Reinke, Valerie - Yale University - Biological & Biomedical Sciences

个人简介

Valerie Reinke attended University of Illinois, receiving her B.S. in Genetics in 1990. She then went to University of Texas Health Sciences Center in Houston, Texas for graduate work in the laboratory of Gigi Lozano. There she studied mechanisms of tumor suppression by the factor p53, and received her PhD in Biomedical Sciences in 1996. Valerie performed her postdoctoral work in the laboratory of Stuart Kim at Stanford University in California, focusing on initiating genomic studies of a model organism, the nematode C. elegans. While there, she developed an interest in the role of gene expression in regulating C. elegans germline development. In 2000, she joined the faculty of the Department of Genetics at Yale University School of Medicine, and continues to apply genome-wide technologies to understanding gene regulatory mechanisms in the germ line. PhD University of Texas (1996)

研究领域

Genetics; Germ Cells; Stem Cells; Developmental Biology; Caenorhabditis elegans; Genomics; Epigenomics

近期论文

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The C. elegans SNAPc component SNPC-4 coats piRNA domains and is globally required for piRNA abundance. Kasper DM, Wang G, Gardner KE, Johnstone TG, Reinke V. Dev Cell. 2014 Oct 27;31(2):145-58 Homeland security in the C. elegans germ line: insights into the biogenesis and function of piRNAs. Kasper DM, Gardner KE, Reinke V. Epigenetics. 2014 Jan;9(1):62-74. Regulatory analysis of the C. elegans genome with spatiotemporal resolution Araya CL, Kawli T, Kundaje A, Jiang L, Wu B, Vafeados D, Terrell R, Weissdepp P, Gevirtzman L, Mace D, Niu W, Boyle AP, Xie D, Ma L, Murray JI, Reinke V, Waterston RH, Snyder M. Nature. 2014 Aug 28;512(7515):400-5 Tissue-specific direct targets of Caenorhabditis elegans Rb/E2F dictate distinct somatic and germline programs. Kudron M, Niu W, Lu Z, Wang G, Gerstein M, Snyder M, Reinke V. Genome Biol. 2013 Jan 23;14(1):R5 C. elegans meg-1 and meg-2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival. Kapelle WS, Reinke V. Genesis. 2011 May;49(5):380-91. The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis. Schober CS, Aydiner F, Booth CJ, Seli E, Reinke V. Mech Dev. 2011 Mar-Apr;128(3-4):178-90. A spatial and temporal map of C. elegans gene expression. Spencer WC, Zeller G, Watson JD, Henz SR, Watkins KL, McWhirter RD, Petersen S, Sreedharan VT, Widmer C, Jo J, Reinke V, Petrella L, Strome S, Von Stetina SE, Katz M, Shaham S, Rätsch G, Miller DM 3rd. Genome Res. 2011 Feb;21(2):325-41. Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans. Niu W, Lu ZJ, Zhong M, Sarov M, Murray JI, Brdlik CM, Janette J, Chen C, Alves P, Preston E, Slightham C, Jiang L, Hyman AA, Kim SK, Waterston RH, Gerstein M, Snyder M, Reinke V. Genome Res. 2011 Feb;21(2):245-54. Genome-wide identification of binding sites defines distinct functions for Caenorhabditis elegans PHA-4/FOXA in development and environmental response. Zhong M, Niu W, Lu ZJ, Sarov M, Murray JI, Janette J, Raha D, Sheaffer KL, Lam HY, Preston E, Slightham C, Hillier LW, Brock T, Agarwal A, Auerbach R, Hyman AA, Gerstein M, Mango SE, Kim SK, Waterston RH, Reinke V, Snyder M. Genome-wide identification of binding sites defines distinct functions for Caenorhabditis elegans PHA-4/FOXA in development and environmental response. PLoS Genet. 2010 Feb 19;6(2):e1000848 Genome-wide analysis of germ cell proliferation in C.elegans identifies VRK-1 as a key regulator of CEP-1/p53. Waters K, Yang AZ, Reinke V. Dev Biol. 2010 Aug 15;344(2):1011-25. DPL-1 (DP) acts in the germ line to coordinate ovulation and fertilization in C. elegans. Chi W, Reinke V. Mech Dev. 2009 May-Jun;126(5-6):406-16 Massively parallel sequencing of the polyadenylated transcriptome of C. elegans. Hillier LW, Reinke V, Green P, Hirst M, Marra MA, Waterston RH. Genome Res. 2009 Apr;19(4):657-66. A C. elegans Piwi, PRG-1, regulates 21U-RNAs during spermatogenesis.