Santos-Sacchi, Joseph - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Joseph Santos-Sacchi, Professor, works on understanding how outer hair cells (OHC) help us hear so well. His lab focuses on electrophysiological assessment of hair cell function and molecular manipulations of the proteins that are important for hearing. MPhil Columbia University, Audiology (1978) PhD Columbia University (1978) BA Columbia College, Psychology (1973)

研究领域

Hair Cells, Auditory; Ear, Inner; Neurosciences; Otolaryngology; Physiology

近期论文

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Determination of cell capacitance using the exact empirical solution of partial differential Y/partial differential Cm and its phase angle Santos-Sacchi J. Determination of cell capacitance using the exact empirical solution of partial differential Y/partial differential Cm and its phase angle. Biophys J, 87:714-27, 2004. Control of mammalian cochlear amplification by chloride anions. Santos-Sacchi J, Song L, Zheng J, Nuttall AL. Control of mammalian cochlear amplification by chloride anions. J Neurosci, 26(15):3992-8, 2006. En block C-terminal charge cluster reversals in prestin (SLC26A5): effects on voltage-dependent electromechanical activity. Bai JP, Navaratnam D, Samaranayake H, Santos-Sacchi J. En block C-terminal charge cluster reversals in prestin (SLC26A5): effects on voltage-dependent electromechanical activity. Neurosci Lett, 404(3):270-5, 2006. Developmental expression of the outer hair cell motor prestin in the mouse Abe T, Kakehata S, Kitani R, Maruya S, Navaratnam D, Santos-Sacchi J, Shinkawa H. Developmental expression of the outer hair cell motor prestin in the mouse. J Membr Biol, 215(1):49-56, 2007. Anion control of voltage sensing by the motor protein prestin in outer hair cells Rybalchenko V and Santos-Sacchi J. Anion control of voltage sensing by the motor protein prestin in outer hair cells. Biophysical J, 95(9):4439-47, 2008. Fast electromechanical amplification in the lateral membrane of the outer hair cell Santos-Sacchi J, Navarrete E, Song L. Fast electromechanical amplification in the lateral membrane of the outer hair cell. Biophysical J, 96(2):739-47, 2009. Prestin’s anion transport and voltage sensing capabilities are independent Bai J-P, Surguchev A, Montoya S, Aronson PS, Santos-Sacchi J, Navaratnam D. Prestin’s anion transport and voltage sensing capabilities are independent. Biophysical J, 96(8):3179-86, 2009. Bai JP, Moeini-Naghani I, Zhong S, Li FY, Bian S, Sigworth FJ, Santos-Sacchi J, Navaratnam D: Current carried by the Slc26 family member prestin does not flow through the transporter pathway. Sci Rep. 2017 Apr 19; 2017 Apr 19. PMID: 28422190 Tan WJT, Song L, Graham M, Schettino A, Navaratnam D, Yarbrough WG, Santos-Sacchi J, Ivanova AV: Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear. Antioxid Redox Signal. 2017 Mar 9; 2017 Mar 9. PMID: 28135838 Lv C, Stewart WJ, Akanyeti O, Frederick C, Zhu J, Santos-Sacchi J, Sheets L, Liao JC, Zenisek D: Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels. Cell Rep. 2016 Jun 21; 2016 Jun 9. PMID: 27292637 Santos-Sacchi J, Song L: Chloride Anions Regulate Kinetics but Not Voltage-Sensor Qmax of the Solute Carrier SLC26a5. Biophys J. 2016 Jun 7. PMID: 27276272 Song L, Santos-Sacchi J: A Walkthrough of Nonlinear Capacitance Measurement of Outer Hair Cells. Methods Mol Biol. 2016. PMID: 27259945 McKay SE, Yan W, Nouws J, Thormann MJ, Raimundo N, Khan A, Santos-Sacchi J, Song L, Shadel GS: Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness. Am J Pathol. 2015 Dec; 2015 Nov 6. PMID: 26552864 Song L, Santos-Sacchi J: An electrical inspection of the subsurface cisternae of the outer hair cell. Biophys J. 2015 Feb 3. PMID: 25650924 Zhang Y, Moeini-Naghani I, Bai J, Santos-Sacchi J, Navaratnam DS: Tyrosine motifs are required for prestin basolateral membrane targeting. Biol Open. 2015 Jan 16; 2015 Jan 16. PMID: 25596279 Santos-Sacchi J, Song L: Chloride-driven electromechanical phase lags at acoustic frequencies are generated by SLC26a5, the outer hair cell motor protein. Biophys J. 2014 Jul 1. PMID: 24988347 Zhong S, Navaratnam D, Santos-Sacchi J: A genetically-encoded YFP sensor with enhanced chloride sensitivity, photostability and reduced ph interference demonstrates augmented transmembrane chloride movement by gerbil prestin (SLC26a5). PLoS One. 2014; 2014 Jun 5. PMID: 24901231 Okunade O, Santos-Sacchi J: IR laser-induced perturbations of the voltage-dependent solute carrier protein SLC26a5. Biophys J. 2013 Oct 15. PMID: 24138858