Rinehart, Jesse - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Jesse Rinehart is an Associate Professor in the Department of Cellular & Molecular Physiology at the Yale University School of Medicine with a joint appointment in the Systems Biology Institute. Dr. Rinehart’s research aims to understand and “decode” the roles of protein phosphorylation in humans. His laboratory uses an innovative combination of quantitative phosphoproteomics and synthetic biology study protein phosphorylation in single proteins and protein networks. Recently, research in Dr. Rinehart’s laboratory has been accelerated by their Escherichia coli based technology that enables site-specific incorporation of phosphoserine into human proteins. Dr. Rinehart received his PhD in Molecular Biophysics and Biochemistry from Yale in 2005. He studied protein synthesis and the evolution of the genetic code during his graduate work with Dr. Dieter Söll. His did his postdoctoral research with Richard Lifton in the Department of Genetics at the Yale University School of Medicine and focused on understanding the role of protein phosphorylation in physiological systems. PhD Yale University School of Medicine (2004) MS Yale University (1999) BA Kalamazoo College (1998)

研究领域

Biochemistry; Biotechnology; Hypertension; Molecular Biology; Phosphoproteins; Proteomics

近期论文

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Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids. Amiram M, Haimovich AD, Fan C, Wang Y-S, Aerni H-R, Ioanna N, Moonan DW, Ma NJ, Rovner AJ, Hong SH, Kelleher NL, Goodman AL, Jewett MC, Soll D,Rinehart J, Isaacs FJ. Nature Biotechnology. Published online 16 November 2015. doi:10.1038/nbt.3372. A flexible codon in genomically recoded Escherichia coli permits programmable protein phosphorylation. Pirman NL, Barber KW, Ma NJ, Haimovich AD, Rogulina S, Isaacs FJ, and Rinehart J. Nature Communications. 2015. 6, 8130. Robust Production of Recombinant Phosphoproteins Using Cell-Free Protein Synthesis. Oza JP, Aerni HR, Pirman NL, Rogulina S, ter Haar CM, Isaacs FJ, Rinehart J, and Jewett MC. Nature Communications 2015. 6, 8168 The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy. Heo JM, Ordureau A, Paulo JA, Rinehart J, Harper JW. Molecular Cell. 2015. Sep 9. pii: S1097-2765(15)00662-0. doi: 10.1016/j.molcel.2015.08.016. [Epub ahead of print]. Genomically recoded organisms expand biological functions. Lajoie MJ, Rovner AJ, Goodman DB, Aerni HR, Haimovich AD, Kuznetsov G, Mercer JA, Wang HH, Carr PA, Mosberg JA, Rohland N, Schultz PG, Jacobson JM, Rinehart J, Church GM, Isaacs FJ. Genomically recoded organisms expand biological functions. Science. 2013 Oct 18;342(6156):357-60. Expanding the genetic code of Escherichia coli with phosphoserine. Park H-S, Hohn M, Umehara T, Guo L-T, Osborne E, Benner J, Noren CJ, Rinehart J, and Söll D. (2011) Expanding the genetic code of Escherichia coli with phosphoserine. Science. Aug 26;333(6046):1151-4. Sites of regulated phosphorylation that control K-Cl cotransporter activity. Rinehart J, Maksimova YD , Tanis JE, Stone KE, Hodson CA, Zhang J, Risinger M, Pan W, Wu D, Colangelo CM, Forbush B, Joiner CH, Gulcicek EE, Gallagher PG, and Lifton RP. (2009) Sites of regulated phosphorylation that control K-Cl cotransporter activity. Cell. Aug 7;138(3):525-36. Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia. Shibata S, Rinehart J, Zhang J, Moeckel G, Castañeda-Bueno M, Stiegler AL, Boggon TJ, Gamba G, Lifton RP. Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia. Cell Metabolism. 2013 Nov 5;18(5):660-71. Mohler K, Mann R, Bullwinkle TJ, Hopkins K, Hwang L, Reynolds NM, Gassaway B, Aerni HR, Rinehart J, Polymenis M, Faull K, Ibba M: Editing of misaminoacylated tRNA controls the sensitivity of amino acid stress responses in Saccharomyces cerevisiae. Nucleic Acids Res. 2017 Apr 20. PMID: 28168297 Park HB, Perez CE, Barber KW, Rinehart J, Crawford JM: Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase biosynthetic gene cluster. Elife. 2017 Mar 15; 2017 Mar 15. PMID: 28431213 Castañeda-Bueno M, Arroyo JP, Zhang J, Puthumana J, Yarborough O 3rd, Shibata S, Rojas-Vega L, Gamba G, Rinehart J, Lifton RP: Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4. Proc Natl Acad Sci U S A. 2017 Jan 31; 2017 Jan 17. PMID: 28096417 Mohler K, Aerni HR, Gassaway B, Ling J, Ibba M, Rinehart J: MS-READ: Quantitative measurement of amino acid incorporation. Biochim Biophys Acta. 2017 Jan 24; 2017 Jan 24. PMID: 28130155 Padovano V, Kuo IY, Stavola LK, Aerni HR, Flaherty BJ, Chapin HC, Ma M, Somlo S, Boletta A, Ehrlich BE, Rinehart J, Caplan MJ: The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function. Mol Biol Cell. 2017 Jan 15; 2016 Nov 23. PMID: 27881662 Ferdaus MZ, Barber KW, López-Cayuqueo KI, Terker AS, Argaiz ER, Gassaway BM, Chambrey R, Gamba G, Rinehart J, McCormick JA: SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule. J Physiol. 2016 Sep 1; 2016 May 29. PMID: 27068441 Amiram M, Haimovich AD, Fan C, Wang YS, Aerni HR, Ntai I, Moonan DW, Ma NJ, Rovner AJ, Hong SH, Kelleher NL, Goodman AL, Jewett MC, Söll D, Rinehart J, Isaacs FJ: Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids. Nat Biotechnol. 2015 Dec; 2015 Nov 16. PMID: 26571098 Heo JM, Ordureau A, Paulo JA, Rinehart J, Harper JW: The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy. Mol Cell. 2015 Oct 1; 2015 Sep 10. PMID: 26365381 Oza JP, Aerni HR, Pirman NL, Barber KW, ter Haar CM, Rogulina S, Amrofell MB, Isaacs FJ, Rinehart J, Jewett MC: Robust production of recombinant phosphoproteins using cell-free protein synthesis. Nat Commun. 2015 Sep 9; 2015 Sep 9. PMID: 26350765 Pirman NL, Barber KW, Aerni HR, Ma NJ, Haimovich AD, Rogulina S, Isaacs FJ, Rinehart J: A flexible codon in genomically recoded Escherichia coli permits programmable protein phosphorylation. Nat Commun. 2015 Sep 9; 2015 Sep 9. PMID: 26350500 Hoesl MG, Oehm S, Durkin P, Darmon E, Peil L, Aerni HR, Rappsilber J, Rinehart J, Leach D, Söll D, Budisa N: Chemical Evolution of a Bacterial Proteome. Angew Chem Int Ed Engl. 2015 Aug 17; 2015 Jul 1. PMID: 26136259 Ordureau A, Heo JM, Duda DM, Paulo JA, Olszewski JL, Yanishevski D, Rinehart J, Schulman BA, Harper JW: Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy. Proc Natl Acad Sci U S A. 2015 May 26; 2015 May 12. PMID: 25969509 Lin DH, Yue P, Yarborough O 3rd, Scholl UI, Giebisch G, Lifton RP, Rinehart J, Wang WH: Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK). Proc Natl Acad Sci U S A. 2015 Apr 7; 2015 Mar 24. PMID: 25805816