Schlieker, Christian - Yale University - Biological & Biomedical Sciences

个人简介

Research in the Schlieker laboratory focuses on furthering our understanding of nuclear protein quality control, transport of viral particles across the nuclear membranes, and the relationship between nuclear membrane proteins and human disease. PhD University of Heidelberg (2004)

研究领域

Biochemistry; Biophysics; Cell Biology; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

近期论文

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Torsin ATPases: structural insights and functional perspectives. Current Opinion in Cell Biology 40:1-7. Laudermilch, E, Schlieker, C. Current Opinion in Cell Biology (2016); 40:1-7. Torsins: not your typical AAA+ ATPases. Rose AE, Brown RS, Schlieker C. Crit Rev Biochem Mol Biol. (2015); 50(6):532-49. The Torsin Activator LULL1 Is Required for Efficient Growth of Herpes Simplex Virus 1. Turner EM, Brown RS, Laudermilch E, Tsai PL, Schlieker C. J Virol. (2015); 89(16):8444-52. The mechanism of Torsin ATPase activation Brown RS, Zhao C, Chase AR, Wang J, Schlieker C. Proc Natl Acad Sci U S A. (2014); 111(45):E4822-31 Regulation of Torsin ATPases by LAP1 and LULL1. Zhao C, Brown RS, Chase AR, Eisele MR, Schlieker C. Proc Natl Acad Sci U S A (2013); 110(17):E1545-54. Alternative nuclear transport for cellular protein quality control. Rose A, Schlieker C. Trends Cell Biol. (2012); 22(10):509-14. Arresting a Torsin ATPase reshapes the endoplasmic reticulum. Rose AE, Zhao C, Turner EM, Steyer AM, Schlieker C. J Biol Chem. 289 (2014); (1):552-64. The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations. Tsai PL, Zhao C, Turner E, Schlieker C: The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations. Elife. 2016 Jun 23; 2016 Jun 23. Laudermilch E, Tsai PL, Graham M, Turner E, Zhao C, Schlieker C: Dissecting Torsin/cofactor function at the nuclear envelope: a genetic study. Mol Biol Cell. 2016 Dec 15; 2016 Oct 26. PMID: 27798237 Turner EM, Schlieker C: Pelger-Huët anomaly and Greenberg skeletal dysplasia: LBR-associated diseases of cholesterol metabolism. Rare Dis. 2016; 2016 Sep 27. PMID: 27830109 Tsai PL, Zhao C, Turner E, Schlieker C: The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations. Elife. 2016 Jun 23; 2016 Jun 23. PMID: 27336722 Laudermilch E, Schlieker C: Torsin ATPases: structural insights and functional perspectives. Curr Opin Cell Biol. 2016 Jun; 2016 Jan 21. PMID: 26803745 Zhao C, Brown RS, Tang CH, Hu CC, Schlieker C: Site-specific Proteolysis Mobilizes TorsinA from the Membrane of the Endoplasmic Reticulum (ER) in Response to ER Stress and B Cell Stimulation. J Biol Chem. 2016 Apr 29; 2016 Mar 7. PMID: 26953341 Speltz EB, Brown RS, Hajare HS, Schlieker C, Regan L: A designed repeat protein as an affinity capture reagent. Biochem Soc Trans. 2015 Oct. PMID: 26517897 Turner EM, Brown RS, Laudermilch E, Tsai PL, Schlieker C: The Torsin Activator LULL1 Is Required for Efficient Growth of Herpes Simplex Virus 1. J Virol. 2015 Aug; 2015 Jun 3. PMID: 26041288 Rose AE, Brown RS, Schlieker C: Torsins: not your typical AAA+ ATPases. Crit Rev Biochem Mol Biol. 2015; 2015 Oct 13. PMID: 26592310 Brown RS, Zhao C, Chase AR, Wang J, Schlieker C: The mechanism of Torsin ATPase activation. Proc Natl Acad Sci U S A. 2014 Nov 11; 2014 Oct 28. PMID: 25352667