Schlessinger, Joseph - Yale University - Biological & Biomedical Sciences

个人简介

PhD Weizmann Institute of Science, Isarel (1974) MSc Hebrew University of Jerusalem (1969) BS Hebrew University of Jerusalem (1968)

研究领域

Pharmacology; Phosphorylation; Protein Kinases; Signal Transduction; Crystallography, X-Ray; Receptor Protein-Tyrosine Kinases; Cell Proliferation; Drug Discovery

近期论文

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Structural analysis of the mechanism of phosphorylation of a critical autoregulatory tyrosine residue in FGFR1 kinase domain. Kobashigawa Y, Amano S, Yokogawa M, Kumeta H, Morioka H, Inouye M, Schlessinger J, Inagaki F.Structural analysis of the mechanism of phosphorylation of a critical autoregulatory tyrosine residue in FGFR1 kinase domain. Genes Cells. 2015 Aug 24. doi: 10.1111/gtc.12277. [Epub ahead of print] Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas. Krauthammer M, Kong Y, Bacchiocchi A, Evans P, Pornputtapong N, Wu C, McCusker JP, Ma S, Cheng E, Straub R, Serin M, Bosenberg M, Ariyan S, Narayan D, Sznol M, Kluger HM, Mane S, Schlessinger J, Lifton RP, Halaban R. Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas. Nat Genet. 2015 Sep;47(9):996-1002. doi: 10.1038/ng.3361. Epub 2015 Jul 27. FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Perry RJ, Lee S, Ma L, Zhang D, Schlessinger J, Shulman GI. Nat Commun. 2015 Apr 28;6:6980. doi: 10.1038/ncomms7980. Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK. Murray PB, Lax I, Reshetnyak A, Ligon GF, Lillquist JS, Natoli EJ Jr, Shi X, Folta-Stogniew E, Gunel M, Alvarado D, Schlessinger J. Sci Signal. 2015 Jan 20;8(360):ra6. doi: 10.1126/scisignal.2005916. Whole-exome sequencing characterizes the landscape of somatic mutations and copy number alterations in adrenocortical carcinoma. Juhlin CC, Goh G, Healy JM, Fonseca AL, Scholl UI, Stenman A, Kunstman JW, Brown TC, Overton JD, Mane SM, Nelson-Williams C, Bäckdahl M, Suttorp AC, Haase M, Choi M, Schlessinger J, Rimm DL, Höög A, Prasad ML, Korah R, Larsson C, Lifton RP, Carling T. J Clin Endocrinol Metab. 2015 Mar;100(3):E493-502. doi: 10.1210/jc.2014-3282. Epub 2014 Dec 9. Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities. Lew ED, Oh J, Burrola PG, Lax I, Zagórska A, Través PG, Schlessinger J, Lemke G. Elife. 2014 Sep 29;3. doi: 10.7554/eLife.03385. The docking protein FRS2α is a critical regulator of VEGF receptors signaling. Chen PY, Qin L, Zhuang ZW, Tellides G, Lax I, Schlessinger J, Simons M. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5514-9. doi: 10.1073/pnas.1404545111. Epub 2014 Apr 2. Receptor tyrosine kinases: legacy of the first two decades. Schlessinger J. Cold Spring Harb Perspect Biol. 2014 Mar 1;6(3). pii: a008912. doi: 10.1101/cshperspect.a008912. Review. Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers. Opatowsky Y, Lax I, Tomé F, Bleichert F, Unger VM, Schlessinger J. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1772-7. doi: 10.1073/pnas.1323254111. Epub 2014 Jan 21. Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region. Reshetnyak AV, Nelson B, Shi X, Boggon TJ, Pavlenco A, Mandel-Bausch EM, Tome F, Suzuki Y, Sidhu SS, Lax I, Schlessinger J. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17832-7. doi: 10.1073/pnas.1317118110. Epub 2013 Oct 14. Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma. Zhao S, Choi M, Overton JD, Bellone S, Roque DM, Cocco E, Guzzo F, English DP, Varughese J, Gasparrini S, Bortolomai I, Buza N, Hui P, Abu-Khalaf M, Ravaggi A, Bignotti E, Bandiera E, Romani C, Todeschini P, Tassi R, Zanotti L, Carrara L, Pecorelli S, Silasi DA, Ratner E, Azodi M, Schwartz PE, Rutherford TJ, Stiegler AL, Mane S, Boggon TJ, Schlessinger J, Lifton RP, Santin AD. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2916-21. doi: 10.1073/pnas.1222577110. Epub 2013 Jan 28. RAC1P29S is a spontaneously activating cancer-associated GTPase. Davis MJ, Ha BH, Holman EC, Halaban R, Schlessinger J, Boggon TJ. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):912-7. doi: 10.1073/pnas.1220895110. Epub 2013 Jan 2. Cell signaling by receptor tyrosine kinases.