Picciotto, Marina - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Picciotto joined the Yale faculty in 1995, after completing a postdoctoral fellowship with Jean-Pierre Changeux in the Laboratory of Molecular Neuroscience at the Institut Pasteur in Paris. She earned a Ph.D. in Molecular Neurobiology at The Rockefeller University in New York City in 1992, where she worked in the Laboratory of Molecular and Cellular Neuroscience under Paul Greengard. She received a B.S. degree in biological sciences from Stanford University, Stanford, California, in 1985. Dr. Picciotto is currently Editor-in-Chief of The Journal of Neuroscience. She served on the Scientific Council of the National Institute on Drug Abuse from 2010-2014, was Treasurer of the Society for Neuroscience from 2014-2015, and has been a Handling Editor of the Journal of Nicotine and Tobacco Research. the Journal of Neurochemistry and Neuroscience Letters. She is currently a member of the MNPS NIH Study Section and is a past member of the Neurobiology of Motivated Behavior. In 2000 she was awarded the Presidential Early Career Award in Science and Engineering by President Clinton and in 2007, she was honored with the Jacob P. Waletzky Memorial Award for Innovative Research in Drug Addiction and Alcoholism by the Society for Neuroscience. She was elected to the Institute of Medicine and the Connecticut Academy of Science and Engineering in 2012 and as a fellow of the American Association for the Advancement of Science in 2014. PhD Rockefeller University (1992) BS Stanford University (1985) BSc (Hon) Hunter College High School, (Ignore degree - HS!) (1981)

研究领域

Behavior and Behavior Mechanisms; Mental Disorders; Child Psychiatry; Nervous System Diseases; Neurobiology; Neurosciences; Nicotine; Pharmacology

近期论文

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An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior Jung, Y.-W., Hsieh, L.S., Lee, A.M., Zhou, Z., Coman, D., Heath, C.J., Hyder, F., Mineur, Y.S., Yuan, Q., Goldman, D., Bordey, A. and Picciotto, M.R. (2016) Nature Neuroscience, 19(7):905-14 Evaluation of the nicotinic acetylcholine receptor-associated proteome at baseline and following nicotine exposure in human and mouse cortext McClure-Begley, T.D., Esterlis, I., Stone, K.L., Lam, T.T., Grady, S.R., Colangelo, C.M., Lindstrom, J.M., Marks, M.J., Picciotto, M.R. (2016) eNeuro DOI: 10.1523/ENEURO.0166-16.2016 Multiple nicotinic acetylcholine receptor subtypes in the mouse amygdala regulate affective behaviors and response to social stress Mineur, Y.S., Fote, G.M., Blakeman, S., Cahuzac, E.L.M., Newbold, S.A. and Picciotto, M.R. (2016) Neuropsychopharmacology, 41(6):1579-87 Acetylcholine acts through nicotinic receptors to enhance the firing rate of a subset of hypocretin neurons in the mouse hypothalamus through distinct presynaptic and postsynaptic mechanisms Zhou, WL, Gao, X.-B. and Picciotto, M.R. (2015) eNeuro, DOI: 10.1523/ENEURO.0052-14.2015 GABAergic and glutamatergic efferents of the mouse ventral tegmental area. Taylor, S.R., Badurek, S., Dileone, R.J., Nashmi, R., Minichiello, L. and Picciotto, M.R. (2014) J Comp Neurol, 522(14):3308-34. PMC4107038 Verplaetse TL, Weinberger AH, Oberleitner LM, Smith KM, Pittman BP, Shi JM, Tetrault JM, Lavery ME, Picciotto MR, McKee SA: Effect of doxazosin on stress reactivity and the ability to resist smoking. J Psychopharmacol. 2017 Apr 1; 2017 Apr 1. PMID: 28440105 Mineur YS, Mose TN, Blakeman S, Picciotto MR: Hippocampal α7 nicotinic ACh receptors contribute to modulation of depression-like behaviour in C57BL/6J mice. Br J Pharmacol. 2017 Mar 6; 2017 Mar 6. PMID: 28264149 Roberts W, Verplaetse TL, Moore K, Oberleitner L, Picciotto MR, McKee SA: Effects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms. J Psychopharmacol. 2017 Mar 1; 2017 Mar 1. PMID: 28351203 Fan L, Balakrishna S, Jabba SV, Bonner PE, Taylor SR, Picciotto MR, Jordt SE: Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism. Tob Control. 2016 Nov; 2016 Oct 3. PMID: 27698211 Park J, Chávez AE, Mineur YS, Morimoto-Tomita M, Lutzu S, Kim KS, Picciotto MR, Castillo PE, Tomita S: CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory. Neuron. 2016 Oct 5; 2016 Sep 22. PMID: 27667007 Esterlis I, Hillmer AT, Bois F, Pittman B, McGovern E, O'Malley SS, Picciotto MR, Yang BZ, Gelernter J, Cosgrove KP: CHRNA4 and ANKK1 Polymorphisms Influence Smoking-Induced Nicotinic Acetylcholine Receptor Upregulation. Nicotine Tob Res. 2016 Sep; 2016 Mar 31. PMID: 27611310 McClure-Begley TD, Esterlis I, Stone KL, Lam TT, Grady SR, Colangelo CM, Lindstrom JM, Marks MJ, Picciotto MR: Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex. eNeuro. 2016 Jul-Aug; 2016 Aug 16. PMID: 27559543 Jung Y, Hsieh LS, Lee AM, Zhou Z, Coman D, Heath CJ, Hyder F, Mineur YS, Yuan Q, Goldman D, Bordey A, Picciotto MR: An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior. Nat Neurosci. 2016 Jul; 2016 May 30. PMID: 27239938 Lewis AS, Oberleitner LM, Morgan PT, Picciotto MR, McKee SA: Association of Cigarette Smoking With Interpersonal and Self-Directed Violence in a Large Community-Based Sample. Nicotine Tob Res. 2016 Jun; 2015 Dec 30. PMID: 26718905 Mineur YS, Fote GM, Blakeman S, Cahuzac EL, Newbold SA, Picciotto MR: Multiple Nicotinic Acetylcholine Receptor Subtypes in the Mouse Amygdala Regulate Affective Behaviors and Response to Social Stress. Neuropsychopharmacology. 2016 May; 2015 Oct 16. PMID: 26471256 Engmann O, Giralt A, Gervasi N, Marion-Poll L, Gasmi L, Filhol O, Picciotto MR, Gilligan D, Greengard P, Nairn AC, Hervé D, Girault JA: DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons. Nat Commun. 2015 Dec 7; 2015 Dec 7. PMID: 26639316 Lewis AS, Mineur YS, Smith PH, Cahuzac EL, Picciotto MR: Modulation of aggressive behavior in mice by nicotinic receptor subtypes. Biochem Pharmacol. 2015 Oct 15; 2015 Jul 23. PMID: 26212554 Mineur YS, Bentham MP, Zhou WL, Plantenga ME, McKee SA, Picciotto MR: Antidepressant-like effects of guanfacine and sex-specific differences in effects on c-fos immunoreactivity and paired-pulse ratio in male and female mice. Psychopharmacology (Berl). 2015 Oct; 2015 Jul 7. PMID: 26146014 Van Schalkwyk GI, Lewis AS, Qayyum Z, Koslosky K, Picciotto MR, Volkmar FR: Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder. J Autism Dev Disord. 2015 Sep. PMID: 25982311