Morris, Evan D - Yale University - Biomedical Engineering

个人简介

Evan D. Morris, PhD has been working in the field of PET and functional imaging for 20 years. He specializes in kinetic modeling of dynamic image data. He was trained as a biomedical engineer and before that as a chemical engineer. In the past, he has taught courses at the undergraduate and graduate levels in Medical Imaging, Tracer Kinetics, Biomedical Transport, and Biomedical Ethics, among others. For more info about his past classroom teaching at Indiana University, Purdue University at Indianapolis (IUPUI), including online lectures (video and Powerpoints) for some courses, please follow the link to his IUPUI website. Morris joined the Yale PET Center as Co-Director of the Imaging Section in the fall of 2009. Dr Morris and his students have been working on kinetic models to estimate the dynamics of endogenous neurotransmitters from PET data. Their most recent publication appeared in Neuroimage in 2010. It demonstrates a novel analysis strategy for creating the first ever “movies” of dopamine action in the living brain. Altered neurotransmitter kinetics may explain the mechanism of addiction of some drugs. This work uses knowledge of numerical methods, biochemistry, image and signal processing, parameter estimation, and programming. A collection of papers to result from this project can be downloaded as a zip file here. The work was funded by the Whitaker Foundation and the National Institute on Alcohol Abuse and Alcoholism. Morris and his colleagues at Indiana University have focused much of their efforts on the use of PET to understand what makes drugs and alcohol addictive. It is the first demonstration in humans of the neurochemistry of reward prediction error. This work uses knowledge of neuropsychology, image processing, experimental study design, neurochemistry, and kinetic modeling.

研究领域

Morris is currently interested in the use of PET imaging (of people and animals) with neuroreceptor tracers to understand and improve treatments for Parkinson’s disease, alcoholism, smoking, and drug abuse. Other recent interests of Prof Morris: Small animal imaging. A recent paper details the design and validation of a stereotactic head-holder for imaging two rats in a PET scanner at the same time. The paper was published in Journal of Neuroscience Methods.

近期论文

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Cosgrove KP, Wang S, Kim SJ, McGovern E, Nabulsi N, Gao H, Labaree D, Tagare HD, Sullivan JM, Morris ED. Sex Differences in the Brain's Dopamine Signature of Cigarette Smoking. J Neurosci. 2014 Dec 10;34(50):16851-5. Kim SJ, Sullivan JM, Wang S, Cosgrove KP, Morris ED, Voxelwise lp-ntPET for detecting localized, transient dopamine release of unknown timing: Sensitivity Analysis and Application to Cigarette Smoking in the PET Scanner, Hum Brain Mapp. 2014 Sep;35(9):4876-91. Petrulli JR, Sullivan JM, Zheng MQ, Bennett DC, Charest J, Huang Y, Morris ED, Contessa JN. Quantitative analysis of [11C]-erlotinib PET demonstrates specific binding for activating mutations of the EGFR kinase domain. Neoplasia. 2013 Dec;15(12):1347-53. Sullivan JM, Kim SJ, Cosgrove KP, Morris ED. Limitations of SRTM, Logan graphical method, and equilibrium analysis for measuring transient dopamine release with [(11)C]raclopride PET. Am J Nucl Med Mol Imaging. 2013 Apr 9;3(3):247-60. Normandin MD, Schiffer WK, Morris ED. A linear model for estimation of neurotransmitter response profiles from dynamic PET data. Neuroimage. 2012 Feb 1;59(3):2689-99