Pober, Jordan Stuart - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Pober was born in Brooklyn, New York in 1949 and grew up in the New York City metropolitan area. He attended Haverford College, graduating summa cum laude in 1971 with high honors in Biology, Chemistry and History. He was admitted to Yale’s Medical Scientist Training Program, receiving his MD and his PhD in Molecular Biophysics and Biochemistry with Prof. Lubert Stryer in 1977. He completed his first year of pathology residency at Yale-New Haven Hospital in 1978, was a post-doctoral fellow with Prof. Jack Strominger in the Department of Biochemistry at Harvard University from 1978 through 1980, and completed pathology training at Brigham and Women’s Hospital in 1981. He worked as an attending Pathologist at Brigham and Women’s Hospital from 1981-1991, serving as an Assistant Professor and then Associate Professor of Pathology at Harvard Medical School during the same period. He returned to Yale Medical School in 1991 as a Professor of Pathology and Immunobiology, and also became a Professor of Dermatology in 1998. Dr. Pober was named the Director of the Molecular Cardiobiology Program at the Boyer Center for Molecular Medicine in 1991 and founded the Vascular Biology and Transplantation (VBT) Program, which succeeded Molecular Cardiobiology, in 1999. In 2007, he stepped down as the director of the VBT program, becoming Professor and Vice-Chair of the Department of Immunobiology for the Section of Human and Translational Immunology. He was named Ensign Professor of Immunobiology in 2011 and Bayer Professor of Translational Medicine in 2012. Dr. Pober has been honored as a Searle Scholar, an Established Investigator of the American Heart Association and a MERIT awardee of the National Heart, Lung and Blood Institute. He received the Warner Lambert-Parke Davis award in 1988 and the Rous Whipple Award in 2011 from the American Society of Investigative Pathology and the Earl Benditt award from the North American Vascular Biology Organization in 2014. He has served as an Editor of Immunity and Co-Editor-in Chief of Laboratory Investigation, leading immunology and pathology journals, respectively. He also has served as President of the North American Vascular Biology Organization. He is co-founder and co-director of the Joint Yale-Cambridge University Biomedical Research Program, is a visiting fellow in the Dept. Of medicine at the University of Cambridge, and was elected a Fellow Commoner of Trinity Hall, University of Cambridge in 2012. He serves on the Executive Committee of the Community of Basic Scientists of the American Society of Transplantation. Dr. Pober’s research involves understanding the functions of vascular endothelial cells in inflammatory and immune responses and, reciprocally, how inflammation and immunity affect vascular health and function. He is particularly interested in how insights from experiments with human cells and tissues and with humanized mice can be used to improve organ replacement therapy, to improve tissue engineering and to regenerate injured tissues. PhD Yale University (1977) MD Yale University (1977) Resident Yale-New Haven Hospital Resident Brigham and Women's Hospital Fellow Harvard University

研究领域

Immune System; Transplantation Immunology; Cytokines; Endothelial Cells; Translational Medical Research

近期论文

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Interferon-γ-mediated allograft rejection exacerbates cardiovascular disease of hyperlipidemic murin transplant recipients. Zhou J, Qin L, Yi T, Ali R, Qingle L, Yang J, Li G, Tobiasova Z, Yan H, Zhang J, Yun JL, Sadeghi M, Giordano FJ, Pober JS, Tellides G. Interferon-γ-mediated allograft rejection exacerbates cardiovascular disease of hyperlipidemic murin transplant recipients. Circ Res. 2015; (Epub ahead of print) Complement membrane attack complexes activate noncanonical NF-B by forming an Akt+NIK+ signalosome on Rab5+ endosomes. Jane-wit D, Surovtseva YV, Qin l, Li G, Liu R, Clark P, Manes TD, Wang C, Kashgarian M, Kirkiles-Smith NC, Tellides G, Pober JS. Complement membrane attack complexes activate noncanonical NF-B by forming an Akt+NIK+ signalosome on Rab5+ endosomes. Proc Natl Acad Sci (USA) 2015; 112:9686-9691 Efficient gene disruption in cultured primary human endothelial cells by CRISPR/Cas9 Abrahimi P, Chang WG, Kluger MS, Qyang Y, Tellides G, Saltzman WM, Pober JS. Efficient gene disruption in cultured primary human endothelial cells by CRISPR/Cas9. Circ Res. 2015;117:121-128. Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-kappa B-dependent phases. Clark P, Kim RK, Pober JS, Kluger MS. Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-kappa B-dependent phases. PLoSOne 2015;10:e0120075. CyTOF supports efficient detection of immune cell subsets from small samples. Yao Y, Liu R, Shin MS, Trentalange M, Allore H, Nassar A, Kang I, Pober JS, Montgomery RR. CyTOF supports efficient detection of immune cell subsets from small samples. J Immunol Methods 2014; 415:1-5. TL1-A can engage death receptor-3 and activate NF-kappa B in endothelial cells. Wang J, Al-Lamki RS, Zhu X, Liu H, Pober JS, Bradley JR. TL1-A can engage death receptor-3 and activate NF-kappa B in endothelial cells. BMC Nephrol 2014; 15:178. Tissue-engineered microvasculature to perfuse isolated renal glomeruli. Chang WG, Fornoni A, Tietjen G, Mendez JJ, Nicklason LE, Saltzman WM, Pober JS. Tissue- engineered microvasculature to perfuse isolated renal glomeruli. Tissue Eng Part A 2015; (Epub ahead of print) Polarized granzyme release is required for antigen-driven transendothelial migration of human effector memory CD4 T cells. Manes T, Pober JS. Polarized granzyme release is required for antigen-driven transendothelial migration of human effector memory CD4 T cells. J Immunol. 2014; 193:5809-5815. Rapamycin antagonizesTNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2 Wang C, Qin L, Manes TD, Kirkiles-Smith NC, Tellides G, Pober JS. Rapamycin antagonizesTNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2. J Exp Med. 2014;211:395-404. Infantile hemangiomas exhibit neural crest and pericyte markers. Spock CL, Tom LK, Canadas K, Sue GR, Sawh-Martinez R, Maier CL, Pober JS, Galan A, Schultz B, Waner M, Narayan D, Licinio J, Wong ML. Infantile hemangiomas exhibit neural crest and pericyte markers. Annals of Plastic Surgery 2015; 74:230-236. A composite model of the human postcapillary venule for investigation of microvascular leukocyte recruitment. Lauridsen H, Pober JS, Gonzalez AL. A composite model of the human postcapillary venule for investigation of microvascular leukocyte recruitment. FASEB J. 2014; 28:1166-1180. Sustained delivery of proangiogenic microRNA-132 by nanoparticle transfection improves endothelial cell transplantation. Devalliere J, Chang WG, Andrejecsk JW, Abrahimi P, Cheng CJ, Jane-wit D, Saltzman WM, Pober, JS. Sustained delivery of proangiogenic microRNA-132 by nanoparticle transfection improves endothelial cell transplantation. FASEB J. 2014: 28:908-922. Pericytes modulate endothelial sprouting.