Schepartz, Alanna - Yale University - Biological & Biomedical Sciences

个人简介

Alanna Schepartz was born in New York City on January 9, 1962 and was graduated from Forest Hills High School in 1978. From 1978-1982 she attended the State University of New York@ Albany where she majored in Chemistry and carried out undergraduate research on organic electrochemistry with Shelton Bank. In 1982 Alanna moved back to NYC to attend graduate school at Columbia University and receivedher doctorate in 1987 for research on the mechanism of catalysis by the enzymecarboxypeptidase A. Alanna then traveled to the CaliforniaInstitute of Technology, where she developed chemical methods to explore the topology ofeukaryotic ribosomes and the interactions of ribosomal RNAs with antibiotics. In 1988 shejoined the Chemistry Department at Yale University where she is now the Milton Harris ’29 Ph.D. Professor of Chemistry and Professor of Molecular, Cellular, and Developmental Biology. Research in the Schepartz laboratory is focused on the design and synthesis of new classes of molecules that manipulate, monitor, or mimic protein–protein and protein–DNA interactions inside the cell. Current topics include the use of miniature proteins to identify thefunctional role of discrete protein-protein interactions and rewire cellular circuits, the use of cell permeable fluorescent dyes to image misfolded proteins or protein interactions in live cells, and the design of protein-like assemblies of ß-peptides that are entirely devoid of alpha aminoacids. The ß-peptide assemblies reported by the Schepartz laboratory represent thevery first example of a synthetic molecule with protein-like structure and stability. PhD Columbia University, Organic Chemistry (1987) BS State University of New York-Albany, Chemistry (1982) NIH Postdoctoral Fellow Caltech

研究领域

Biochemistry; Biology; Chemistry; Cell Biology; Diseases; Chemicals and Drugs; Health Care

近期论文

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Visualizing tyrosine kinase activity with bipartite tetracysteine display. Visualizing tyrosine kinase activity with bipartite tetracysteine display. S. Ray-Saha & A. Schepartz, ChemBioChem. 2010, 11, 2089-2091 Direct visualization of protein association in living cells with complex-edited electron microscopy Direct visualization of protein association in living cells with complex-edited electron microscopy. R.J. Dexter & A. Schepartz, Angew. Chem. 2010, 49, 7952-7954. Selective recognition of protein tetraserine motifs with a cell-permeable, pro-fluorescent bis-boronic acid Selective recognition of protein tetraserine motifs with a cell-permeable, pro-fluorescent bis-boronic acid. T.L. Halo, J. Appelbaum, E.M. Hobert, D.M. Balkin, & A. Schepartz, J. Am. Chem. Soc. 2009, 131, 438-439 Toward ß-amino acid proteins: design, synthesis, and characterization of a fifteen kilodalton ß-peptide tetramer. Toward ß-amino acid proteins: design, synthesis, and characterization of a fifteen kilodalton ß-peptide tetramer. E.J. Petersson & A. Schepartz, J. Am. Chem. Soc. 2008, 130, 821-823 Intrinsically cell-permeable miniature proteins based on a minimal cationic PPll motif. Intrinsically cell-permeable miniature proteins based on a minimal cationic PPll motif. D.S. Daniels & A. Schepartz, J. Am. Chem. Soc. 2007, 129, 14578-14579 Surveying polypeptide and protein domain conformation and association with FIAsH and ReAsH. Luedtke, N.W., Dexter, R.J., Fried, D.B., and Schepartz, A. (2007). Surveying polypeptide and protein domain conformation and association with FIAsH and ReAsH. Nat. Chem. Biol. 3: 779-78 Bottanelli F, Kilian N, Ernst AM, Rivera-Molina F, Schroeder LK, Kromann EB, Lessard MD, Erdmann RS, Schepartz A, Baddeley D, Bewersdorf J, Toomre D, Rothman JE: A novel physiological role for ARF1 in the formation of bi-directional tubules from the Golgi. Mol Biol Cell. 2017 Apr 20; 2017 Apr 20. PMID: 28428254 Wang PS, Schepartz A: β-Peptide bundles: Design. Build. Analyze. Biosynthesize. Chem Commun (Camb). 2016 Jun 14; 2016 May 5. PMID: 27146019 Melo Czekster C, Robertson WE, Walker AS, Söll D, Schepartz A: In Vivo Biosynthesis of a β-Amino Acid-Containing Protein. J Am Chem Soc. 2016 Apr 27; 2016 Apr 18. PMID: 27086674 Pelletier G, Zwicker A, Allen CL, Schepartz A, Miller SJ: Aqueous Glycosylation of Unprotected Sucrose Employing Glycosyl Fluorides in the Presence of Calcium Ion and Trimethylamine. J Am Chem Soc. 2016 Mar 9; 2016 Mar 1. PMID: 26859619 Bottanelli F, Kromann EB, Allgeyer ES, Erdmann RS, Wood Baguley S, Sirinakis G, Schepartz A, Baddeley D, Toomre DK, Rothman JE, Bewersdorf J: Two-colour live-cell nanoscale imaging of intracellular targets. Nat Commun. 2016 Mar 4; 2016 Mar 4. PMID: 26940217 Li M, Tao Y, Shu Y, LaRochelle JR, Steinauer A, Thompson D, Schepartz A, Chen ZY, Liu DR: Discovery and characterization of a peptide that enhances endosomal escape of delivered proteins in vitro and in vivo. J Am Chem Soc. 2015 Nov 11; 2015 Oct 30. PMID: 26465072 Melicher MS, Walker AS, Shen J, Miller SJ, Schepartz A: Improved Carbohydrate Recognition in Water with an Electrostatically Enhanced β-Peptide Bundle. Org Lett. 2015 Oct 2. PMID: 26376076 Doerner A, Scheck R, Schepartz A: Growth Factor Identity Is Encoded by Discrete Coiled-Coil Rotamers in the EGFR Juxtamembrane Region. Chem Biol. 2015 Jun 18. PMID: 26091170 Lowder MA, Doerner AE, Schepartz A: Structural Differences between Wild-Type and Double Mutant EGFR Modulated by Third-Generation Kinase Inhibitors. J Am Chem Soc. 2015 May 27; 2015 May 14. PMID: 25973741 LaRochelle JR, Cobb GB, Steinauer A, Rhoades E, Schepartz A: Fluorescence correlation spectroscopy reveals highly efficient cytosolic delivery of certain penta-arg proteins and stapled peptides. J Am Chem Soc. 2015 Feb 25; 2015 Feb 13. PMID: 25679876 Miller JP, Melicher MS, Schepartz A: Positive allostery in metal ion binding by a cooperatively folded β-peptide bundle. J Am Chem Soc. 2014 Oct 22; 2014 Oct 7. PMID: 25290247 Sinclair JK, Schepartz A: Influence of macrocyclization on allosteric, juxtamembrane-derived, stapled peptide inhibitors of the epidermal growth factor receptor (EGFR). Org Lett. 2014 Sep 19; 2014 Sep 10. PMID: 25207804 Erdmann RS, Takakura H, Thompson AD, Rivera-Molina F, Allgeyer ES, Bewersdorf J, Toomre D, Schepartz A: Super-resolution imaging of the Golgi in live cells with a bioorthogonal ceramide probe. Angew Chem Int Ed Engl. 2014 Sep 15; 2014 Jul 31. PMID: 25081303 Sinclair JK, Denton EV, Schepartz A: Inhibiting epidermal growth factor receptor at a distance. J Am Chem Soc. 2014 Aug 13; 2014 Jul 30. PMID: 25075632