Melia, Thomas - Yale University - Biological & Biomedical Sciences

个人简介

PhD Baylor College of Medicine (1999) BS Carnegie Mellon Univ (1992)

研究领域

Autophagy; Cell Biology; Lysosomes; Phagosomes; Protein Aggregates

近期论文

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Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3. Nath S, Dancourt J, Shteyn V, Puente G, Fong WM, Nag S, Bewersdorf J, Yamamoto A, Antonny B, Melia TJ. 2014. Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3. Nature Cell Biology, 16(5), p 415-424. The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Choy, A., J. Dancourt, B. Mugo, T.J. O'Connor, R.R. Isberg, T.J. Melia*, and C.R. Roy. 2012. The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science, 338(6110): p. 1072-6. SNARE proteins are required for macroautophagy. Usha Nair, Anjali Jotwani, Jiefei Geng, Noor Gammoh, Diana Richerson, Wei-Lien Yen, Janice Griffith, Shanta Nag, Ke Wang, Tyler Moss, Fulvio Reggiori, Misuzu Baba, James A. McNew, Xuejun Jiang, Thomas J. Melia*, and Daniel J. Klionsky*. 2011. SNARE proteins are required for macroautophagy. Cell. Acetylation-Dependent Clearance of Soluble Mutant Huntingtin by Autophagy Jeong H., Then F., Melia, T., Mazzulli, J.R., Cui, L., Savas, J.N., Voisine, C., Tanese N., Hart A.C., Yamamoto, A. and Krainc, D. 2009. Acetylation-Dependent Clearance of Soluble Mutant Huntingtin by Autophagy. Cell 137, 60-72. Selective activation of cognate SNAREpins by Sec1/Munc18 proteins. Shen, J., Tareste, D.C., Paumet, F., Rothman, J.E., and Melia, T.J. 2007. Selective activation of cognate SNAREpins by Sec1/Munc18 proteins. Cell, 128, 183-195. Yu S, Melia TJ: The coordination of membrane fission and fusion at the end of autophagosome maturation. Curr Opin Cell Biol. 2017 Apr 29; 2017 Apr 29. PMID: 28463755 Nguyen N, Shteyn V, Melia TJ: Sensing Membrane Curvature in Macroautophagy. J Mol Biol. 2017 Feb 17; 2017 Jan 11. PMID: 28088480 Holland P, Knævelsrud H, Søreng K, Mathai BJ, Lystad AH, Pankiv S, Bjørndal GT, Schultz SW, Lobert VH, Chan RB, Zhou B, Liestøl K, Carlsson SR, Melia TJ, Di Paolo G, Simonsen A: HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels. Nat Commun. 2016 Dec 22; 2016 Dec 22. PMID: 28004827 Horenkamp FA, Kauffman KJ, Kohler LJ, Sherwood RK, Krueger KP, Shteyn V, Roy CR, Melia TJ, Reinisch KM: The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs. Dev Cell. 2015 Sep 14; 2015 Sep 3. PMID: 26343456 Dancourt J, Melia TJ: Lipidation of the autophagy proteins LC3 and GABARAP is a membrane-curvature dependent process. Autophagy. 2014 Aug; 2014 Jun 12. PMID: 24991828 Nath S, Dancourt J, Shteyn V, Puente G, Fong WM, Nag S, Bewersdorf J, Yamamoto A, Antonny B, Melia TJ: Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3. Nat Cell Biol. 2014 May; 2014 Apr 20. PMID: 24747438 Choy A, Dancourt J, Mugo B, O'Connor TJ, Isberg RR, Melia TJ, Roy CR: The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science. 2012 Nov 23; 2012 Oct 25. PMID: 23112293 Shi L, Shen QT, Kiel A, Wang J, Wang HW, Melia TJ, Rothman JE, Pincet F: SNARE proteins: one to fuse and three to keep the nascent fusion pore open. Science. 2012 Mar 16. PMID: 22422984 Jotwani A, Richerson DN, Motta I, Julca-Zevallos O, Melia TJ: Approaches to the study of Atg8-mediated membrane dynamics in vitro. Methods Cell Biol. 2012. PMID: 22325599 Xu Y, Melia TJ, Toomre DK: Using light to see and control membrane traffic. Curr Opin Chem Biol. 2011 Dec; 2011 Nov 10. PMID: 22079055 Shi L, Kümmel D, Coleman J, Melia TJ, Giraudo CG: Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex. Mol Biol Cell. 2011 Nov; 2011 Sep 7. PMID: 21900493 Ji H, Coleman J, Yang R, Melia TJ, Rothman JE, Tareste D: Protein determinants of SNARE-mediated lipid mixing. Biophys J. 2010 Jul 21. PMID: 20643074 Giraudo CG, Garcia-Diaz A, Eng WS, Chen Y, Hendrickson WA, Melia TJ, Rothman JE: Alternative zippering as an on-off switch for SNARE-mediated fusion. Science. 2009 Jan 23. PMID: 19164750