Pollard, Thomas Dean - Yale University - Biological & Biomedical Sciences

个人简介

A graduate of Pomona College, Dr. Thomas D. Pollard, earned his M.D. from Harvard Medical School. He taught at Harvard Medical School 1972-78 and joined the Johns Hopkins University School of Medicine as the Bayard Halsted Professor and founding director of the Department of Cell Biology and Anatomy in 1977. At Johns Hopkins, was the founding director of a graduate program in cellular and molecular medicine and was honored with teaching awards seven times. He joined the Salk Institute as President in 1996. He has also served as adjunct professor at the University of California at San Diego until he moved to Yale University in 2001. He has had a long affiliation with the Marine Biological Laboratory in Woods Hole, Massachusetts. Pollard was president of both the American Society for Cell Biology and the Biophysical Society, and on behalf of these organizations he was active politically in support of funding for biomedical research. He chaired the Commission on Life Sciences at the National Research Council 1993-98. Honors include election to the National Academy of Sciences, the American Academy of Arts and Sciences and the Institute of Medicine, the Rosensteil Medical Research Award from Brandeis University with James Spudich of Stanford University (1996), the Howard T. Ricketts Award from the University of Chicago (2000), the E.B. Wilson Medal from the American Society for Cell Biology (2004) and the Gairdner International Award in Biomedical Sciences (2006). His other honors include a Guggenheim Fellowship, a MERIT Award from the National Institute of General Medical Science, a Public Service Award from the Biophysical Society and a Winston Churchill Overseas Fellowship from Churchill College in Cambridge, England. Pollard has authored or coauthored more than 400 scientific papers and scholarly articles on his work. MD Harvard Medical School (1968) BA Pomona College (1964) Intern Massachusetts General Hospital, Boston, MA

研究领域

Cell Biology; Molecular Biology; Myosins; Cytokinesis

近期论文

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Assembly mechanism of the contractile ring for cytokinesis by fission yeast. Vavylonis, D., Wu, J.-Q., Hao, S., O'Shaughnessy, B. and Pollard, T.D. (2008) Assembly mechanism of the contractile ring for cytokinesis by fission yeast. Science 319:97-100. Control of the assembly of ATP- and ADP-actin by formins and profilin. Kovar, D.R., Harris, E.S., Mahaffy, R.E., Higgs, H.N., and Pollard, T.D. (2006). Control of the assembly of ATP- and ADP-actin by formins and profilin. Cell 724:423-435. Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis. Wu, J-Q., Kuhn, J. R., Kovar, D. R. and Pollard, T. D. Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis. Devel. Cell 5, 723-734 (2003) The role of the FH1 domain and profilin in formin-mediated actin filament elongation and nucleation. Paul, A. and Pollard, T. D. The role of the FH1 domain and profilin in formin-mediated actin filament elongation and nucleation. Curr. Biol. 18, 9-19 (2008) Insights into the influence of nucleotides on the actin family of proteins from seven crystal structures of bovine Arp2/3 complex. Nolen, B. and Pollard, T. D. Insights into the influence of nucleotides on the actin family of proteins from seven crystal structures of bovine Arp2/3 complex. Mol. Cell 26, 449-457 (2007) Mechanism of cytokinetic ring constriction in fission yeast. Stachowiak, M.R., Laplante, C., Chin, H.F., Guirao, B., Karatekin, E., Pollard. T.D. and O’Shaughnessy, B. (2014) Mechanism of cytokinetic ring constriction in fission yeast. Devel. Cell 29:547-561. Cytokinetic nodes in fission yeast arise from two distinct types of nodes that merge during interphase. Akamatsu, M.S., Berro, J., Pu, K.-M., Tebbs, I.R. and Pollard, T.D. (2014) Cytokinetic nodes in fission yeast arise from two distinct types of nodes that merge during interphase. J. Cell Biol. 204:977-988. Actin filament severing by cofilin contributes to both assembly and disassembly of endocytic actin patches Chen, Q. and Pollard, T.D. (2013) Actin filament severing by cofilin contributes to both assembly and disassembly of endocytic actin patches. Curr. Biol. 23:1154-1162. Distinct roles for F-BAR proteins Cdc15p and Bzz1p in actin polymerization at sites of endocytosis in fission yeast. Arasada, R. and Pollard, T.D. (2011) Distinct roles for F-BAR proteins Cdc15p and Bzz1p in actin polymerization at sites of endocytosis in fission yeast. Current Biol. 21:1450-1459. Structural and biochemical characterization of two binding sites for nucleation promoting factor WASp-VCA on Arp2/3 complex. Ti, S.-C., Jurgenson, C., Nolen, B.J., and Pollard, T.D. (2011) Structural and biochemical characterization of two binding sites for nucleation promoting factor WASp-VCA on Arp2/3 complex. Proc. Natl. Acad. Sci. USA 108:E463-71. Local and global analysis of endocytic patches dynamics in fission yeast using a new “temporal super-resolution” realignment method. Berro, J. and Pollard, T.D. (2014) Molec. Biol. Cell. 25:3501-3514. Three myosins contribute uniquely to the assembly and constriction of the cytokinetic contractile ring in fission yeast Laplante, C., Berro, J., Karatekin, E., Lee, R., Hernandez-Leyva, A. and Pollard, T.D. (2015) Curr. Biol. 25:1955-1965. Avoiding artifacts when counting polymerized actin in live cells with Lifeact fused to fluorescent proteins Courtemanche, N., Pollard, T.D. and Chen, Q. (2016) Nature Cell Biol. 18:676-683