Qyang, Yibing - Yale University - Biological & Biomedical Sciences

个人简介

Yibing Qyang obtained his B.S. degree from the Department of Biochemistry, Nanjing University, China and subsequently pursued graduate studies at the Institute of Microbiology, Chinese Academy of Sciences. Then he joined the Department of Molecular Genetics, University of Texas M.D. Anderson Cancer Center. After receiving his M.S. degree from Dr. Michele Sawadogo’s laboratory, and his Ph.D. from Dr. Stevan Marcus’s lab, he spent the next year conducting postdoctoral research at Baylor College of Medicine, where he studied myeloproliferative diseases with a mouse model of Presenilin deficiency. He next joined Dr. Kenneth R. Chien's laboratory at the University of California, San Diego and then the Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School and Harvard Stem Cell Institute. He has been studying the renewal and differentiation of cardiovascular progenitor cells, marked by Isl1, a LIM-Homeodomain transcription factor, as well as cardiovascular disease mechanisms using human stem cell and animal models. In October 2008, Dr. Qyang became a principal investigator at the Yale Cardiovascular Research Institute and Section of Cardiology, Dept. of Internal Medicine, and Yale Stem Cell Center. Since 2010, he has been Director of the Yale Stem Cell Research Forum. PhD University of Texas M.D. Anderson Cancer Center (2002) MS University of Texas M.D. Anderson Cancer Center (1999)

研究领域

Cardiology; Cardiovascular Diseases; Heart; Physiology; Stem Cells; Tissue Engineering

近期论文

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Oscar Bartulos, PhD, Zhen Wu Zhuang, MD, Yan Huang, PhD, Nicole Mikush, BS, Carol Suh, MS, Alda Bregasi, MD, Lin Wang, MS, William Chang, MD, PhD, Diane S. Krause, MD, PhD, Lawrence H. Young, MD Jordan S. Pober, MD, PhD, Yibing Qyang, PhD. ISL1 Cardiovascular Progenitor Cells for Cardiac Repair after Myocardial Infarction. JCI Insight 2016 (Accepted and In Press). Liqiong Gui, Biraja C. Dash, Jiesi Luo, Lingfeng Qin, Liping Zhao, Kota Yamamoto, Takuya Hashimoto, Hongwei Wu, Alan Dardik, George Tellides, Laura E. Niklason, Yibing Qyang. Implantable Tissue-Engineered Blood Vessels from Human Induced Pluripotent Stem Cells. Biomaterials 2016, 102:120-129 (Available online 14 June 2016). Biraja C. Dash, Karen Levi, Jonas Schwan, Jiesi Luo, Oscar Bartulos, Hongwei Wu, Caihong Qiu, Ting Yi, Yongming Ren, Stuart Campbell, Marsha W. Rolle, Yibing Qyang. Tissue-Engineered Vascular Rings from Human iPSC-Derived Smooth Muscle Cells . Stem Cell Reports 2016 (Accepted and In Press). Misra A, Sheikh AQ, Kumar A, Luo J, Zhang J, Hinton RB, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif DM. Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis. J Exp Med. 2016 Mar 7;213(3):451-63. doi: 10.1084/jem.20150688. Epub 2016 Feb 8. Induced Pluripotent Stem Cell-derived Vascular Smooth Muscle Cells: Methods and Application. Biraja C. Dash, Zhengxin Jiang, Carol Suh, Yibing Qyang (2015). Induced Pluripotent Stem Cell-derived Vascular Smooth Muscle Cells: Methods and Application. Biochemical Journal 2015, 465(2):185-94. Efficient Gene Disruption in Cultured Primary Human Endothelial Cells by CRISPR/Cas9 Abrahimi P, Chang WG, Kluger MS, Qyang Y, Tellides G, Saltzman WM, Pober JS. Efficient Gene Disruption in Cultured Primary Human Endothelial Cells by CRISPR/Cas9. Circ Res. 2015, 117(2):121-8 Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor Sivarapatna A, Ghaedi M, Le AV, Mendez JJ, Qyang Y, Niklason LE. Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor. Biomaterials, 2015, 53:621-33. Advancements in Induced Pluripotent Stem Cell Technology for Cardiac Regenerative Medicine. Suh CY, Wang Z, Bártulos O, Qyang Y. Advancements in Induced Pluripotent Stem Cell Technology for Cardiac Regenerative Medicine. J Cardiovasc Pharmacol Ther. 2014, 19;19(4):330-339. Functional cardiomyocytes derived from Isl1 cardiac progenitors via Bmp4 stimulation Esra Cagavi, Oscar Bartulos, Carol Y. Suh, Baonan Sun, Zhichao Yue, Zhengxin Jiang, Lixia Yue, Yibing Qyang. Functional cardiomyocytes derived from Isl1 cardiac progenitors via Bmp4 stimulation. PLOS ONE 2014, 9(12):e110752. Bone Morphogenetic Protein 2 Signaling Negatively Modulates Lymphatic Development in Vertebrate Embryos Dunworth WP, Cardona-Costa J, Cagavi E, Kim JD, Fischer JC, Meadows S, Wang Y, Cleaver O, Qyang Y, Ober EA, Jin SW. Bone Morphogenetic Protein 2 Signaling Negatively Modulates Lymphatic Development in Vertebrate Embryos. Circ Res. 2014, 114(1):56-66. Rapamycin Inhibits Smooth Muscle Cell Proliferation and Obstructive Arteriopathy Attributable to Elastin Deficiency Li W, Li Q, Qin L, Ali R, Qyang Y, Tassabehji M, Pober BR, Sessa WC, Giordano FJ, Tellides G (2013). Rapamycin Inhibits Smooth Muscle Cell Proliferation and Obstructive Arteriopathy Attributable to Elastin Deficiency. Arterioscler Thromb Vasc Biol. 2013, 33(5):1028-35. Modeling Supravalvular Aortic Stenosis Syndrome Using Human Induced Pluripotent Stem Cells. X. Ge, Y. Ren, Z. Yue, K. Kim, M. Lee, W. Li, P. Amos, E. Bozkulak, W. Zheng, H. Zhao, K. Martin, D. Kotton, G. Tellides, I. Park, L. Yue, Y. Qyang (2012). Modeling Supravalvular Aortic Stenosis Syndrome Using Human Induced Pluripotent Stem Cells. Circulation 2012, 126 (14):1695-1704. Context-Dependent Proangiogenic Function of Bone Morphogenetic Protein Signaling Is Mediated by Disabled Homolog 2