Myung, Peggy - Yale University - Biological & Biomedical Sciences

个人简介

Peggy Myung is interested in hair follicle development and regeneration. Currently, she studies hair follicle development in mice and has a focus on how the dermal niche regulates hair follicle cell fate decisions. In particular, her work is centered on understanding the epithelial-mesenchymal interactions that regulate epithelial growth and differentiation in an effort to re-purpose these same molecular mechanisms to suppress aberrant growth in carcinogenesis. MD/PhD University of Pennsylvania (2003) Fellowship Yale University School of Medicine Residency University Hospitals Case Medical Center Residency Hospital of the University of Pennsylvania Internship Hospital of the University of Pennsylvania Board Certification AB of Dermatology, Dermatology (2012) Board Certification AB of Dermatology, Dermatopathology (2014)

研究领域

Dermatology; Epidermis; Homeostasis; Pathology; Regeneration; Stem Cells; Wound Healing; Carcinogenesis

近期论文

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Deschene E*, Myung P*, Rompolas P, Zito G, Taketo M, Saotome I, and V. Greco. 2014. ß-catenin activation regulates tissue growth via a non-cell autonomous mechanism within the hair stem cell niche. Science. 343:1353-1356. * Co-first author Epithelial Wnt ligand secretion is required for adult hair follicle regeneration. Myung, P., Takeo, M., Ito M., and R. Atit. 2013. Epithelial Wnt ligand secretion is required for adult hair follicle regeneration. J. Invest. Dermatol. 133:31-41. Dissecting the bulge in hair regeneration. Myung, P. and M. Ito. 2012. Dissecting the bulge in hair regeneration. J. Clin. Invest. 122:448-454. Coordinated activation of Wnt signaling in epithelial and melanocyte stem cells in a shared niche initiates pigmented hair follicle regeneration. Rabbani, P., Takeo, M., Chou, W., Myung, P., Bosenberg, M., Chin, L., and M. Ito. 2011. Coordinated activation of Wnt signaling in epithelial and melanocyte stem cells in a shared niche initiates pigmented hair follicle regeneration. Cell. 145:941-955.. Hardwiring stem cell communication through tissue structure. Xin T, Greco V, & Myung P. (2016). Hardwiring stem cell communication through tissue structure. Cell. 164:1212-1225. PMCID: PMC4805424 Xin T, Greco V, Myung P: Hardwiring Stem Cell Communication through Tissue Structure. Cell. 2016 Mar 10. PMID: 26967287 Neckman JP, Kim J, Mathur M, Myung P, Girardi M: Diverse cutaneous manifestations of Erdheim-Chester disease in a woman with a history of Langerhans cell histiocytosis. JAAD Case Rep. 2016 Mar; 2016 Mar 5. PMID: 27051852 Myung P, Greco V: Stem Cells Show Parental Control. Cell. 2015 Jul 30. PMID: 26232219 Mesa KR, Rompolas P, Zito G, Myung P, Sun TY, Brown S, Gonzalez DG, Blagoev KB, Haberman AM, Greco V: Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool. Nature. 2015 Jun 4; 2015 Apr 6. PMID: 25849774 Deschene ER, Myung P, Rompolas P, Zito G, Sun TY, Taketo MM, Saotome I, Greco V: β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche. Science. 2014 Mar 21. PMID: 24653033 Myung PS, Takeo M, Ito M, Atit RP: Epithelial Wnt ligand secretion is required for adult hair follicle growth and regeneration. J Invest Dermatol. 2013 Jan; 2012 Jul 19. PMID: 22810306 Myung P, Ito M: Dissecting the bulge in hair regeneration. J Clin Invest. 2012 Feb; 2012 Feb 1. PMID: 22293183 Rabbani P, Takeo M, Chou W, Myung P, Bosenberg M, Chin L, Taketo MM, Ito M: Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration. Cell. 2011 Jun 10. PMID: 21663796 Myung P, Andl T, Ito M: Defining the hair follicle stem cell (Part II). J Cutan Pathol. 2009 Oct. PMID: 19712246 Myung P, Andl T, Ito M: Defining the hair follicle stem cell (Part I). J Cutan Pathol. 2009 Sep. PMID: 19674210 Myung PS, Kundu M, Abboud SK: Eosinophilic granuloma manifesting as painless cervical lymphadenopathy in a patient positive for human immunodeficiency virus 1. Arch Otolaryngol Head Neck Surg. 2008 Feb. PMID: 18283165 Singer AL, Bunnell SC, Obstfeld AE, Jordan MS, Wu JN, Myung PS, Samelson LE, Koretzky GA: Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function. J Biol Chem. 2004 Apr 9; 2004 Jan 13. PMID: 14722089 Nichols KE, Haines K, Myung PS, Newbrough S, Myers E, Jumaa H, Shedlock DJ, Shen H, Koretzky GA: Macrophage activation and Fcgamma receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors. J Leukoc Biol. 2004 Mar; 2003 Dec 23. PMID: 14694181 Judd BA, Myung PS, Obergfell A, Myers EE, Cheng AM, Watson SP, Pear WS, Allman D, Shattil SJ, Koretzky GA: Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling. J Exp Med. 2002 Mar 18. PMID: 11901197