Neugebauer, Karla M - Yale University - Biological & Biomedical Sciences

个人简介

2001 – 2013 Research Group Leader, Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany 1999-2001 Assistant Professor, Department of Neurology, University of Washington Medical School, Seattle, WA 1998-1999 Staff Scientist at Fred Hutchinson Cancer Research Center, Seattle WA 1996-1997 Postdoc at EMBL in Heidelberg Germany 1991-1996 Postdoc at Fred Hutchinson Cancer Research Center, Seattle WA PhD University of California-San Francisco (1990) BS Cornell University (1984)

研究领域

Biochemistry; Biophysics; Cell Nucleus; Cell Biology; Molecular Biology; Zebrafish; Genomics; Nuclear Cap-Binding Protein Complex; Interstitial Cells of Cajal

近期论文

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Counting on Co-transcriptional Splicing. M. Brugiolo, L. Herzel and K.M. Neugebauer. 2013. Counting on Co-transcriptional Splicing. F1000Prime Reports 5:9-15. How cells get the message: dynamic assembly and function of mRNA-protein complexes Müller-McNicoll, M. and K.M. Neugebauer. 2013. How cells get the message: dynamic assembly and function of mRNA-protein complexes. Nature Reviews Genetics 14:275-87. First exon length controls active chromatin signatures and transcription. Bieberstein, N., F. Carrillo Oesterreich, K. Straube and K.M. Neugebauer. 2012. First exon length controls active chromatin signatures and transcription. Cell Reports 2:62-68. The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes. Änkö, M-L., M. Müller-McNicoll, H. Brandl, T. Curk, C. Gorup, I. Henry, J. Ule and K.M. Neugebauer. 2012. The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes. Genome Biology 13: R17. Global analysis of nascent RNA reveals transcriptional pausing in terminal exons. Carrillo Oesterreich, F., S. Preibisch, and K.M. Neugebauer. 2010. Global analysis of nascent RNA reveals transcriptional pausing in terminal exons. Molecular Cell 40: 571-581. Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis. Strzelecka, M, S. Trowitzsch, G. Weber, R. Lührmann, A.C. Oates and K.M. Neugebauer. 2010. Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis. Nature Structural and Molecular Biology 17: 403–409. Neugebauer KM: Special focus on the Cajal Body. RNA Biol. 2017 May 9; 2017 May 9. PMID: 28486008 Despic V, Dejung M, Gu M, Krishnan J, Zhang J, Herzel L, Straube K, Gerstein MB, Butter F, Neugebauer KM: Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Genome Res. 2017 Apr 5; 2017 Apr 5. PMID: 28381614 Alpert T, Herzel L, Neugebauer KM: Perfect timing: splicing and transcription rates in living cells. Wiley Interdiscip Rev RNA. 2017 Mar; 2016 Nov 21. PMID: 27873472 Heyn P, Neugebauer KM: Purification of Zygotically Transcribed RNA through Metabolic Labeling of Early Zebrafish Embryos. Methods Mol Biol. 2017. PMID: 28456961 Heyn P, Salmonowicz H, Rodenfels J, Neugebauer KM: Activation of transcription enforces the formation of distinct nuclear bodies in zebrafish embryos. RNA Biol. 2016 Nov 18; 2016 Nov 18. PMID: 27858508 Courchaine EM, Lu A, Neugebauer KM: Droplet organelles? EMBO J. 2016 Aug 1; 2016 Jun 29. PMID: 27357569 Carrillo Oesterreich F, Herzel L, Straube K, Hujer K, Howard J, Neugebauer KM: Splicing of Nascent RNA Coincides with Intron Exit from RNA Polymerase II. Cell. 2016 Apr 7; 2016 Mar 24. PMID: 27020755 Müller-McNicoll M, Botti V, de Jesus Domingues AM, Brandl H, Schwich OD, Steiner MC, Curk T, Poser I, Zarnack K, Neugebauer KM: SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export. Genes Dev. 2016 Mar 1. PMID: 26944680 Herzel L, Neugebauer KM: Quantification of co-transcriptional splicing from RNA-Seq data. Methods. 2015 Sep 1; 2015 Apr 27. PMID: 25929182 Courchaine E, Neugebauer KM: Paraspeckles: paragons of functional aggregation. J Cell Biol. 2015 Aug 17. PMID: 26283795 Neugebauer KM: RNA: master or servant? RNA. 2015 Apr. PMID: 25780198 Machyna M, Neugebauer KM, Staněk D: Coilin: The first 25 years. RNA Biol. 2015. PMID: 25970135 Machyna M, Kehr S, Straube K, Kappei D, Buchholz F, Butter F, Ule J, Hertel J, Stadler PF, Neugebauer KM: The coilin interactome identifies hundreds of small noncoding RNAs that traffic through Cajal bodies. Mol Cell. 2014 Nov 6; 2014 Nov 6. PMID: 25514182