Ruddle, Nancy Hartman - Yale University - Biological & Biomedical Sciences

个人简介

Nancy Ruddle is known for her discovery and analysis of lymphotoxin, a protein produced by T cells that plays a role in the protective immune system and destroys tumor cells. She and researchers in her laboratory have engaged in research on the lymphotoxin/tumor necrosis factor family, their regulation and roles in lymphoid organ development and pathogenesis of viral and autoimmune disease. The more than 170 scientific articles Ruddle has authored or co-authored have explored the immunology of such diseases as leukemia, experimental allergic encephalomyelitis and Leishmania amazonensis infection, among others. She continues to generate insight into the regulation and function of lymphoid organs through her analysis of the vessels crucial for their function. PhD Yale University (1968) BA Mount Holyoke College, Zoology (1962) Postdoctoral Fellow Yale University

研究领域

Lymphoid Tissue

近期论文

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Liao, S., Bentley, K., Lebrun, M., Lesslauer, W., Ruddle, F.H, and Ruddle, N.H. (2007). Transgenic lacZ under control of hec-6st regulatory sequences recapitulates endogenous gene expression on high endothelial venules. Proc. Nat. Acad. Sci. (USA) 104:4577-4582. Drayton, D.L., Liao, S., Mounzer, R.H., and Ruddle, N.H. (2006). Lymphoid organ development: from ontogeny to neogenesis. Nat. Immunol. 7:344-353. Marta, C.B., Oliver, A.R., Sweet, R.A., Pfeiffer, S.E., and Ruddle, N.H. Pathogenic Myelin Oligodendrocyte Glycoprotein Antibodies Recongize Glycosylated Epitopes and Perturb Oligodendrocyte Physiology. Proceedings of the National Academy of SciencesUSA 102(38) 2005 Heikenwalder, M., Zeller, N., Seeger, H., Prinz, M., Klohn, P.C., Schwarz, P., Ruddle, N.H., Weissmann, C., and Aguzzi, A. Chronic Lymphocytic Inflammation Specifies the Organ Tropism of Prions. Science 307(5712): 1107-1110, 2005. Drayton, D.L., Bonizzi, G., Ying, X., Liao, S., Karin, M., and Ruddle, N.H. ??? kinase complex a kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal associated lymphoid tissue. Journal of Immunology 173: 6161-6168, 2004. Soderberg, K.A., Linehan, M.M., Ruddle, N.H., and Iwasaki, A. MAdCAM-1 expressing sacral lymph node in the lymphotoxin-ß deficient mouse provides a site for immune generation following vaginal herpes simplex virus-2 infection. Journal of Immunology 173: 1908-1913, 2004. Drayton, D.L., Ying, Y., Lee, J., Lesslauer, W., and Ruddle, N.H. Ectopic LTaß Directs Lymphoid Lymphoid Organ Neogenesis with Concomitant Expression of Peripheral Node Addressin and a HEV-restricted Sulfotransferase. Journal of Experimental Medicine 197: 1153-63, 2003. Oliver A.R., Lyon G.M., and Ruddle N.H. Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice. Journal of Immunology 171: 462-468, 2003