Nguyen, Don - Yale University - Biological & Biomedical Sciences

个人简介

B.S., Microbiology and Immunology, McGill University, Montreal, Quebec, Canada. 1998. Ph.D., Microbiology and Immunology, University of Rochester, Rochester, NY. 2004 Post-doctoral fellow, Cancer Biology and Genetics, Memorial Sloan-Kettering Institute, New York, NY. 2004-9. PhD University of Rochester (2004) BS McGill University (1998) Post-doctoral Fellowship Memorial Sloan-Kettering Institute

研究领域

Inflammation; Lung Neoplasms; Neoplasm Metastasis; Pathology; Genomics; Neoplasm Micrometastasis

近期论文

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Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis. Cheung, W.K.C., Zhao, M., Liu, Z., Stevens, L.E., Cao, P.D., Fang, J.E., Westbrook, T.F., and Nguyen, D.X. (2013). Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis. Cancer Cell, 23 (6): 725-738. Featured article. Tracing the origins of metastasis. Nguyen DX. (2011). Tracing the origins of metastasis. J Pathol. 223(2): 196-205. WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Nguyen, D.X., Chiang, A.C., Zhang, H.F.X., Kim, J.Y., Kris, M.G., Ladanyi, M., Gerald, W.L., and Massague, J. WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell, 138(1): 51-62 (2009). Tumor self-seeding by circulating cancer cells. Kim, M-Y., Oskarsson, T., Acharyya, S., Nguyen, D.X., Zhang, X-F., Norton, L., and Massague, J. Tumor self-seeding by circulating cancer cells. Cell, 139 (7): 1315-1326 (2009). Genes that mediate metastasis through the blood-brain barrier. Bos, P.D., Zhang, H.F.X., Nadal, C., Shu. W., Gomis. R.R., Nguyen, D.X., Minn, A.J., Van de Vijver, M., Gerald, W.L., Foekens, J.A., and Massague, J. Genes that mediate metastasis through the blood-brain barrier. Nature, 459: 1005-9 (2009). Mediators of vascular remodeling co-opted for sequential steps in lung metastasis. 4. Gupta, G.P.*, Nguyen, D.X.*, Chiang, A.C., Bos, P.D., Kim, J.Y., Nadal, C., Shu, W., Gomis, R.R., Todorova-Manova, K., and Massagué, J. (2007). Mediators of vascular remodeling co-opted for sequential steps in lung metastasis. Nature, 446: 765–770. *Authors contributed equally. Stevens LE, Cheung WKC, Adua SJ, Arnal-Estapé A, Zhao M, Liu Z, Brewer K, Herbst RS, Nguyen DX: Extracellular Matrix Receptor Expression in Subtypes of Lung Adenocarcinoma Potentiates Outgrowth of Micrometastases. Cancer Res. 2017 Apr 15; 2017 Feb 14. PMID: 28196904 Arnal-Estapé A, Nguyen DX: Sweets for a bitter end: lung cancer cell-surface protein glycosylation mediates metastatic colonization. Cancer Discov. 2015 Feb. PMID: 25656895 Haskins JW, Nguyen DX, Stern DF: Neuregulin 1-activated ERBB4 interacts with YAP to induce Hippo pathway target genes and promote cell migration. Sci Signal. 2014 Dec 9; 2014 Dec 9. PMID: 25492965 Karlin KL, Mondal G, Hartman JK, Tyagi S, Kurley SJ, Bland CS, Hsu TY, Renwick A, Fang JE, Migliaccio I, Callaway C, Nair A, Dominguez-Vidana R, Nguyen DX, Osborne CK, Schiff R, Yu-Lee LY, Jung SY, Edwards DP, Hilsenbeck SG, Rosen JM, Zhang XH, Shaw CA, Couch FJ, Westbrook TF: The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor. Cell Rep. 2014 Nov 20; 2014 Nov 6. PMID: 25453754 Zito G, Saotome I, Liu Z, Ferro EG, Sun TY, Nguyen DX, Bilguvar K, Ko CJ, Greco V: Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk. Nat Commun. 2014 Mar 26; 2014 Mar 26. PMID: 24667544 Cao J, Liu Z, Cheung WK, Zhao M, Chen SY, Chan SW, Booth CJ, Nguyen DX, Yan Q: Histone demethylase RBP2 is critical for breast cancer progression and metastasis. Cell Rep. 2014 Mar 13; 2014 Feb 27. PMID: 24582965 Breindel JL, Haskins JW, Cowell EP, Zhao M, Nguyen DX, Stern DF: EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res. 2013 Aug 15; 2013 Jun 21. PMID: 23794705 Cheung WK, Zhao M, Liu Z, Stevens LE, Cao PD, Fang JE, Westbrook TF, Nguyen DX: Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis. Cancer Cell. 2013 Jun 10; 2013 May 23. PMID: 23707782 Cao PD, Cheung WK, Nguyen DX: Cell lineage specification in tumor progression and metastasis. Discov Med. 2011 Oct. PMID: 22031670 Nguyen DX: Tracing the origins of metastasis. J Pathol. 2011 Jan; 2010 Oct 29. PMID: 21125675