mammalian cortical evolution. J Comp Neurol. Feb 15;524(3):471-95. doi: 10.1002/cne.23802. Epub 2015 Jun 11. Synaptic clusters function as odor operators in the olfactory bulb. Migliore M, Cavarretta F, Marasco A, Tulumello E, Hines ML, Shepherd GM. Synaptic clusters function as odor operators in the olfactory bulb. 2015. Proc Natl Acad Sci U S A. Jul 7;112(27):8499-504. doi: 10.1073/pnas.1502513112. Epub Jun 22. Comparison of glomerular activity patterns by fMRI and wide-field calcium imaging: Implications for principles underlying odor mapping. Sanganahalli BG, Rebello MR, Herman P, Papademetris X, Shepherd GM, Verhagen JV, Hyder F. 2016. Comparison of glomerular activity patterns by fMRI and wide-field calcium imaging: Implications for principles underlying odor mapping. Neuroimage. Feb 1;126:208-18. doi: 10.1016/j.neuroimage.2015.11.048. Epub 2015 Nov 26. Sparse coding and lateral inhibition arising from balanced and unbalanced dendrodendritic excitation and inhibition Sparse coding and lateral inhibition arising from balanced and unbalanced dendrodendritic excitation and inhibition. Yu Y, Migliore M, Hines ML, Shepherd GM. J Neurosci. 2014 Oct 8;34(41):13701-13. doi: 10.1523/JNEUROSCI.1834-14.2014. Perception of odors linked to precise timing in the olfactory system. Rebello MR, McTavish TS, Willhite DC, Short SM, Shepherd GM, Verhagen JV. 2014. Perception of odors linked to precise timing in the olfactory system. PLoS Biology 12: e1002021. doi: 10.1371/journal.pbio.1002021. eCollection 2014 Dec Distributed organization of a brain microcircuit analyzed by three-dimensional modeling: the olfactory bulb Distributed organization of a brain microcircuit analyzed by three-dimensional modeling: the olfactory bulb. Migliore M, Cavarretta F, Hines ML, Shepherd GM. Front Comput Neurosci. 2014 Apr 29;8:50. doi: 10.3389/fncom.2014.00050. eCollection 2014. Symposium overview and historical perspective: dendrodendritic synapses: past, present, and future. Shepherd GM. Symposium overview and historical perspective: dendrodendritic synapses: past, present, and future. Ann N Y Acad Sci. 2009 Jul;1170:215-23. PMID: 19686140 [PubMed - in process] The NIF LinkOut broker: a web resource to facilitate federated data integration using NCBI identifiers. Marenco L, Ascoli GA, Martone ME, Shepherd GM, Miller PL. The NIF LinkOut broker: a web resource to facilitate federated data integration using NCBI identifiers. Neuroinformatics. 2008 Sep;6(3):219-27. Epub 2008 Oct 31. PMID: 18975149 [PubMed - indexed for MEDLINE] Learning mechanism for column formation in the olfactory bulb Migliore M, Inzirillo C, Shepherd GM. Learning mechanism for column formation in the olfactory bulb. Front Integr Neurosci. 2007;1:12. Epub 2007 Dec 30. PMID: 18958240 [PubMed - in process] Odor-evoked oxygen consumption by action potential and synaptic transmission in the olfactory bulb Lecoq J, Tiret P, Najac M, Shepherd GM, Greer CA, Charpak S. 2009. Odor-evoked oxygen consumption by action potential and synaptic transmission in the olfactory bulb. J Neurosci. 29:1424-33. An energy budget for the olfactory glomerulus.