O'Hern, Corey - Yale University - Biological & Biomedical Sciences

个人简介

Prof. O'Hern is an Associate Professor of Mechanical Engineering & Materials Science and Physics, co-founder of the Integrated Graduate Program in Physical and Engineering Biology, and Director of Undergraduate Programs for the Raymond and Beverly Sackler Institute for Biological, Physical, and Engineering Sciences. His research employs theoretical and computational methods (e.g. all-atom and coarse-grained molecular dynamics simulations) to tackle a broad range of fundamental questions in soft matter and biological physics. Current projects include the dynamics of protein folding, unfolding, and aggregation, the binding and self-assembly of proteins, and the structural and mechanical properties of cells and tissues in the context of collective cell motion and wound healing. PhD University of Pennsylvania, Physics (1999) BS Duke University, Physics (1994) Postdoctoral Research Associate University of California, Los Angeles Postdoctoral Research Associate University of Chicago

研究领域

Protein Conformation; Thermodynamics; Protein Folding; Cell Shape

近期论文

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G. Lois, J. Blawzdziewicz, and C. S. O'Hern, "Reliable Protein Folding on Complex Energy Landscapes: The Free Energy Reaction Path", Biophys. J. 95 (2008) 2692. A. L. Cortajarena, G. Lois, E. Sherman, C. S. O'Hern, L. Regan, and G. Haran, "Non-random-coil behavior as a consequence of extensive PPII structure in the denatured state", J. Mol. Biol. 382 (2008) 203. G. Lois, J. Blawzdziewicz, and C. S. O'Hern, "Percolation Model for Slow Dynamics in Glass-Forming Materials", Phys. Rev. Lett. 102 (2009) 015702. M. Mailman, C. F. Schreck, B. Chakraborty, and C. S. O'Hern, "Jamming in Systems Composed of Frictionless Ellipse-Shaped Particles", Phys. Rev. Lett. 102 (2009) 255501 G. Lois, J. Blawzdziewicz, and C. S. O'Hern, "Protein folding on rugged energy landscapes: Conformational diffusion on fractal networks", Phys. Rev. E 81 (2010) 051907. R. Hoy and C. S. O'Hern, "Minimal energy packings and collapse of sticky tangent hard-sphere polymers," Phys. Rev. Lett. 105 (2010) 068001. Fan M, Wang M, Zhang K, Liu Y, Schroers J, Shattuck MD, O'Hern CS: Effects of cooling rate on particle rearrangement statistics: Rapidly cooled glasses are more ductile and less reversible. Phys Rev E. 2017 Feb; 2017 Feb 28. PMID: 28297989 Noble DB, Mochrie SG, O'Hern CS, Pollard TD, Regan L: Promoting convergence: The integrated graduate program in physical and engineering biology at Yale University, a new model for graduate education. Biochem Mol Biol Educ. 2016 Nov 12; 2016 Jun 13. PMID: 27292366 Wang K, Langevin S, O'Hern CS, Shattuck MD, Ogle S, Forero A, Morrison J, Slayden R, Katze MG, Kirby M: Anomaly Detection in Host Signaling Pathways for the Early Prognosis of Acute Infection. PLoS One. 2016; 2016 Aug 17. PMID: 27532264 Virrueta A, O'Hern CS, Regan L: Understanding the physical basis for the side-chain conformational preferences of methionine. Proteins. 2016 Jul; 2016 Apr 6. PMID: 26917446 Gaines JC, Smith WW, Regan L, O'Hern CS: Random close packing in protein cores. Phys Rev E. 2016 Mar; 2016 Mar 28. PMID: 27078398 Bertrand T, Behringer RP, Chakraborty B, O'Hern CS, Shattuck MD: Protocol dependence of the jamming transition. Phys Rev E. 2016 Jan; 2016 Jan 11. PMID: 26871137 Rokhlenko Y, Gopinadhan M, Osuji CO, Zhang K, O'Hern CS, Larson SR, Gopalan P, Majewski PW, Yager KG: Magnetic Alignment of Block Copolymer Microdomains by Intrinsic Chain Anisotropy. Phys Rev Lett. 2015 Dec 18; 2015 Dec 18. PMID: 26722950 Zhang K, Fan M, Liu Y, Schroers J, Shattuck MD, O'Hern CS: Beyond packing of hard spheres: The effects of core softness, non-additivity, intermediate-range repulsion, and many-body interactions on the glass-forming ability of bulk metallic glasses. J Chem Phys. 2015 Nov 14. PMID: 26567672 Clark AH, Shattuck MD, Ouellette NT, O'Hern CS: Onset and cessation of motion in hydrodynamically sheared granular beds. Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Oct; 2015 Oct 16. PMID: 26565230 Mai M, Wang K, Huber G, Kirby M, Shattuck MD, O'Hern CS: Outcome Prediction in Mathematical Models of Immune Response to Infection. PLoS One. 2015; 2015 Aug 19. PMID: 26287609 Zhang K, Dice B, Liu Y, Schroers J, Shattuck MD, O'Hern CS: On the origin of multi-component bulk metallic glasses: Atomic size mismatches and de-mixing. J Chem Phys. 2015 Aug 7. PMID: 26254655 Caballero D, Smith WW, O'Hern CS, Regan L: Equilibrium transitions between side-chain conformations in leucine and isoleucine. Proteins. 2015 Aug. PMID: 26018846 Regan L, Caballero D, Hinrichsen MR, Virrueta A, Williams DM, O'Hern CS: Protein design: Past, present, and future. Biopolymers. 2015 Jul. PMID: 25784145 Zhang K, Liu Y, Schroers J, Shattuck MD, O'Hern CS: The glass-forming ability of model metal-metalloid alloys. J Chem Phys. 2015 Mar 14. PMID: 25770548 Wang M, Zhang K, Li Z, Liu Y, Schroers J, Shattuck MD, O'Hern CS: Asymmetric crystallization during cooling and heating in model glass-forming systems. Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Mar; 2015 Mar 17. PMID: 25871112 Shao Z, Singer JP, Liu Y, Liu Z, Li H, Gopinadhan M, O'Hern CS, Schroers J, Osuji CO: Shear-accelerated crystallization in a supercooled atomic liquid. Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Feb; 2015 Feb 18. PMID: 25768445 Smith WW, Ho PY, O'Hern CS: Calibrated Langevin-dynamics simulations of intrinsically disordered proteins. Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Oct; 2014 Oct 13. PMID: 25375525 Zhou AQ, O'Hern CS, Regan L: Predicting the side-chain dihedral angle distributions of nonpolar, aromatic, and polar amino acids using hard sphere models. Proteins. 2014 Oct; 2014 Aug 11. PMID: 24912976 Shen T, Papanikolaou S, O'Hern CS, Shattuck MD: Statistics of frictional families. Phys Rev Lett. 2014 Sep 19; 2014 Sep 15. PMID: 25279647