Sessa, William C - Yale University - Biological & Biomedical Sciences

个人简介

PhD New York Medical College (1989) Post-doctoral fellow Pharmacology, The University of Virginia Health Sciences Center Post-doctoral fellow/Senior Scientist The William Harvey Research Institute

研究领域

Cardiovascular Diseases; Cell Membrane Permeability; Circulatory and Respiratory Physiological Phenomena; Neoplasms; Chemicals and Drugs

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Nogo-B receptor stabilizes Nieman Pick Type C2 protein and regulate intracellular cholesterol trafficking. Harrison, K.D., Miao, R.Q., Fernandez-Hernando, C., Suarez, Y., Davalos, A. and Sessa, W.C. Nogo-B receptor stabilizes Nieman Pick Type C2 protein and regulate intracellular cholesterol trafficking. Cell Metabolism, 10: 208-218 (2009). he Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. Schleicher, M., Yu, J., Murata, T., Derakhshan, B., Atochin, D., Qian, L., Kashiwagi, S., Di Lorenzo, A., Harrison, K.D., Huang, P.L and Sessa, W.C. The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. Science Signaling, 2(82):ra41 (2009). Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Suárez Y, Fernández-Hernando C, Yu J, Gerber SA, Harrison KD, Pober JS, Iruela-Arispe ML, Merkenschlager M and Sessa WC. Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A. 16;105(37):14082-7 (2008). Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease Fernandez-Hernando, C., Ackah, E., Yu., J., Suarez, Y., Murata, T., Iwakiri, Y., Prendergast, J., Miao, R.Q., Birnbaum, M.J. and Sessa, W.C. Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metabolism (6):446-57 (2007). Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase Fernandez-Hernando, C., et al. (2006). Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. J. Cell Biol. 174(3):369-77. Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells Miao, R.Q., et al. (2006). Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. Proc. Natl. Acad. Sci. (USA) 103(29):10997-1002. A new role for Nogo as a regulator of vascular remodeling. Acevedo L, Yu J, Erdjument-Bromage H, Miao RQ, Kim JE, Fulton D, Tempst P,. Strittmatter SM and Sessa WC. (2004). "A new role for Nogo as a regulator of vascular remodeling." Nat Med 10(4): 382-8. Nakamura T, Fujiwara Y, Yamada R, Fujii W, Hamabata T, Lee MY, Maeda S, Aritake K, Roers A, Sessa WC, Nakamura M, Urade Y, Murata T: Mast cell-derived prostaglandin D2 attenuates anaphylactic reactions in mice. J Allergy Clin Immunol. 2017 Apr 22; 2017 Apr 22. PMID: 28457595 Kuo A, Lee MY, Sessa WC: Lipid Droplet Biogenesis and Function in the Endothelium. Circ Res. 2017 Apr 14; 2017 Jan 24. PMID: 28119423 Luciano AK, Santana JM, Velazquez H, Sessa WC: Akt1 Controls the Timing and Amplitude of Vascular Circadian Gene Expression. J Biol Rhythms. 2017 Apr 1; 2017 Apr 1. PMID: 28452287 Kraehling JR, Sessa WC: Contemporary Approaches to Modulating the Nitric Oxide-cGMP Pathway in Cardiovascular Disease. Circ Res. 2017 Mar 31. PMID: 28360348 Ola R, Dubrac A, Han J, Zhang F, Fang JS, Larrivée B, Lee M, Urarte AA, Kraehling JR, Genet G, Hirschi KK, Sessa WC, Canals FV, Graupera M, Yan M, Young LH, Oh PS, Eichmann A: PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia. Nat Commun. 2016 Nov 29; 2016 Nov 29. PMID: 27897192 Kraehling JR, Chidlow JH, Rajagopal C, Sugiyama MG, Fowler JW, Lee MY, Zhang X, Ramírez CM, Park EJ, Tao B, Chen K, Kuruvilla L, Larriveé B, Folta-Stogniew E, Ola R, Rotllan N, Zhou W, Nagle MW, Herz J, Williams KJ, Eichmann A, Lee WL, Fernández-Hernando C, Sessa WC: Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells. Nat Commun. 2016 Nov 21; 2016 Nov 21. PMID: 27869117 Grabińska KA, Park EJ, Sessa WC: cis-Prenyltransferase: New Insights into Protein Glycosylation, Rubber Synthesis, and Human Diseases. J Biol Chem. 2016 Aug 26; 2016 Jul 11. PMID: 27402831 Ulrich V, Rotllan N, Araldi E, Luciano A, Skroblin P, Abonnenc M, Perrotta P, Yin X, Bauer A, Leslie KL, Zhang P, Aryal B, Montgomery RL, Thum T, Martin K, Suarez Y, Mayr M, Fernandez-Hernando C, Sessa WC: Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice. EMBO Mol Med. 2016 Jun; 2016 Jun 1. PMID: 27137489 Liu D, Lei L, Desir M, Huang Y, Cleman J, Jiang W, Fernandez-Hernando C, Di Lorenzo A, Sessa WC, Giordano FJ: Smooth Muscle Hypoxia-Inducible Factor 1α Links Intravascular Pressure and Atherosclerosis--Brief Report. Arterioscler Thromb Vasc Biol. 2016 Mar; 2016 Jan 21. PMID: 26800562 Marin EP, Jozsef L, Di Lorenzo A, Held KF, Luciano AK, Melendez J, Milstone LM, Velazquez H, Sessa WC: The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics. Arterioscler Thromb Vasc Biol. 2016 Feb; 2015 Dec 29. PMID: 26715683 Park EJ, Grabińska KA, Guan Z, Sessa WC: NgBR is essential for endothelial cell glycosylation and vascular development. EMBO Rep. 2016 Feb; 2016 Jan 11. PMID: 26755743