Pyle, Anna Marie - Yale University - Biological & Biomedical Sciences

个人简介

Anna Marie Pyle is the William Edward Gilbert Professor of Molecular, Cellular and Developmental Biology and Professor of Chemistry at Yale University.She has been a Howard Hughes Medical Institute Investigator since 1997.Dr. Pyle obtained her undergraduate degree in Chemistry from Princeton University and received her Ph.D. in Chemistry from Columbia University in 1990, where she worked with Professor Jacqueline K. Barton. Dr. Pyle was a postdoctoral fellow in the laboratory of Thomas Cech at the University of Colorado. Dr. Pyle formed her own research group in 1992 in the Department of Biochemistry and Molecular Biophysics at Columbia University Medical Center.In 2002, she moved to Yale University, where she leads a research group that specializes in structure and function of large RNA molecules and RNA remodeling enzymes.Dr. Pyle teaches the undergraduate Molecular Biology course at Yale and she is Chair of the Building Committee for the new Yale Biology Building.Dr. Pyle is the Chair of the MSFA Study Section at the NIH, and previously served as a permanent member on the MSFE, and MGB Study Sections.At Brookhaven National labs, she serves on the Science and Technology Steering Committee and on Beamline Advisory Teams at the NSLSII light source.Dr. Pyle is the Co-Editor of Methods in Enzymology and serves on the Editorial Board of the Journal of Molecular Biology.Dr. Pyle is the author of over 150 publications and has mentored more than 40 graduate students and postdocs.The Pyle laboratory uses a diverse set of biochemical techniques, including crystallography and enzymology, to understand the structural complexity of large RNA molecules. She pioneered the study of RNA helicase enzymes and other RNA-stimulated ATPases that serve as translocases, RNA remodeling enzymes and signaling enzymes in the cell.Her experimental work is complemented by efforts to develop new computational tools for modeling, analyzing and predicting RNA structure. Postdoctoral Fellow University of Colorado

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Somarowthu, S., Legiewicz, M., Chillón, I., Marcia, M., Liu, F. and Pyle A.M. (2015) HOTAIR forms an intricate and modular secondary structure. Mol Cell. 58, 353-361. Rawling, D.C., Kohlway, A.S., Luo, D., Ding, S.C. and Pyle AM. (2014) The RIG-I ATPase core has evolved a functional requirement for allosteric stabilization by the Pincer domain. Nucleic Acids Res. 42, 11601-11. Kohlway, A., Pirakitikulr, N., Ding, S.C., Yang, F., Luo, D., Lindenbach, B.D. and Pyle, A.M. (2014) The linker region of NS3 plays a critical role in the replication and infectivity of hepatitis C virus. J Virol., 88, 10970-10974. Rawling, D.C. and Pyle, A.M. (2014) Parts, assembly and operation of the RIG-I family of motors. Curr Opin Struct Biol., 25, 25-33. Marcia, M. and Pyle, A.M. (2014) Principles of ion recognition in RNA: insights from the group II intron structures. RNA, 20, 516-27. Kohlway, A., Luo, D., Rawling, D.C., Ding, S.C. and Pyle, A.M. (2013) Defining the functional determinants for RNA surveillance by RIG-I. EMBO Rep. 14, 772-9. Zhao C, Pyle AM: The group II intron maturase: a reverse transcriptase and splicing factor go hand in hand. Curr Opin Struct Biol. 2017 May 18; 2017 May 18. PMID: 28528306 Adams RL, Pirakitikulr N, Pyle AM: Functional RNA structures throughout the Hepatitis C Virus genome. Curr Opin Virol. 2017 May 13; 2017 May 13. PMID: 28511116 Zhao C, Pyle AM: Structural Insights into the Mechanism of Group II Intron Splicing. Trends Biochem Sci. 2017 Apr 21; 2017 Apr 21. PMID: 28438387 Liu F, Somarowthu S, Pyle AM: Visualizing the secondary and tertiary architectural domains of lncRNA RepA. Nat Chem Biol. 2017 Mar; 2017 Jan 9. PMID: 28068310 Schlick T, Pyle AM: Opportunities and Challenges in RNA Structural Modeling and Design. Biophys J. 2017 Feb 2; 2017 Feb 2. PMID: 28162235 Fitzgerald ME, Rawling DC, Potapova O, Ren X, Kohlway A, Pyle AM: Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding. Nucleic Acids Res. 2016 Sep 12; 2016 Sep 12. PMID: 27625396 Pyle AM: Group II Intron Self-Splicing. Annu Rev Biophys. 2016 Jul 5. PMID: 27391926 Zhao C, Pyle AM: Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution. Nat Struct Mol Biol. 2016 Jun; 2016 May 2. PMID: 27136328 Pyle AM, Schlick T: Challenges in RNA Structural Modeling and Design. J Mol Biol. 2016 Feb 27; 2016 Feb 12. PMID: 26876599 Lilley DM, Pyle AM: Editorial overview: Nucleic acids and their protein complexes. Curr Opin Struct Biol. 2016 Feb; 2016 Mar 2. PMID: 26948825 Zhao C, Rajashankar KR, Marcia M, Pyle AM: Crystal structure of group II intron domain 1 reveals a template for RNA assembly. Nat Chem Biol. 2015 Dec; 2015 Oct 26. PMID: 26502156 Rawling DC, Fitzgerald ME, Pyle AM: Establishing the role of ATP for the function of the RIG-I innate immune sensor. Elife. 2015 Sep 15; 2015 Sep 15. PMID: 26371557 Somarowthu S, Legiewicz M, Chillón I, Marcia M, Liu F, Pyle AM: HOTAIR forms an intricate and modular secondary structure. Mol Cell. 2015 Apr 16; 2015 Apr 9. PMID: 25866246 Pyle AM: Rediscovering RNA. RNA. 2015 Apr. PMID: 25780205 Foxman EF, Storer JA, Fitzgerald ME, Wasik BR, Hou L, Zhao H, Turner PE, Pyle AM, Iwasaki A: Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells. Proc Natl Acad Sci U S A. 2015 Jan 20; 2015 Jan 5. PMID: 25561542 Chillón I, Marcia M, Legiewicz M, Liu F, Somarowthu S, Pyle AM: Native Purification and Analysis of Long RNAs. Methods Enzymol. 2015; 2015 Feb 27. PMID: 26068736 Pyle AM: Looking at LncRNAs with the ribozyme toolkit. Mol Cell. 2014 Oct 2. PMID: 25280101 Rawling DC, Kohlway AS, Luo D, Ding SC, Pyle AM: The RIG-I ATPase core has evolved a functional requirement for allosteric stabilization by the Pincer domain. Nucleic Acids Res. 2014 Oct; 2014 Sep 12. PMID: 25217590 Fitzgerald ME, Rawling DC, Vela A, Pyle AM: An evolving arsenal: viral RNA detection by RIG-I-like receptors. Curr Opin Microbiol. 2014 Aug; 2014 Jun 7. PMID: 24912143