Noonan, James - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Noonan received his undergraduate degree in Biology and English Literature (Honors) from Binghamton University in upstate New York. He carried out his graduate work with Dr. Richard Myers in the Department of Genetics, Stanford University, and received his Ph.D. in 2004. He did his postdoctoral work in Dr. Edward Rubin's lab at the Lawrence Berkeley National Laboratory and the U.S. Department of Energy Joint Genome Institute. Dr. Noonan joined the Yale Genetics faculty in September 2007. PhD Stanford University (2004) BS State University of New York at Binghamton (1997) Postdoctoral Fellow Lawrence Berkeley National Laboratory

研究领域

Biological Evolution; Genetics; Neurosciences; Genomics; Synthetic Biology

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Origin and evolution of developmental enhancers in the mammalian neocortex. Emera D, Yin J, Reilly SK, Gockley J, Noonan JP. (2016). Origin and evolution of developmental enhancers in the mammalian neocortex. Proc. Natl. Acad. Sci. USA, epub April 25. Evolutionary changes in promoter and enhancer activity during human corticogenesis. Reilly SK, Yin J, Ayoub AE, Emera D, Leng J, Cotney J, Sarro R, Rakic P, Noonan JP. (2015). Evolutionary changes in promoter and enhancer activity during human corticogenesis. Science 347:1155-9. The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment. Cotney J, Muhle RA, Sanders SJ, Liu L, Willsey AJ, Niu W, Liu W, Klei L, Lei J, Yin J, Reilly SK, Tebbenkamp AT, Bichsel C, Pletikos M, Sestan N, Roeder K, State MW, Devlin B, Noonan JP. (2015). The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment. Nat. Commun. 6:6404. The evolution of lineage-specific regulatory activities in the human embryonic limb. Cotney J, Leng J, Yin J, Reilly SK, DeMare LE, Emera D, Ayoub AE, Rakic P, Noonan JP. (2013). The evolution of lineage-specific regulatory activities in the human embryonic limb. Cell 154:185-196. The genomic landscape of cohesin-associated chromatin interactions. DeMare LE, Leng J, Cotney J, Reilly SK, Yin J, Sarro R, Noonan JP. (2013). The genomic landscape of cohesin-associated chromatin interactions. Genome Res. 23:1224-34. Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb. Cotney J, Leng J, Oh S, DeMare LE, Reilly SK, Gerstein MB, Noonan JP. (2012). Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb. Genome Res. 22:1069-80. Transcriptional programs in transient embryonic zones of the cerebral cortex defined by high-resolution mRNA sequencing. Ayoub AE, Oh S, Xie Y, Leng J, Cotney J, Dominguez MH, Noonan JP, Rakic P. (2011). Transcriptional programs in transient embryonic zones of the cerebral cortex defined by high-resolution mRNA sequencing. Proc. Natl. Acad. Sci. USA 108:14950-55. Genomics of long-range regulatory elements. Noonan JP, McCallion AS. (2010). Genomics of long-range regulatory elements. Annu. Rev. Genomics. Hum. Genet. 11:1-23. Human-specific gain of function in a developmental enhancer. Prabhakar S, Visel A, Akiyama JA, Shoukry M, Lewis KD, Holt A, Plajzer-Frick I, Morrison H, Fitzpatrick DR, Afzal V, Pennacchio LA, Rubin EM, Noonan JP. (2008). Human-specific gain of function in a developmental enhancer. Science 321:1346-50. Accelerated evolution of conserved noncoding sequences in humans. Prabhakar S*, Noonan JP*, Pääbo S, Rubin EM. (2006). Accelerated evolution of conserved noncoding sequences in humans. Science 314: 786 *Equal contribution