Pittenger, Christopher - Yale University - Biological & Biomedical Sciences

个人简介

Christopher Pittenger earned his MD and Ph.D. degrees from Columbia University, where his graduate work was done with Nobel Prize recipient Eric Kandel. He returned to Yale University - where he had done his undergraduate studies - for residency and research training in psychiatry in 2003. He joined the faculty as an Assistant Professor in 2007 and was promoted to the rank of Associate Professor in 2013. During his Ph.D. studies in basic neurobiology, he became fascinated by the brain's ability to go on autopilot -- to perform complex series of actions or thoughts, after sufficient rehearsal, with almost no conscious effort. Then, during his clinical training, he recognized how this process, when disrupted by disease, can lead to the maladaptive and disruptive automaticity seen in many neuropsychiatric disorders. His research, both with patients and in animal models, aims to elucidate the mechanisms of learned automatic behaviors and to better understand the consequences when they go awry, with the ultimate goal of developing new understandings and better treatments for a variety of neuropsychiatric conditions. Dr. Pittenger's research and clinical work have been acknowledged by a number of prestigious awards, including grant funding from the National Institutes of Health, NARSAD, the Tourette Syndrome of America, and the Doris Duke Charitable Trust, and awards from the National Institute of Mental Health, the Society for Neuroscience, the American College of Neuropsychopharmacology, the American Psychiatric Association, and the American College of Psychiatrists. He is a member of the Scientific Advisory Board of the International OCD Foundation and an active member of the Society for Neuroscience, the American College of Neuropsychopharmacology, the Society of Biological Psychiatry, the American Neurological Association, the American Psychiatric Association, and other groups. MD Columbia College of Physicians and Surgeons (2003) PhD Columbia University (2002) MPhil Columbia University (1998) BS Yale University (1994) MS Yale University (1994) Diplomate American Board of Psychiatry and Neurology McNeil Research Fellow Yale University Resident in Adult Psychiatry Yale University Board Certification AB of Psychiatry & Neurology, Psychiatry (2010)

研究领域

Basal Ganglia Diseases; Tourette Syndrome; Learning; Molecular Biology; Neuroanatomy; Neurobiology; Neurophysiology; Neurosciences; Obsessive-Compulsive Disorder; Phobic Disorders; Psychopharmacology; Trichotillomania

