Rothlin, Carla Vanina - Yale University - Biological & Biomedical Sciences

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PhD University of Buenos Aires (2002)

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AXL receptor tyrosine kinase is required for T cell priming and antiviral immunitye. Schmid ET, Pang IK, Carrera Silva EA, Bosurgi L, Miner JJ, Diamond MS, Iwasaki A, Rothlin CV. (2016)AXL receptor tyrosine kinase is required for T cell priming and antiviral immunityeLIFE Jun 28;5. pii: e12414. doi: 10.7554/eLife.12414. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Chan PY, Carrera Silva EA, De Kouchkovsky D, Joannas LD, Hao L, Hu D, Huntsman S, Eng C, Licona-Limón P, Weinstein JS, Herbert DR, Craft JE, Flavell RA, Repetto S, Correale J, Burchard EG, Torgerson DG, Ghosh S, Rothlin CV. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science 352(6281):99-103. 2016 TAM Receptor Signaling in Immune Homeostasis. Rothlin CV, Carrera-Silva EA, Bosurgi L, Ghosh S. TAM Receptor Signaling in Immune Homeostasis. Annu Rev Immunol. 2015 33:355-91 Tumor intrinsic EGFR and macrophage induced TNF-a signaling cooperate to promote GBM progression through aPKC. Kusne Y, Carrera Silva E, Perry AS, Rushing EJ, Mandell EK, Dietrich J, Errasti A, Gibbs D, Berens ME, Loftus JC, Hulme C, Aldape K, Sanai N, Rothlin CV* and Ghosh S*. Tumor intrinsic EGFR and macrophage induced TNF-a signaling cooperate to promote GBM progression through aPKC. * co-corresponding authors. Science Signaling, 2014, 7(338), ra75. Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer. Bosurgi L, Bernink JH, Delgado Cuevas V, Gagliani N, Joannas L, Schmid ET, Booth CJ, Ghosh S and Rothlin CV. Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13091-6 T Cell-Derived Protein S Engages TAM Receptor Signaling in Dendritic Cells to Control the Magnitude of the Immune Response. Carrera Silva EA, Chan PY, Joannas L, Errasti AE, Gagliani N, Bosurgi L, Jabbour M, Perry A, Smith-Chakmakova F, Mucida D, Cheroutre H, Burstyn-Cohen T, Leighton JA, Lemke G, Ghosh S and Rothlin CV: T Cell-Derived Protein S Engages TAM Receptor Signaling in Dendritic Cells to Control the Magnitude of the Immune Response. Immunity. 2013 Jul 25;39 (1) :160-70. Epub 2013 Jul 11. Immunobiology of the TAM receptors. Nat Rev Immunol. Lemke G and Rothlin C.V. (2008). Immunobiology of the TAM receptors. Nat Rev Immunol 8(5): 327-336 TAM receptors are pleiotropic inhibitors of the innate immune response. Rothlin C.V, Ghosh S., Zuniga E., Oldstone M.B., Lemke G.E (2007). TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131(6): 1124-1136. Cabezón R, Carrera-Silva EA, Flórez-Grau G, Errasti AE, Calderón-Gómez E, Lozano JJ, España C, Ricart E, Panés J, Rothlin CV, Benítez-Ribas D: MERTK as negative regulator of human T cell activation. J Leukoc Biol. 2015 Apr; 2015 Jan 26. PMID: 25624460