Nairn, Angus Clark - Yale University - Biological & Biomedical Sciences

个人简介

Angus Nairn did his undergraduate training in biochemistry at the University of Edinburgh, Scotland and his PhD in muscle biochemistry in the laboratory of Professor Sam Perry at Birmingham University, England. He then carried out postdoctoral research in molecular neuroscience with Professor Paul Greengard at Yale, and moved with Professor Greengard to Rockefeller University in 1983 as a faculty member. He moved back to Yale University in 2001, where he is currently the Charles B.G. Murphy Professor of Psychiatry. He also holds a joint appointment in the Department of Pharmacology and is co-director of the Yale/National Institute of Drug Abuse Neuroproteomics Center at the Yale School of Medicine. PhD University of Birmingham (1979) Postdoctoral Fellow Yale University

研究领域

Dopamine; Huntington Disease; Parkinson Disease; Protein Kinases; Psychiatry; Schizophrenia; Signal Transduction

近期论文

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STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson’s disease. Kurup et al. (2015) STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson’s disease. Proc. Natl. Acad. Sci. USA. 112:1202-7. Decoding neuroproteomics: integrating the genome, translatome and functional anatomy. Kitchen et al (2014) Decoding neuroproteomics: integrating the genome, translatome and functional anatomy. Nature Neuroscience. 17:1491-1499 Carlyle et al. (2014) Age-Related Loss of Phosphodiesterase 4A Puts Association Cortex at Risk for Degeneration. Proc. Natl. Acad. Sci. USA. 111:5036 41. Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCF[beta]TRCP ubiquitin E3 ligase. Wiseman et al (2013) Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCF[beta]TRCP ubiquitin E3 ligase. J. Biol. Chem. 288:17803-11 Recent advances in quantitative neuroproteomics. Craft et al (2013) Recent advances in quantitative neuroproteomics. Methods. 61(3):186-218. Beyond the dopamine receptor: regulation and roles of serine/threonine protein phosphatases. Walaas et al. (2011) Beyond the Dopamine Receptor: Regulation and Roles of Serine/Threonine Protein Phosphatases. Front Neuroanat. 5:50. Phosphorylation of RapGAP1, a striatally enriched protein, by protein kinase A controls Rap activity and dendritic spine morphology. McAvoy et al (2009) Phosphorylation of RapGAP1, a striatally enriched protein, by protein kinase A controls Rap activity and dendritic spine morphology. Proc. Natl. Acad. Sci. USA. 106:3531-3536. Stipanovich et al (2008) A phosphatase cascade by which natural rewards and drugs of abuse regulate nucleosomal response. Nature 453:879-884. Ahn et al (2007) Protein kinase A activates Protein Phosphatase 2A by phosphorylation of the B56 subunit. Proc. Natl. Acad. Sci. USA. 104:2979-84. Xu J, Kurup P, Nairn AC, Lombroso PJ: Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP61. Mol Neurobiol. 2017 May 2; 2017 May 2. PMID: 28466270 Andrade EC, Musante V, Horiuchi A, Matsuzaki H, Brody AH, Wu T, Greengard P, Taylor JR, Nairn AC: ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase). J Neurosci. 2017 Mar 8; 2017 Feb 6. PMID: 28167675 Ceglia I, Lee KW, Cahill ME, Graves SM, Dietz D, Surmeier DJ, Nestler EJ, Nairn AC, Greengard P, Kim Y: WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine. Proc Natl Acad Sci U S A. 2017 Feb 7; 2017 Jan 23. PMID: 28115704 Nishi A, Matamales M, Musante V, Valjent E, Kuroiwa M, Kitahara Y, Rebholz H, Greengard P, Girault JA, Nairn AC: Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution. J Biol Chem. 2017 Jan 27; 2016 Dec 20. PMID: 27998980 Xu J, Hartley BJ, Kurup P, Phillips A, Topol A, Xu M, Ononenyi C, Foscue E, Ho SM, Baguley TD, Carty N, Barros CS, Müller U, Gupta S, Gochman P, Rapoport J, Ellman JA, Pittenger C, Aronow B, Nairn AC, Nestor MW, Lombroso PJ, Brennand KJ: Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models. Mol Psychiatry. 2016 Oct 18; 2016 Oct 18. PMID: 27752082 Rapanelli M, Frick LR, Horn KD, Schwarcz RC, Pogorelov V, Nairn AC, Pittenger C: The Histamine H3 Receptor Differentially Modulates Mitogen-activated Protein Kinase (MAPK) and Akt Signaling in Striatonigral and Striatopallidal Neurons. J Biol Chem. 2016 Sep 30; 2016 Aug 10. PMID: 27510032 Rich MT, Abbott TB, Chung L, Gulcicek EE, Stone KL, Colangelo CM, Lam TT, Nairn AC, Taylor JR, Torregrossa MM: Phosphoproteomic Analysis Reveals a Novel Mechanism of CaMKIIα Regulation Inversely Induced by Cocaine Memory Extinction versus Reconsolidation. J Neurosci. 2016 Jul 20. PMID: 27445140 Xu J, Kurup P, Baguley TD, Foscue E, Ellman JA, Nairn AC, Lombroso PJ: Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice. Cell Mol Life Sci. 2016 Apr; 2015 Oct 8. PMID: 26450419 Xu J, Kurup P, Azkona G, Baguley TD, Saavedra A, Nairn AC, Ellman JA, Pérez-Navarro E, Lombroso PJ: Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels. J Neurochem. 2016 Jan; 2015 Sep 17. PMID: 26316048 Kamceva M, Benedict J, Nairn AC, Lombroso PJ: Role of Striatal-Enriched Tyrosine Phosphatase in Neuronal Function. Neural Plast. 2016; 2016 Apr 12. PMID: 27190655