Schwartz, Martin A - Yale University - Biomedical Engineering

个人简介

Martin Schwartz earned a BA in chemistry from New College in Sarasota FL and a PhD in physical chemistry from Stanford, where he worked in Harden McConnell’s lab on biophysics of phospholipid membranes.He then did postdoctoral research in biology at MIT in the laboratory of Richard Hynes where he studied interactions of fibronectin with cells and other proteins. He was on the faculty at Harvard Medical School, Scripps Research Institute and the University of Virginia prior to moving to Yale in 2011. Starting in the 1980’s, his lab was among the first to report that integrin mediated adhesion could regulate signaling pathways in cells;that integrin-mediated adhesion promotes cell survival, that integrins synergize with growth factor receptors to activate growth signaling pathways and that integrins regulate Rho family GTPases. His lab has also elucidated mechanotransduction pathways by which endothelial cells respond to fluid shear stress to activate inflammatory pathways linked to atherosclerosis. His current research program combines studies using biophysical, cellular and animal approaches to important questions about integrin signaling, mechanotransduction and disease in the vascular system. PhD Stanford University (1979) BA New College of the University South Florida (1975) Postdoctoral fellow MIT

研究领域

Integrin signaling and mechanotransduction in the vasculature with emphasis on topics that are relevant to human disease. My lab works on fundamental biophysical mechanisms of mechanotransduction, how the resultant pathways govern cell function, and how these effects regulate development and disease in animal models.

近期论文

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Baeyens N., Larrivée B, Ola R., Hayward-Piatkowskyi B., Dubrac A., Huang B., Ross TD, Coon BG, Min E, Tsarfati M, Tong H, Eichmann A and Schwartz MA. Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia (HHT). 2016 J. Cell Biol. 214:807-16. Yun S, Budatha M, Dahlman JE, Coon BG, Cameron RT, Langer R, Anderson DG, Baillie G, Schwartz MA. Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling. Nat. Cell Biol. 2016 18:1043-53. Conway DE, Breckenridge MT, Hinde E, Gratton E, Chen CS, Schwartz MA. Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1. Curr Biol. 2013 Jun 3, 23:1024-30 Hoffman, B.D., Grashoff, C. and Schwartz, M.A. Dynamic molecular processes mediate cellular mechanotransduction. Nature. 2011, 475:316-323. Grashoff C., Hoffman BD., Brenner MD., Zhou R., Parsons M., Yang MT., McLean MA., Sligar SG., Chen CS., Ha T. and Schwartz, MA.. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature, 2010,466:263-6. Orr, A.W., Stockton, R., Simmers,M.B., Sanders, J.M., Sarembock, I.J., Blackman, B.R., Schwartz, M.A. Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis. J Cell Biol. 2007, 176:719-727.