Nathanson, Michael Harris - Yale University - Biological & Biomedical Sciences

个人简介

MD Case Western Reserve Univ (1985) PhD Case Western Reserve Univ (1983) MS Massachusetts Institute of Technology (1977) BS University of California, Berkeley (1976) Resident Columbia-Presbyterian Medical Center Postdoctoral Fellow Yale University Board Certification AB of Internal Medicine, Internal Medicine (1988) Board Certification AB of Internal Medicine, Gastroenterology (1991, recertified: 2011)

研究领域

Cell Nucleus; Cell Biology; Digestive System Diseases; Liver; Calcium Signaling; Hepatocytes

近期论文

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Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Echevarria, W., Leite, M.F., Guerra, M.T., Zipfel, W.R., and Nathanson, M.H.: Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nature Cell Biology 5:440-446, 2003. Hormonal regulation of nuclear permeability. O’Brien, E.M., Gomes, D.A., Sehgal, S., and Nathanson, M.H.: Hormonal regulation of nuclear permeability. J. Biol. Chem. 282:4210-4217, 2007. c-Met must translocate to the nucleus to initiate Ca2+ signals. Gomes, D.A., Rodrigues, M.A., Leite, M.F., Gomez, M.V., Varnai, P., Balla, T., Bennett, A.M., and Nathanson, M.H.: c-Met must translocate to the nucleus to initiate Ca2+ signals. J. Biol. Chem. 283:4344-4351, 2008. The insulin receptor translocates to the nucleus to regulate cell proliferation in liver. Amaya, M.J., Oliveira, A.G., Guimaraes, E.S., Casteluber, M.C.F., Carvalho, S.M., Andrade, L.M., Pinto, M.C.X., Resende, R.R., Menezes, G.B., Nathanson, M.H., and Leite, M.F.: The insulin receptor translocates to the nucleus to regulate cell proliferation in liver. Hepatology 59:274-283, 2014. Apical localization of inositol 1,4,5-trisphosphate receptors is independent of extended synaptotagmins in hepatocytes. Amaya, M.J., Oliveira, A.G, Schroeder, L.K., Allgeyer, E.S., Bewersdorf, J., and Nathanson, M.H.: Apical localization of inositol 1,4,5-trisphosphate receptors is independent of extended synaptotagmins in hepatocytes. PLoS One, 1;9(12), 2014. Post-translational regulation of the type III inositol 1,4,5-trisphosphate receptor by miRNA-506. Ananthanarayanan, M., Banales, J.M., Guerra, M.T., Spirli, C., Tafur, D., Munoz-Garrido, P., Saez, E. and Nathanson, M.H.: Post-translational regulation of the type III inositol 1,4,5-trisphosphate receptor by miRNA-506. J. Biol. Chem. 290:184-196, 2015. Nuclear and cytosolic calcium are regulated independently. Leite, M.F., Thrower, E.C., Echevarria, W., Koulen, P., Hirata, Bennett, A.M., Ehrlich, B.E., and Nathanson, M.H.: Nuclear and cytosolic calcium are regulated independently. Proc. Natl. Acad. Sci. USA 100: 2975-2980, 2003. Nuclear Factor Erythroid 2-like 2 Regulates Expression of Inositol 1,4,5-trisphosphate Receptor, Type 3 and Calcium Signaling in Cholangiocytes. Weerachayaphorn, J., Amaya, M.J., Spirli, C., Chansela, P., Mitchell, K.A., Ananthanarayanan, M., and Nathanson, M.H.: Nuclear Factor Erythroid 2-like 2 Regulates Expression of Inositol 1,4,5-trisphosphate Receptor, Type 3 and Calcium Signaling in Cholangiocytes. Gastroenterology 149:211-222, 2015. Iwakiri Y, Nathanson MH: Alcohol and calcium make a potent cocktail. J Physiol. 2017 May 15; 2017 Apr 18. PMID: 28295353 Kruglov E, Ananthanarayanan M, Sousa P, Weerachayaphorn J, Guerra MT, Nathanson MH: Type 2 inositol trisphosphate receptor gene expression in hepatocytes is regulated by cyclic AMP. Biochem Biophys Res Commun. 2017 May 6; 2017 Mar 19. PMID: 28327356 Khamphaya T, Chansela P, Piyachaturawat P, Suksamrarn A, Nathanson MH, Weerachayaphorn J: Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats. Eur J Pharmacol. 2016 Oct 15; 2016 Jul 27. PMID: 27475677 Nathanson MH, Terrault N: Hepatitis B surface antigen loss: Not all that we hoped it would be. Hepatology. 2016 Aug; 2016 Jun 16. PMID: 27178231 Omary MB, Cohen DE, El-Omar E, Jalan R, Low M, Nathanson M, Peek R, Turner J: Not All Mice Are the Same: Standardization of Animal Research Data Presentation. Gut. 2016 Jun. PMID: 27197119 Weerachayaphorn J, Amaya MJ, Spirli C, Chansela P, Mitchell-Richards KA, Ananthanarayanan M, Nathanson MH: Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes. Gastroenterology. 2015 Jul; 2015 Mar 18. PMID: 25796361 Guerra MT, Nathanson MH: Calcium signaling and secretion in cholangiocytes. Pancreatology. 2015 Jul; 2015 Jun 12. PMID: 26100660 Nathanson MH: What is Hepatology looking for? Hepatology. 2015 Apr; 2015 Mar 10. PMID: 25581014 Ananthanarayanan M, Banales JM, Guerra MT, Spirli C, Munoz-Garrido P, Mitchell-Richards K, Tafur D, Saez E, Nathanson MH: Post-translational regulation of the type III inositol 1,4,5-trisphosphate receptor by miRNA-506. J Biol Chem. 2015 Jan 2; 2014 Nov 5. PMID: 25378392