近期论文

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Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome. Xu, M., Kobets, A., Du, J.C., Lennington, J., Li, L., Banasr, M., Duman, R.S., Vaccarino, F.M., DiLeone, R.J., and Pittenger, C. (2015). Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome. Proceedings of the National Academy of Sciences, USA, 112:893-8. Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice. Calstellan Baldan, L., Williams, K.A., Gallezot, J.-D., Pogorelov, V., Rapanelli, M., Crowley, M., Anderson, G.M., Loring, E., Gorczyca, R., Billingslea, E., Wasylink, s., Panza, K.E., Ercan-Sencicek, A.G., Krusong, K., Leventhal, B.L., Ohtsu, H., Bloch, M. H., Hughes, Z. A., Krystal, J. H., Mayes, L., de Araujo, I., Ding, Y. S., State, M. W., & Pittenger, C. Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice. Neuron, 81:77-90. Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder. Anticevic, A., Hu, S., Zhang, S., Savic, A., Billingslea, E., Wasylink, S., Repovs, G., Cole, M.W., Bednarski, S., Krystal, J.H., Bloch, M.H., Li, C.S., and Pittenger, C. (2014). Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder. Biological Psychiatry, 75:595-605. Effects of ketamine in treatment-refractory obsessive-compulsive disorder. Bloch, M.H., Wasylink, S., Landeros-Weisenberger, A., Panza, K.E., Billingslea, E., Leckman, J.F., Krystal, J.H., Bhagwagar, Z., Sanacora, G., and Pittenger C. (2012).Effects of ketamine in treatment-refractory obsessive-compulsive disorder. Biol Psychiatry. 2012 Dec 1;72(11):964-70 Glutamate abnormalities in obsessive-compulsive disorder: neurobiology, pathophysiology, and treatment. Pittenger, C., Bloch, M.H., and Williams, K. (2011). Glutamate abnormalities in obsessive-compulsive disorder: neurobiology, pathophysiology, and treatment. Pharmacology and Therapeutics 132:314-32. A double dissociation revealing bidirectional competition between striatum and hippocampus during learning. Lee, A.S., Duman, R.S., and Pittenger, C. (2008). A double dissociation revealing bidirectional competition between striatum and hippocampus during learning. Proceedings of the National Academy of Sciences, USA, 105:17163-8. Keistler CR, Hammarlund E, Barker JM, Bond CW, DiLeone RJ, Pittenger C, Taylor JR: Regulation of Alcohol Extinction and Cue-Induced Reinstatement by Specific Projections among Medial Prefrontal Cortex, Nucleus Accumbens, and Basolateral Amygdala. J Neurosci. 2017 Apr 26; 2017 Mar 23. PMID: 28336571 Esterlis I, DellaGioia N, Pietrzak RH, Matuskey D, Nabulsi N, Abdallah CG, Yang J, Pittenger C, Sanacora G, Krystal JH, Parsey RV, Carson RE, DeLorenzo C: Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression. Mol Psychiatry. 2017 Apr 11; 2017 Apr 11. PMID: 28397841 Adams TG, Bloch MH, Pittenger C: Intranasal Ketamine and Cognitive-Behavioral Therapy for Treatment-Refractory Obsessive-Compulsive Disorder. J Clin Psychopharmacol. 2017 Apr. PMID: 28121735 Gruner P, Pittenger C: Cognitive inflexibility in Obsessive-Compulsive Disorder. Neuroscience. 2017 Mar 14; 2016 Aug 1. PMID: 27491478 Bortolato M, Pittenger C: Modeling tics in rodents: Conceptual challenges and paths forward. J Neurosci Methods. 2017 Feb 22; 2017 Feb 22. PMID: 28237575 Rapanelli M, Frick LR, Xu M, Groman SM, Jindachomthong K, Tamamaki N, Tanahira C, Taylor JR, Pittenger C: Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice. Biol Psychiatry. 2017 Feb 10; 2017 Feb 10. PMID: 28347488 Rapanelli M, Frick L, Pogorelov V, Ohtsu H, Bito H, Pittenger C: Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders. Transl Psychiatry. 2017 Jan 24; 2017 Jan 24. PMID: 28117842 Boedhoe PS, Schmaal L, Abe Y, Ameis SH, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Cheng Y, Cho KI, Dallaspezia S, Denys D, Fitzgerald KD, Fouche JP, Giménez M, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Nakamae T, Nakao T, Narayanaswamy JC, Piras F, Piras F, Pittenger C, Reddy YC, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, Venkatasubramanian G, Walitza S, Wang Z, van Wingen GA, Xu J, Xu X, Yun JY, Zhao Q, ENIGMA OCD Working Group., Thompson PM, Stein DJ, van den Heuvel OA: Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis. Am J Psychiatry. 2017 Jan 1; 2016 Sep 9. PMID: 27609241 Pittenger C: Histidine Decarboxylase Knockout Mice as a Model of the Pathophysiology of Tourette Syndrome and Related Conditions. Handb Exp Pharmacol. 2017. PMID: 28233179 Xu J, Hartley BJ, Kurup P, Phillips A, Topol A, Xu M, Ononenyi C, Foscue E, Ho SM, Baguley TD, Carty N, Barros CS, Müller U, Gupta S, Gochman P, Rapoport J, Ellman JA, Pittenger C, Aronow B, Nairn AC, Nestor MW, Lombroso PJ, Brennand KJ: Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models. Mol Psychiatry. 2016 Oct 18; 2016 Oct 18. PMID: 27752082 Frick L, Rapanelli M, Abbasi E, Ohtsu H, Pittenger C: Histamine regulation of microglia: Gene-environment interaction in the regulation of central nervous system inflammation. Brain Behav Immun. 2016 Oct; 2016 Jul 2. PMID: 27381299 Rapanelli M, Frick LR, Horn KD, Schwarcz RC, Pogorelov V, Nairn AC, Pittenger C: The Histamine H3 Receptor Differentially Modulates Mitogen-activated Protein Kinase (MAPK) and Akt Signaling in Striatonigral and Striatopallidal Neurons. J Biol Chem. 2016 Sep 30; 2016 Aug 10. PMID: 27510032 Rapanelli M, Pittenger C: Histamine and histamine receptors in Tourette syndrome and other neuropsychiatric conditions. Neuropharmacology. 2016 Jul; 2015 Aug 14. PMID: 26282120 Xu M, Li L, Pittenger C: Ablation of fast-spiking interneurons in the dorsal striatum, recapitulating abnormalities seen post-mortem in Tourette syndrome, produces anxiety and elevated grooming. Neuroscience. 2016 Jun 2; 2016 Mar 8. PMID: 26968763