Roy, Craig Russell - Yale University - Biological & Biomedical Sciences

个人简介

Craig Roy received his B.S. from Michigan State University in 1985 and earned his Ph.D. in Microbiology and Immunology at Stanford University in 1991 in the laboratory of Dr. Stanley Falkow. After completing a postdoctoral fellowship with Dr. Ralph Isberg in the Department of Molecular Microbiology at Tufts University School of Medicine in 1996, he was appointed as an Assistant Professor in the Department of Molecular Genetics and Microbiology at Stony Brook University. Dr. Roy became a founding member of the Department of Microbial Pathogenesis at Yale University in 1998 and serves as Vice-Chair. He currently holds the title of Waldemar Von Zedtwitz Professor of Microbial Pathogenesis and Immunobiology. Research in the Roy laboratory focuses on the host-pathogen interface. Using multi-disciplinary approaches his laboratory has discovered many novel mechanisms that intracellular pathogens use to modulate host membrane transport pathways, which allow these pathogens to evade cell autonomous defenses and create novel organelles that permit bacterial replication. PhD Stanford University (1991)

研究领域

Bacteria; Immune System; Macrophages; Protozoan Proteins; Legionella pneumophila; Coxiella burnetii; Vesicular Transport Proteins

近期论文

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The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation Choy A, Dancourt J, Mugo B, O'Connor TJ, Isberg RR, Melia TJ, Roy CR. (2012) The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation. Science. 2012 Oct 25. The Legionella pneumophila effector DrrA is sufficient to stimulate SNARE-dependent membrane fusion Arasaki K, Toomre DK, Roy CR. (2012) The Legionella pneumophila effector DrrA is sufficient to stimulate SNARE-dependent membrane fusion. Cell Host Microbe. 11(1):46-57. Modulation of Rab GTPase function by a protein phosphocholine transferase. Mukherjee S, Liu X, Arasaki K, McDonough J, Galán JE, Roy CR. (2011) Modulation of Rab GTPase function by a protein phosphocholine transferase. Nature. Aug 7. doi: 10.1038/nature10335. Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein Lührmann A, Nogueira CV, Carey KL, Roy CR. (2010) Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein. Proc Natl Acad Sci U S A 107(44):18997-9001. Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila Nogueira CV, Lindsten T, Jamieson AM, Case CL, Shin S, Thompson CB, Roy CR. (2009) Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila. PLoS Pathog. 5(6):e1000478. Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Pan X, Lührmann A, Satoh A, Laskowski-Arce MA, Roy CR. (2008). Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science. 320:1651-1654. Legionella pneumophila proteins that regulate Rab1 membrane cycling Ingmundson A, Delprato A, Lambright DG, Roy CR. (2007). Legionella pneumophila proteins that regulate Rab1 membrane cycling. Nature 450:365-9. Fielden LF, Moffatt JH, Kang Y, Baker MJ, Khoo CA, Roy CR, Stojanovski D, Newton HJ: A Farnesylated Coxiella burnetii Effector Forms a Multimeric Complex at the Mitochondrial Outer Membrane during Infection. Infect Immun. 2017 May; 2017 Apr 21. PMID: 28242621 Tørring T, Shames SR, Cho W, Roy CR, Crawford JM: Acyl Histidines: New N-Acyl Amides from Legionella pneumophila. Chembiochem. 2017 Apr 4; 2017 Mar 6. PMID: 28116768 Kohler LJ, Roy CR: Autophagic targeting and avoidance in intracellular bacterial infections. Curr Opin Microbiol. 2016 Dec 13; 2016 Dec 13. PMID: 27984783 Abshire CF, Dragoi AM, Roy CR, Ivanov SS: MTOR-Driven Metabolic Reprogramming Regulates Legionella pneumophila Intracellular Niche Homeostasis. PLoS Pathog. 2016 Dec; 2016 Dec 12. PMID: 27942021 Sherwood RK, Roy CR: Autophagy Evasion and Endoplasmic Reticulum Subversion: The Yin and Yang of Legionella Intracellular Infection. Annu Rev Microbiol. 2016 Sep 8. PMID: 27607556 Kohler LJ, Reed SC, Sarraf SA, Arteaga DD, Newton HJ, Roy CR: Erratum for Kohler et al., Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole. MBio. 2016 Sep 6; 2016 Sep 6. PMID: 27601576 Campodonico EM, Roy CR, Ninio S: Legionella pneumophila Type IV Effectors YlfA and YlfB Are SNARE-Like Proteins that Form Homo- and Heteromeric Complexes and Enhance the Efficiency of Vacuole Remodeling. PLoS One. 2016; 2016 Jul 26. PMID: 27459495 Kohler LJ, Reed SR, Sarraf SA, Arteaga DD, Newton HJ, Roy CR: Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole. MBio. 2016 Jul 19; 2016 Jul 19. PMID: 27435465 Marion CR, Wang J, Sharma L, Losier A, Lui W, Andrews N, Elias JA, Kazmierczak BI, Roy CR, Dela Cruz CS: Chitinase 3-Like 1 (Chil1) Regulates Survival and Macrophage-Mediated Interleukin-1β and Tumor Necrosis Factor Alpha during Pseudomonas aeruginosa Pneumonia. Infect Immun. 2016 Jul; 2016 Jun 23. PMID: 27141083 Bradley WP, Boyer MA, Nguyen HT, Birdwell LD, Yu J, Ribeiro JM, Weiss SR, Zamboni DS, Roy CR, Shin S: Primary Role for Toll-Like Receptor-Driven Tumor Necrosis Factor Rather than Cytosolic Immune Detection in Restricting Coxiella burnetii Phase II Replication within Mouse Macrophages. Infect Immun. 2016 Apr; 2016 Mar 24. PMID: 26787725 Cunha LD, Ribeiro JM, Fernandes TD, Massis LM, Khoo CA, Moffatt JH, Newton HJ, Roy CR, Zamboni DS: Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA. Nat Commun. 2015 Dec 21; 2015 Dec 21. PMID: 26687278