Saltzman, W. Mark - Yale University - Department of Chemical & Environmental Engineering

个人简介

Ph.D., Harvard/MIT Division of Health Science and Technology S.M., Massachusetts Institute of Technology B.S., Iowa State University

研究领域

Saltzman's research is motivated by the desire to create safer and more effective medical and surgical therapy. He focuses on tissue engineering and on creating better methods for drug delivery. His group has developed technology based on the use of bio-compatible polymeric materials for the controlled delivery of drugs, proteins, and genes. They have also developed new polymeric materials that influence the growth and assembly of tissues. However, even better than treating disease is to prevent disease from occurring in the first place. Saltzman's intent, therefore, is to develop the most economical, transportable, and accessible methods for disease prevention. Saltzman is also committed to training a new generation of chemical and biomedical engineers. He believes in providing a stimulating and collaborative environment that promotes the free exchange of ideas and encourages creative blending of technology and modern biological science.

近期论文

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Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, and Slack FJ. MicroRNA silencing for cancer therapy targeted to the tumor microenvironment, Nature 518:107-110 (2015). PMCID: PMC4367962. Cheng CJ, Tietjen GT, Saucier-Sawyer JK, and Saltzman WM. A holistic approach to targeting disease with polymer nanoparticles, Nature Reviews Drug Discovery 14:239-247 (2015). PMCID: PMC4451203. McNeer NA, Anandalingam K, Quijano E, Fields RJ, Caputo C, Glazer PM, Saltzman WM, and Egan ME. In vivo and in vitro correction of F508del CFTR using nanoparticles with triplex-forming PNAs in airway epithelia. Nature Communications 6:6952 (2015). PMCID: PMC4480796. Deng Y, Ediriwickrema A, Yang F, Lewis J, Girardi M, and Saltzman WM. A sunblock based on bioadhesive nanoparticles, Nature Materials 14:1278-85 (2015). PCMID: PMC4654636. Gavrilov K, Seo YE, Tietjen GT, Cui J, Cheng CJ, and Saltzman WM. Enhancement in siRNA potency by optimization outside of target sequence selection, Proceedings of the National Academy of Sciences, 112: E6597-E6605 (2015). PCMID: PMC4672813 Gaudin A, Song E, King AR, Saucier-Sawyer JK, Bindra R, Dewaele D, Couvreur P, and Saltzman WM. PEGylated squalenoyl-gemcitabine nanoparticles for the treatment of glioblastoma, Biomaterials 105:136-144 (2016). [PCMID: in process] Deng Y, Yang F, Cocco E, Song E, Zhang J, Cui J, Mohideen M, Bellone S, Santin AD, and Saltzman WM. Improved intraperitoneal drug delivery with bioadhesive nanoparticles, Proceedings of the National Academy of Sciences 113:11453-11458 (2016). [PCMID: in process] Bahal R, McNeer NA, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, López-Giráldez F, Ricciardi A, Beloor J, Krause D, Kumar P, Gallagher PG, Braddock D, Saltzman WM, Ly DH, Glazer PM. In vivo correction of anemia in b-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery, Nature Communications, DOI: 10.1038/ncomms13304 (2016). [PCMID: in process]